Hyaluronic acid-functionalized halloysite nanotubes for targeted drug delivery to CD44-overexpressing cancer cells

Mo, Xiaoyun; Wu, Fengjie; Liu, Ying; Cai, Xiulan

doi:10.1016/j.mtcomm.2021.102682

Cited by 19 publications

(6 citation statements)

References 41 publications

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“…Because human cervical cancer cells (HeLa) can express CD44, 32 they can be used as proof of cancer cells. Therefore, this HeLa cell model was adopted in this experiment to assess the adhesion performance of cancer cells cultured on composite hydrogels for different time.…”

Section: Resultsmentioning

confidence: 99%

Preparation of a “Branch-Fruit” structure chitosan nanofiber physical hydrogels with high mechanical strength and pH-responsive controlled drug release properties

Wen

Zhang

et al. 2022

RSC Adv.

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Section: Resultsmentioning

confidence: 99%

Preparation of a “Branch-Fruit” structure chitosan nanofiber physical hydrogels with high mechanical strength and pH-responsive controlled drug release properties

Wen

Zhang

et al. 2022

RSC Adv.

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“…The CD44 receptor is overexpressed in gliomas, non-small-cell lung cancer, breast cancer, colon cancer and ovarian cancer cells. 141 Hyaluronic acid capped nanoparticles can bind to overexpressed CD44 receptors at the cell membranes of cancer cells and often enter cancer cells via clathrin-independent/dynamin-independent endocytosis (CLIC/GEEC). Jeannot et al compared the uptake of hyaluronan-based nanoparticles with two sizes (30 nm and 300 nm) on three lung cancer cell lines: H322, H358 and A549 cells.…”

Section: Optimal Surface Chemistry Of Nanoparticles For Selective Upt...mentioning

confidence: 99%

How can we use the endocytosis pathways to design nanoparticle drug-delivery vehicles to target cancer cells over healthy cells?

et al. 2022

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“…As evidenced by confocal microscopy, the cellular uptake was enhanced due to the tumor homing effect. Moreover, the preparation showed improved therapeutic effect due to internalization of DOX inside the cell ( Mo et al, 2021 ).…”

Section: Cd44 Engineered Nanocarriers For Cancer Therapymentioning

confidence: 99%

CD44-Targeted Nanocarrier for Cancer Therapy

et al. 2022

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Cluster of differentiation 44 (CD44) is a cell surface glycoprotein overexpressed in varieties of solid tumors including pancreatic, breast, ovary, brain, and lung cancers. It is a multi-structural glycoprotein of the cell surface which is majorly involved in cell proliferation, cell-to-cell interaction, cellular migration, inflammation, and generation of immune responses. Numerous studies focus on the development of nanocarriers for active targeting of the CD44 receptor to improve efficacy of targeting chemotherapy and achieve precise chemotherapy by defining the release, uptake, and accumulation of therapeutic agents. The CD44 receptor has a selective binding affinity towards hyaluronic and chondroitin sulfate (CS). Taking this into consideration, this review focused on the role of CD44 in cancer and its therapy using several nanocarriers such as polymeric/non-polymeric nanoparticles, dendrimer, micelles, carbon nanotubes, nanogels, nanoemulsions etc., for targeted delivery of several chemotherapeutic molecules and nucleic acid. This review also illuminates the role of hyaluronic acid (HA) in cancer therapy, interaction of HA with CD44, and various approaches to target CD44-overexpressed neoplastic cells.

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Hyaluronic acid-functionalized halloysite nanotubes for targeted drug delivery to CD44-overexpressing cancer cells

Cited by 19 publications

References 41 publications

Preparation of a “Branch-Fruit” structure chitosan nanofiber physical hydrogels with high mechanical strength and pH-responsive controlled drug release properties

Preparation of a “Branch-Fruit” structure chitosan nanofiber physical hydrogels with high mechanical strength and pH-responsive controlled drug release properties

How can we use the endocytosis pathways to design nanoparticle drug-delivery vehicles to target cancer cells over healthy cells?

CD44-Targeted Nanocarrier for Cancer Therapy

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