Hydraulic Conductivity of Smooth Muscle Cell-Initiated Arterial Cocultures

Mathura, Rishi A.; Russell-Puleri, Sparkle; Cancel, Limary M.; Tarbell, John M.

doi:10.1007/s10439-015-1421-5

Ann Biomed Eng

2015

DOI: 10.1007/s10439-015-1421-5

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Hydraulic Conductivity of Smooth Muscle Cell-Initiated Arterial Cocultures

Rishi A. Mathura

Sparkle Russell-Puleri

Limary M. Cancel

et al.

Abstract: The purpose of the study was to examine the effects of arterial coculture conditions on the transport properties of several in vitro endothelial cell (EC) – smooth muscle cell (SMC) – porous filter constructs in which SMC were grown to confluence first and then EC were inoculated. This order of culturing simulates the environment of a blood vessel wall after endothelial layer damage due to stenting, vascular grafting or other vascular wall insult. For all coculture configurations examined, we observed that hyd… Show more

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Cited by 2 publications

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“…or, equivalently, Parameter c H , the hydraulic conductance of the VSMC membrane, can be taken from [44]. Indeed, according to Fig.…”

mentioning

confidence: 99%

Propagation of Acoustic Waves Caused by the Accelerations of Vibrating Hand-Held Tools in Viscoelastic Soft Tissues of Human Hands and a Mechanobiological Picture for the Related Injuries

Mamontov¹,

Berbyuk²

2017

JAMP

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As is well known, hand-arm vibration syndrome (HAVS), or vibration-induced white finger (VWF), which is a secondary form of Raynaud's syndrome, is an industrial injury triggered by regular use of vibrating hand-held tools. According to the related biopsy tests, the main vibration-caused lesion is an increase in the thickness of the artery walls of the small arteries and arterioles resulted from enlarged vascular smooth muscle cells (VSMCs) in the wall layer known as tunica media. The present work develops a mechanobiological picture for the cell enlargement. The work deals with acoustic variables in solid materials, i.e., the non-equilibrium components of mechanical variables in the materials in the case where these components are weakly non-equilibrium. The work derives an explicit expression for the infinite-time cell-volume relative enlargement. This enlargement is directly affected by the acoustic pressure in the soft living tissue (SLT). In order to reduce the enlargement, one can reduce either the ratio of the acoustic pressure in the SLT to the cell bulk modulus or the relaxation time induced by the cell osmosis, or both the characteristics. Also, a mechanoprotective role of the above relaxation time in the cell-volume maintenance is noted. The above mechanobiological picture focuses attention on the pressure in an SLT and, thus, modeling of propagation of acoustic waves caused by the acceleration of a vibrating hand-held tool. The present work analyzes the propagation along the thickness of an infinite planar layer of an SLT. The work considers acoustic modeling. As a general viscoelastic acoustic model, the work suggests linear non-stationary partial integro-differential equation (PIDE) for the weakly non-equilibrium component of the average normal stress (ANS) or, briefly, the acoustic ANS. The PIDE is, in the exponential approximation for the normalized stress-relaxation function (NSRF) reduced to the third-order linear non-stationary partial differential equation (PDE), which is of the Zener type. The unique advantage of the PIDE is that it presents a compact model for the acoustic ANS in an SLT, which explicitly includes the NSRF, thereby enabling a consistent description of the lossy-propagation effects inherent in SLTs. The one-spatial-coordinate version of this PDE in the planar SLT layer with the corresponding boundary conditions is considered. The relevance of these settings is motivated by a conclusion of other authors, which is based on the results of the frequency-domain simulation in three spatial coordinates. The boundary-value problem at arbitrary value of the stress-relaxation time (SRT) and arbitrary but sufficiently regular shape of the external acceleration is analytically solved by means of the Fourier method. The obtained solution is the steady-state acoustic ANS and allows calculation of the corresponding steady-state acoustic pressure as well. The derived analytical representations are computationally implemented. Propagation of the pressure waves in the SLT layer at zero ...

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“…or, equivalently, Parameter c H , the hydraulic conductance of the VSMC membrane, can be taken from [44]. Indeed, according to Fig.…”

mentioning

confidence: 99%

Propagation of Acoustic Waves Caused by the Accelerations of Vibrating Hand-Held Tools in Viscoelastic Soft Tissues of Human Hands and a Mechanobiological Picture for the Related Injuries

Mamontov¹,

Berbyuk²

2017

JAMP

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show abstract

A microfluidic platform with permeable walls for the analysis of vascular and extravascular mass transport

Manneschi

Pereira

Marinaro

et al. 2016

Microfluid Nanofluid

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Hydraulic Conductivity of Smooth Muscle Cell-Initiated Arterial Cocultures

Cited by 2 publications

References 36 publications

Propagation of Acoustic Waves Caused by the Accelerations of Vibrating Hand-Held Tools in Viscoelastic Soft Tissues of Human Hands and a Mechanobiological Picture for the Related Injuries

Propagation of Acoustic Waves Caused by the Accelerations of Vibrating Hand-Held Tools in Viscoelastic Soft Tissues of Human Hands and a Mechanobiological Picture for the Related Injuries

A microfluidic platform with permeable walls for the analysis of vascular and extravascular mass transport

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