Hybrid artificial cell-mediated epigenetic inhibition in metastatic lung cancer

Efficient Photoacoustic Imaging With Biomimetic Mesoporous Silica-Based Nanoparticles

“…These results showed that CMI displayed the strongest PA intensity in the tumor site, demonstrating that CMI could specifically accumulate into the tumor. The superior PA imaging efficacy of CMI might be attributed to the EPR effect via MSN loading and homologous binding ability via CCM coating ( Peng et al, 2021 ).…”

“…Various cell types, including red blood cells (RBC) ( Dehaini et al, 2017 ; Kim et al, 2020 ), platelets ( Dehaini et al, 2017 ; Kunde and Wairkar, 2021 ), white blood cells ( Yaman et al, 2020 ), cancer cells ( Yang et al, 2018 ) and stem cells ( Defterali et al, 2016 ), have been coated with the nanoparticles ( Fang et al, 2018 ). In comparison with polymer coating, cell membranes coated with nanoparticles exhibited low immunogenicity and excellent homologous targeting ability ( Fang et al, 2018 ; Li et al, 2020 ; Lin et al, 2021 ; Peng et al, 2021 ). For cancer diagnosis and treatment, based on the homologous targeting ability, nanoparticles coated with the cancer cell membrane from homologous cells could efficiently deliver drugs and probes to the tumors ( Fang et al, 2018 ; Zhang L. et al, 2020 ).…”

Cell-derived membrane biomimetic nanocarriers for targeted therapy of pulmonary disease

“…Therefore, the combination of different cell membranes may provide multiple functions. For example, Peng et al camouflaged the nanoparticles with a mixed membranes of RBCs and metastatic NCI-H1299 lung cancer cells (HRPD), which not only prolonged the circulation time, but also enhanced targeting ability ( Peng et al, 2021 ). Another example is the fusion of membranes from RAW264.7 and 4T1 cells.…”

“… Strategy Cell membrane Modifier Nanoparticle Effects Ref. Lipid insertion RBC HA-DOPE PTX, IR780 Actively targeting A549 cells ( Zhang et al, 2021c ) RBC RGD-PEG-DSPE CS-6, DOX Actively targeting TNBC cells ( Fan et al, 2020 ) RBC RGD-PEG-DSPE Black phosphorus Improving tumor targeting by specifically recognizing ανβ 3 ( Zhong et al, 2021 ) RBC cRGD-PEG-DSPE DACHPt, ICG Actively targeting cancer tissues, enhancing tumor-specific cellular uptake ( Liu et al, 2018b ) RAW 264.7 T7-PEG-DSPE Saikosaponin D/PLGA Targeting ligands transfer ferritin receptors overexpressed in tumor cells ( Sun et al, 2020 ) RBC DIR PTX-PN Providing powerful heat energy and promoting the release of core drugs under laser irradiation ( Su et al, 2016 ) A549 Liposome with MMP-9-sensitive peptide PC@CO-LC Promoting tumor cell penetration, pH triggered membrane rupture and drug release ( Zhang et al, 2021b ) Membrane hybridization RBC NCI-H1299 lung cancer cell PLGA/DOTAP/SAHA Prolonging blood circulation time and homotype targeting of metastatic cells ( Peng et al, 2021 ) 4T1 RAW 264.7 DOX/PLGA Accumulating at inflammation sites and targeting specific metastasis ( Gong et al, 2020 ) Metabolic engineering 4T1 Azide-cho, anti-CD205 MNCs Preferentially recognized by CD8+ dendritic cells ( …”

A Novel Biomimetic Nanoprobe as a Photoacoustic Contrast Agent

“…Thus, developing novel probes to overcome current obstacles is demanding. Recently, biomimetic functionalization engineering NPs have shown superior biocompatibility and smart targeting to desired tissues (Zhang et al, 2020a;Peng et al, 2021). Specifically, biomimetic NPs with cell membrane coating manifest cellmaterial hybrid nanoplatforms that combine the advantages of both natural and synthetic elements (Kroll et al, 2017;Zhang et al, 2020b).…”