Hyaluronic acid-based levofloxacin nanomicelles for nitric oxide-triggered drug delivery to treat bacterial infections

Lu, Chunbo; Xiao, Yao; Liu, Yinyin; Sun, Feifei; Qiu, Yuanhao; Mu, Haibo; Duan, Jinyou

doi:10.1016/j.carbpol.2019.115479

Cited by 37 publications

(25 citation statements)

References 27 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Pure CIP was initially successfully linked to HA via amide bond formation via protection of acidic group of CIP by methylation in 24 h reflux reaction, followed by the addition of HA through EDAC/NHS coupling. Pure carboxylic acid protected CIP was added in the preformed reaction mixture, and 0.1% polymeric solution of HA was prepared, and its pH was adjusted to 5 by adding 5M NaOH [ 22 ]. Furthermore, EDAC (500 mg) was added, followed by continuous stirring for 2 h to activate carboxyl groups of HA.…”

Section: Methodsmentioning

confidence: 99%

A Hyaluronic Acid Functionalized Self-Nano-Emulsifying Drug Delivery System (SNEDDS) for Enhancement in Ciprofloxacin Targeted Delivery against Intracellular Infection

et al. 2021

View full text Add to dashboard Cite

Ciprofloxacin (CIP), a potent anti-bacterial agent of the fluroquinolone family, shows poor solubility and permeability, thus leading to the development of intracellular pathogens induced multi-drug resistance and biofilms formation. To synergistically improve the biopharmaceutical parameters of CIP, a hyaluronic acid (FDA approved biocompatible polymer) functionalized self-nano emulsifying drug delivery system (HA-CIP-SNEDDS) was designed in the present study. SNEDDS formulations were tested via solubility, droplet size, zeta potential, a polydispersity index, thermodynamic stability, surface morphology, solid-state characterization, drug loading/release, cellular uptake, and biocompatibility. The final (HA-CIP-SNEDDS) formulation exhibited a mean droplet size of 50 nm with the 0.3 poly dispersity index and negative zeta potential (−11.4 mV). HA-based SNEDDS containing CIP showed an improved ability to permeate goat intestinal mucus. After 4 h, CIP-SNEDDS showed a 2-fold and HA-CIP-SNEDDS showed a 4-fold permeation enhancement as compared to the free CIP. Moreover, 80% drug release of HA-CIP-SNEDDS was demonstrated to be superior and sustained for 72 h in comparison to free CIP. However, anti-biofilm activity of HA-CIP-SNEDDS against Salmonella typhi was higher than CIP-SNEDDS and free CIP. HA-CIP-SNEDDS exhibited increased biocompatibility and improved oral pharmacokinetics as compared to free CIP. Taken together, HA-CIP-SNEDDS formulation seems to be a promising agent against Salmonella typhi with a strong targeting potential.

show abstract

Section: Methodsmentioning

confidence: 99%

A Hyaluronic Acid Functionalized Self-Nano-Emulsifying Drug Delivery System (SNEDDS) for Enhancement in Ciprofloxacin Targeted Delivery against Intracellular Infection

et al. 2021

View full text Add to dashboard Cite

show abstract

“…Carbohydrates: Mannose [57], Curdlan (a linear β-1,3 glucan) [115], Hyaluronic acid [75], Dextran [103] Mannose receptor, Dectin-1 receptor, CD44…”

Section: Bacterial Toxins Immune Cells In Presence Of Bacterial Toxinsmentioning

confidence: 99%

Application of Polymeric Nanocarriers for Enhancing the Bioavailability of Antibiotics at the Target Site and Overcoming Antimicrobial Resistance

Karakasyan

Jouenne

et al. 2021

Applied Sciences

View full text Add to dashboard Cite

Antimicrobial resistance is one of the greatest threats to global health. Although the efforts in antibiotic drug discovery continue to play a pivotal role, this solution alone probably will not be enough to ensure the required level of infection control in the future. New strategies and innovative modes of action are desperately needed to preserve the effectiveness of antimicrobials. Accordingly, antibiotic delivery based on polymeric nanoparticles is one of the possible methods that has been recently explored to improve their pharmacokinetic profile. Through optimized access of antibiotics to their sites of action, nanocarriers can unlock the full potential of the antibiotic cargoes, extend the antimicrobial spectrum, and reduce the required dose of antibiotic while preserving efficacy. Additionally, the use of an antibiotic-loaded nanocarrier is also considered a steady solution as novel molecules can be continuously developed and incorporated into the delivery platform. This review describes the present state of polymeric nanocarriers in enhancing antibiotic treatment, including improved pharmacokinetic properties and restored antibiotic efficacy against drug-resistant bacteria. Additionally, the current challenges and the future direction of this field are discussed.

show abstract

“…1) that converted into benzotriazole upon interaction with NO under extremely mild conditions to modify the overall selfassembly behavior of the polymeric nanoaggregates. Thereafter, poly(ethylene oxide)-and hyaluronic acid-based NO-targeted polymers have also been prepared (Table 1), 9,10 both relying on o-phenylenediamine groups for disassembly of nanorods, as well as cleavage of levofloxacin-conjugated hyaluronic acid for targeted delivery of rhodamine 6G and levofloxacin, respectively. These studies demonstrated the immense potential of and increasing interest in NO-responsive polymers, although they still pale very much in comparison to studies involving NO-releasing polymers, even when extended beyond the realm of drug delivery.…”

Section: Nitric Oxide (No)mentioning

confidence: 99%

The unexplored potential of gas‐responsive polymers in drug delivery: progress, challenges and outlook

Yong

Kakkar

2021

Polymer International

View full text Add to dashboard Cite

Targeted drug delivery based on polymeric nanoparticles has been a long‐standing interest in nanomedicine for its beneficial traits including controlled and localized drug release. Gas‐responsive polymers offer an advantageous platform and have been slowly gaining attention in spatially locating and displaying unique interactions of specific responsive chemical entities in polymeric chains with endogenous gaseous stimuli. In this review, we highlight recent developments in polymeric nanoformulations with stimulant chemical entities for gasotransmittors such as NO, CO, H2S, SO2, O2 and CO2 in enhancing efficacy in therapeutic interventions. We underline some challenges and limitations of exploring these systems for clinical applications, and how we can further tap into the potential of these emerging materials. © 2021 Society of Industrial Chemistry.

show abstract

Hyaluronic acid-based levofloxacin nanomicelles for nitric oxide-triggered drug delivery to treat bacterial infections

Cited by 37 publications

References 27 publications

A Hyaluronic Acid Functionalized Self-Nano-Emulsifying Drug Delivery System (SNEDDS) for Enhancement in Ciprofloxacin Targeted Delivery against Intracellular Infection

A Hyaluronic Acid Functionalized Self-Nano-Emulsifying Drug Delivery System (SNEDDS) for Enhancement in Ciprofloxacin Targeted Delivery against Intracellular Infection

Application of Polymeric Nanocarriers for Enhancing the Bioavailability of Antibiotics at the Target Site and Overcoming Antimicrobial Resistance

The unexplored potential of gas‐responsive polymers in drug delivery: progress, challenges and outlook

Contact Info

Product

Resources

About