2014
DOI: 10.1002/adma.201403712
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Hybrid ZnO Nanorod‐Polymer Brush Hierarchically Nanostructured Substrate for Sensitive Antibody Microarrays

Abstract: A hierarchically nanostructured organic-inorganic hybrid substrate comprising randomly oriented ZnO nanorods on glass slide with coaxially tethered dense polymer brush, POEGMA-co-GMA is reported for highly sensitive antibody microassay, achieving excellent detection specificity, and superior detection limit of as low as 100 fg mL(-1) for biomarkers in human serum within a 1 h assay time.

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Cited by 73 publications
(69 citation statements)
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“…Besides the chemical modification of the ZnO NR surface via covalent derivatization, biologically recognizable moieties, such as biotin-streptavidin and polyvalent directed peptide, have also been incorporated to increase the NR selectivity toward specific target bioanalytes (5860). In other cases, polymers and metal nanoparticles in conjunction with ZnO NRs have been used to increase biomolecular adsorption with the help of polymer brush chains (61) and to detect the signal more efficiently via the incorporation of a highly reflecting metal layer (62). In addition, ZnO NRs exhibiting an isoelectric point (pI) of ~9–10 allow for easy physical immobilization of low-pI biomolecules via electrostatic interactions at physiological pH (21).…”
Section: Biomedically Relevant Optical Properties Of Zno Nanorodsmentioning
confidence: 99%
“…Besides the chemical modification of the ZnO NR surface via covalent derivatization, biologically recognizable moieties, such as biotin-streptavidin and polyvalent directed peptide, have also been incorporated to increase the NR selectivity toward specific target bioanalytes (5860). In other cases, polymers and metal nanoparticles in conjunction with ZnO NRs have been used to increase biomolecular adsorption with the help of polymer brush chains (61) and to detect the signal more efficiently via the incorporation of a highly reflecting metal layer (62). In addition, ZnO NRs exhibiting an isoelectric point (pI) of ~9–10 allow for easy physical immobilization of low-pI biomolecules via electrostatic interactions at physiological pH (21).…”
Section: Biomedically Relevant Optical Properties Of Zno Nanorodsmentioning
confidence: 99%
“…Thanks to the high detection precision, anti-interference and running stability of gas sensor detection method, [20][21][22] it becomes an innovative method to detect the insulation status of insulation equipment in real time. Several studies proved that air would decompose to many decomposition components: CO, NO, NO 2 and O 3 under discharge.…”
Section: -2mentioning
confidence: 99%
“…Minimized motors retain the property of their macroscale counterparts on harvesting different types of energy namely thermal [ 1 , 2 ], electrical [ 3 , 4 ], magnetic [ 5 , 6 , 7 ], chemical [ 8 , 9 , 10 ], ultrasound [ 11 , 12 ], light [ 13 , 14 ] power and so on, transferring into kinetic energy to carry out complex operations. Liquid metal, typically Gallium-based alloys, inherited with favorable fluidity, high thermal and electrical conductivity, large surface tension, low toxicity, and other excellent physical and chemical properties, has attracted huge interest across various fields, like chip cooling [ 15 ], nerve connection [ 16 ], drug delivery [ 17 ], flexible electronics [ 18 ], soft-bodied robot [ 19 , 20 ], micro pump [ 21 ], etc. Tiny liquid metal motors can be driven by the electric field, allowing its biocompatibility superior to those fueled by traditional toxic solution.…”
Section: Introductionmentioning
confidence: 99%