Hydrocarbon exposure, hypertension and kidney function tests

Abstract

Control and hydrocarbon exposed workers participated in a cross-sectional study about the nephrotoxicity of chronic hydrocarbon exposure. Different markers of glomerular and tubular function as well as the celluria were examined and compared. The results show that the interaction between hypertension and hydrocarbon exposure has an influence on the kidney function. For the clearance the interaction age-exposure seems to play a more important role than age or exposure alone. The most useful markers appear to be the albuminuria, the N-acetyl-beta-D-glucosaminidase activity, the retinol-binding-protein concentration and the creatinine clearance.

Immunologic and renal markers among photogravure printers exposed to toluene

“…Both of these factors limited any preanalytic variations between the subjects. Subjects with hypertension were not systematically excluded, so that we could study the possibility of an interaction between hypertension and exposure, as suggested by Hotz et a1 (23). No significant interaction was observed, but, when the subjects with hypertension were excluded, the relation between cumulative toluene exposure and urinary NAG, which was at the borderline of statistical significance, disappeared.…”

Nephrotoxicity of organic solvents: biomarkers for early detection

“…The sequence of studies within the blocks of substances is arranged according to exposure concentration (in ascending order). Abbreviations of study authors: Ho90 Hotz et al (1990), Fr83 Franchini et al (1983), St98 Stengel et al (1998), Ng90 Ng et al (1990), Vi87a Viau et al (1987a, VH98 Verplanke and Herber (1998), two groups; Vy89 Vyskocil et al (1989), Mu81 Mutti et al (1981), Vi87b Viau et al (1987b), Ge97 Ge´rin et al (1997. cf.…”

“…cf. Tables 2 and 4.1 urine of workers exposed to solvents and of controls (Hotz et al 1990;Viau et al 1987a;Verplanke and Herber 1998;Mutti et al 1992;Ge´rin et al 1997;Askergren et al 1981;Boogaard et al 1993;Boogaard and Caubo 1994;Hashimoto et al 1991;Normand et al 1989Normand et al , 1990. The range of values or the standard deviation was frequently higher in workers than in controls and, in addition, higher than the range considered as normal.…”

“…Workers with a history of kidney disease or nonwork related risk factors for developing kidney disease such as diabetes mellitus, hypertension, chronic nephritis, renal stones, use of analgesics or possibly nephrotoxic drugs (e.g. diclofenac and ibuprofen) were excluded from several studies (Hotz 1994;Hotz et al 1990;Yaqoob et al 1993a;Viau et al 1987a;Verplanke and Herber 1998;Verplanke et al 1999;Mutti et al 1992;Stengel et al 1998;Meyer et al 1984;Nagaya et al 1989;Zschiesche and Triebig 1990).…”

“…Current exposure was assessed by regular measurement of the exposure concentrations at the workplaces, and in some studies additionally by biomonitoring. If no measurements were available, special exposure scores had been developed, which considered the different types of work (Hotz et al 1990(Hotz et al , 1991(Hotz et al , 1993(Hotz et al , 1997Yaqoob et al 1993a, b). Urine samples were taken at different times and frequencies, i.e.…”