Hydroalcoholic extract of Zizyphus jujuba ameliorates seizures, oxidative stress, and cognitive impairment in experimental models of epilepsy in rats

Effects of a lyophilized aqueous extract of Feretia apodanthera Del. (Rubiaceae) on pentylenetetrazole-induced kindling, oxidative stress, and cognitive impairment in mice

“…Feretia apodanthera provided protection against the development of seizures as a result of which acetylcholinesterase and butyrylcholinesterase activity was not decreased but instead increased. This finding is in accordance with a previous study in which AChE activity was reported to decrease PTZ-induced seizures [54,55]. Taken together, we suggest that F. apodanthera had ameliorating effects on memory dysfunction and antagonized cognitive impairment.…”

Interaction profile of Zizyphus jujuba with phenytoin, phenobarbitone, and carbamazepine in maximal electroshock‐induced seizures in rats

“…Extraction of the fruit was done as described previously [8]. The hydroalcoholic extract was obtained as a lyophilized powder.…”

“…Traditionally, Zizyphus jujuba (Z. jujuba) has been used as an anticonvulsant and for the treatment of anxiety and insomnia in folk medicine in India [4][5][6]. Sedative, tranquilizing, hypnotic, and antiepileptic effects of Z. jujuba in experimental models in rats have been reported [7][8][9][10]. Pre-treatment with oleomide isolated from Z. jujuba has been reported to reverse scopolamine-induced memory impairment [11].…”

“…Pre-treatment with oleomide isolated from Z. jujuba has been reported to reverse scopolamine-induced memory impairment [11]. Recently, we have shown the protective effect of hydroalcoholic extract of fruit of Z. jujuba against pentylenetetrazole and maximal electroshock-induced seizures, oxidative stress, and cognitive impairment in rats [8]. Phenytoin, phenobarbitone, and carbamazepine are the first line drugs used for the management of generalized tonic-clonic seizures [12,13].…”

Potentiation of Antiepileptic Activity of Phenytoin Using Beta Carotene Against Maximal Electroshock Induced Convulsions in Mice

“…[16] ROS have been implicated in the pathogenesis of a wide variety of human diseases [17] that alter the function of genetic apparatus and can oxidize and damage nucleic acids, proteins and lipids, which are the major components of cell membranes [15] and also, lead to cell death. [18] www.wjpps.com [2]…”