Hydrocarbon exposure and tubular damage: additional factors in the progression of renal failure in primary glomerulonephritis

Yaqoob, Muhammad; Stevenson, A.; Mason, H. J.; Bell, G. H.

doi:10.1093/qjmed/86.10.661

Cited by 34 publications

(15 citation statements)

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“…The steep positive gradient for average exposure and mortality from all nonmalignant diseases of the genitourinary system, and the less steep gradient for cumulative exposure, are in agreement with the results of previous human studies (8,(13)(14), which associated exposure to high levels of organic solvents with the occurrence of acute tubular necrosis, progressive glomerulonephritis, and chronic glomerulonephritis. Much of the evidence from epidemiologic studies is limited, however, by problems in the diagnoses and uncertainties about the quality and intensity of the solvent exposure.…”

Section: Discussionsupporting

confidence: 90%

“…This proportion is about what would be expected froin national mortality statistics. Nephritis and nephrosis are of special interest, considering recent case-referent studies associating these diseases with exposure to solvents (7,14). Although the numbers were small, there was a significant increase in mortality from these diseases with an increasing average level of exposure to styrene.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Exposure to styrene and mortality from nonmalignant diseases of the genitourinary system

Welp

Partanen

Kogevinas

et al. 1996

Scand J Work Environ Health

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Section: Discussionsupporting

confidence: 90%

Section: Discussionmentioning

confidence: 99%

Exposure to styrene and mortality from nonmalignant diseases of the genitourinary system

Welp

Partanen

Kogevinas

et al. 1996

Scand J Work Environ Health

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“…In several human studies, prolonged exposure to hydrocarbons has also been found to be associated with a variety of severe glomerular lesions, including mild to severe glomerular nephritis (GN) and Goodpasture's syndrome [110][111][112][113][114][115]. Evidently, hydrocarbon exposure may indeed induce GN and worsen its course, and hence renal function, in many patients [116].…”

Section: Nephrotoxicitymentioning

confidence: 99%

Recent advances in occupational and environmental health hazards of workers exposed to gasoline compounds

Ekpenyong

Asuquo

2017

Int J Occup Med Environ Health

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The impact of health and environmental hazards, associated with the constituents of gasoline, on occupationally exposed workers has been recorded over the past few decades. However, the scientific literature on their pathogenic potential remains incomplete, which could affect the current understanding of the associated health risks. This review provides current information based on recently improved research techniques to evaluate gasoline toxicity profiles for humans. Our current knowledge provides insight into the intricate mechanism of gasoline-induced adverse effects, including the formation of reactive metabolites via bio-activation and subsequent generation of reactive oxygen species (ROS) and oxidative stress, which are involved in multiple mechanisms that are central to the aetiology of gasoline-induced toxicity. These mechanisms include covalent binding to deoxyribonucleic acid (DNA), leading to oxidative damage, tumor-suppression gene activity, and activation of pro-oncogenes. Furthermore, it results in induction of autoimmunity and local inflammatory responses, disruption of multiple neurotransmitters and immune cell function, derangement of various enzyme activities (e.g., sodiumpotassium adenosine triphosphate (Na + /K + /ATPase) activity, cytochrome P450 (CYP450), nitric oxide synthase (NOS), antioxidant enzyme activities, etc.), conjugation of bile, and non-specific cell membrane interaction, leading to damage of the membrane lipid bilayer and proteins. Available data suggests that exposure to gasoline or gasoline constituents have the potential to cause different types of illnesses. The data highlights the need to maintain safety measures via suitable research, medical surveillance, regulatory control, life style modification, early detection, and intervention to minimize exposure and manage suspected cases. They also present novel opportunities to design and develop effective therapeutic strategies against gasoline-induced detrimental effects. Int J Occup Med Environ Health 2017;30(1):1-26

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“…only 5/39 among those with stable renal function 12 . In a third study, the patients were asked to discontinue their exposure.…”

Section: All Authors Contributed To Conception and Design Manuscriptmentioning

confidence: 95%

“…A strong argument for hydrocarbons being the cause of renal failure in GN is that renal function improves if the exposure is discontinued [11][12][13] . In one study, 50 patients were followed for 7-8 years.…”

Section: The Role Of the Immunological Processesmentioning

confidence: 99%

The crucial role of tubulotoxic chemicals in renal failure

Ravnskov¹

2013

OA Nephrology

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Hydrocarbon exposure and tubular damage: additional factors in the progression of renal failure in primary glomerulonephritis

Cited by 34 publications

References 0 publications

Exposure to styrene and mortality from nonmalignant diseases of the genitourinary system

Exposure to styrene and mortality from nonmalignant diseases of the genitourinary system

Recent advances in occupational and environmental health hazards of workers exposed to gasoline compounds

The crucial role of tubulotoxic chemicals in renal failure

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