Hyaluronic Acid-Modified ZIF-8 Nano-Vehicle for Self-Adaption Release of Curcumin for the Treatment of Burns

Abstract

Scarring is caused by excessive medical treatment in the tissue remodeling stage; hence, the need for medication is not constant throughout the stage of burn recovery. In this study, we construct a nano self-adaption release system (Cur-ZIF8-HA) using hyaluronic acid (HA)-modified zeolite-imidazole-frame-8 (ZIF-8) as the nano-vehicle and curcumin (Cur) as the bioactive compound for the treatment of burns. The release of Cur within 48 h in the media of pH 8.5, pH 6.0, and pH 7.4 was 13.94, 54.05, and 20.17%, which could realize antibacterial functions in the inflammation stage, wound healing in the tissue proliferation/formation stage, and prevention of excessive fibroblast development and aberrant extracellular matrix deposition in the remodeling stage. Based on this property, Cur-ZIF8-HA has superior efficacy in healing bacterially infected burn wounds in vivo. This work provides a self-adaption release system with antibacterial wound-healing properties and prevents scarring functional based on the ZIF8-HA nano-vehicle, which opens a new way for the clinical application of curcumin for burn healing.

Natural and Synthetic Clay Minerals in the Pharmaceutical and Biomedical Fields

“…Nanocomposites based on different types of zeolites and polymers were proposed in the literature and alginate [ 146 ], gelatin/agarose [ 147 ], pectin [ 148 ], hyaluronic acid [ 149 ], ethylcellulose/polyvynil pyrrolidone [ 150 ], and Pluronic F127/chitosan [ 151 ] were considered. In particular, a bone scaffold based on alginate and ZSM-5 and loaded with vancomycin demonstrated superior antibacterial activity against S. aureus and excellent osteoblast adhesion and calcium deposition, as shown in Figure 15 [ 146 ].…”

“…Nanoparticles based on a hyaluronic-acid-modified zeolite loaded with imidazole and curcumin for the treatment of burns were manufactured to control the abnormal extracellular matrix deposition in the remodeling stage. This possesses a remarkable antibacterial activity against P. aeruginosa , S. aureus, and E. coli and simultaneously was able to enhance fibroblast proliferation and angiogenesis [ 149 ].…”

ZIF‐8 Based Active Wound Dressing for pH Modulation and pH‐Responsive Delivery of Curcumin and Zn2+: Effect of Acidity on the Drug Release for Antibacterial and Antioxidant Efficacy

“…Thus, one of the potential applications of ZIF‐8 is a pH‐responsive drug carrier of an anti‐inflammatory therapeutic agent, as the wound site is usually acidic with pH of 5.0–6.0 in the early stage of healing process. [ 8–11 ]…”

“…Thus, one of the potential applications of ZIF-8 is a pH-responsive drug carrier of an anti-inflammatory therapeutic agent, as the wound site is usually acidic with pH of 5.0-6.0 in the early stage of healing process. [8][9][10][11] Curcumin (CCM) is a naturally derived anti-inflammatory phytochemical that has been extensively studied for its ability to prevent oxidative stressinduced inflammation via anti-oxidant activity. [12,13] Also, it suppresses inflammation-inducing enzymes such as tumor necrosis factor-𝛼 (TNF-𝛼), interleukin-1 (IL-1), and NF-𝜅B.…”

Coating Methods of Carbon Nonwovens with Cross-Linked Hyaluronic Acid and Its Conjugates with BMP Fragments

“…The potential of hyaluronic acid-based hydrogels was also tested for wound healing. Such materials, enriched with fibroblast growth factor (βFGF) [ 23 ] or active substances (gentamicin [ 24 ], curcumin [ 25 ]), have demonstrated positive results with regard to the quality of reconstructed skin (reduced scarring) and reduced recovery time, including after burns. The applicability of hyaluronic acid has also been tested in the form of nanocarriers.…”