Hydroazulene Diterpenes from a Dictyota Brown Alga and Their Antioxidant and Neuroprotective Effects Against Cerebral Ischemia-Reperfusion Injury

The Biodiversity of the Genus Dictyota: Phytochemical and Pharmacological Natural Products Prospectives

“…The antioxidant property of dictyol C (24) was associated with an activation of the Nrf2/ARE signaling pathway; it also showed neuroprotective effects against cerebral ischemia-reperfusion injury (CIRI) in a rat model of transient middle cerebral artery occlusion. As such, hydroazulene diterpenes could serve as lead structures for the development of novel neuroprotective agents against CIRI [127]…”

Marine natural products

“…All the isolates showed weak to moderate cytotoprotective effects against oxidative stress caused by H 2 O 2 exposure in neuronallike PC12 cells. 379 Ten new diterpenoids 920-929, mostly belonging to the secospatane class, were obtained from a Spanish Rugulopteryx okamurae, 380 while an Australian Cystophora provided a series of new sterols 930-935. 381 A review of the chemistry of the Ochrophyta genus Turbinaria has been published, 382 as has a review of Ochrophyta polyphenols as modulators of metabolic disorders.…”

“…All the isolates showed weak to moderate cytotoprotective effects against oxidative stress caused by H 2 O 2 exposure in neuronal-like PC12 cells. 379 …”

Antioxidant and Neuroprotective Xenicane Diterpenes from the Brown Alga Dictyota coriacea

“…Some natural products derived from terrestrial plants, such as britanin, swertiamain, and dl-3- n -butylphthalide, have proven to be able to prevent and mitigate CIRI by activating Nrf2 and enhancing antioxidant gene expression in the preclinical studies. However, the potential of marine natural products as novel neuroprotective antioxidants against CIRI has been rarely studied yet …”

“…Marine brown algae of the genus Dictyota (family Dictyotacea) are a rich source of diterpenes with diverse scaffolds, many of which are biologically active (cytotoxic, antibacterial, antiviral, and antioxidant properties ,− ). Previously, we reported the structure elucidation of dictyospiromide, a unique spirosuccinimide alkaloid with antioxidant properties that are associated with the activation of the Nrf2/ARE signaling pathway from the EtOAc extract of D. coriacea .…”