Hydrodynamically Driven Self‐Assembly of Giant Vesicles of Metal Nanoparticles for Remote‐Controlled Release

He, Jie; Wei, Zengjiang; Wang, Lei; Tomova, Zuleykhan; Babu, T G Satheesh; Wang, Chaoyang; Han, Xiaojun; Fourkas, John T.; Nie, Zhihong

doi:10.1002/anie.201208425

Cited by 120 publications

(131 citation statements)

References 62 publications

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“…This represented one of the rst steps towards single-cell drug delivery and targeted release of liposomal content, both of which have been studied extensively in the last couple of years and should only continue to be extended into the future. [136][137][138] Sensing There has been a huge progress recently in harnessing the properties of gold and silver nanoparticles for label-free sensing and spectroscopy. 139,140 Gold nanoparticles in particular are ideal tools for sensing applications because they are stable in water, do not easily oxidize, and their optical properties, which can be tuned by varying their size and shape, are strongly sensitive to the dielectric properties of the medium surrounding them.…”

Section: Manipulation Of Biomimetic and Biological Systemsmentioning

confidence: 99%

Optical trapping and manipulation of plasmonic nanoparticles: fundamentals, applications, and perspectives

et al. 2014

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This feature article discusses the optical trapping and manipulation of plasmonic nanoparticles, an area of current interest with potential applications in nanofabrication, sensing, analytics, biology and medicine. We give an overview over the basic theoretical concepts relating to optical forces, plasmon resonances and plasmonic heating. We discuss fundamental studies of plasmonic particles in optical traps and the temperature profiles around them. We place a particular emphasis on our own work employing optically trapped plasmonic nanoparticles towards nanofabrication, manipulation of biomimetic objects and sensing.

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Section: Manipulation Of Biomimetic and Biological Systemsmentioning

confidence: 99%

Optical trapping and manipulation of plasmonic nanoparticles: fundamentals, applications, and perspectives

et al. 2014

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“…In addition, the use of low-power LED light did not break the structure of the iodinated silica-porphyrin hybrid nanoparticle host, 48) whereas lasers used in many previous reports cause degradation of the photosensitizer or melting of metal nanoparticles used as heating bodies. 87)89) The singlet oxygen and heat generated from the iodinated silica-porphyrin hybrid nanoparticles destroy cancer cells. Thus, as described in Section 3.3.3, the hybrid nanoparticles injected intravenously accumulate in tumors and facilitate their visualization (Fig.…”

Section: )mentioning

confidence: 99%

Multifunctional silica-based hybrid nanoparticles for biomedical applications

Hayashi

2016

J. Ceram. Soc. Japan

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Multifunctional nanoparticles have contributed to several advances in the biomedical field. For example, many have been shown to provide higher level analysis in fundamental studies on cancer and regenerative medicine. Application of multifunctional nanoparticles as contrast agents or probes for diagnostic imaging enables integration of various imaging modalities which provides greater detail and more accurate information for diagnosis. In addition, these multifunctional materials may help researchers and clinicians combine diagnostics and treatment, called theranostics or image-guided therapy, for minimally invasive treatment of metastatic and minute cancers. Based on the viewpoint of the toxicity and the easily-controlled surface characteristics, shape, and internal function of silica-based hybrid nanoparticles, this review describes that the hybrid nanoparticles break ground for various analytical methods for fundamental studies, diagnostic techniques, and therapies. In particular, the present review focuses on seamless imaging, dual-modal imaging, and image-guided therapy using silica-based multifunctional hybrid nanoparticles with visible and near-infrared fluorescence, as well as X-ray-absorbing, photoresponsive, drug-releasing, and photoinduced heat-and reactive oxygen species-generating capabilities.

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“…sensors, [13][14][15] photovoltaic devices, 16,17 bioimaging, 18,19 and cancer therapy. [20][21][22] Engineering the surface ligands of ACMs (e.g. chemical compositions, density and distribution) is a facile, efficient way to control the site-specific interactions between neighboring metal NPs and/or the surrounding medium, [23][24][25][26][27][28][29][30] thus resulting in their self-organization in a controlled/directed manner.…”

Section: Introductionmentioning

confidence: 99%

pH-programmable self-assembly of plasmonic nanoparticles: hydrophobic interaction versus electrostatic repulsion

Kanyó

Kuo

et al. 2015

Nanoscale

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We report a general strategy to conceptualize a new design for the pH-programmable self-assembly of plasmonic gold nanoparticles (AuNPs) tethered by random copolymers of poly(styrene-co-acrylic acid) (P(St-co-AA)). It is based on using pH as an external stimulus to reversibly change the surface charge of polymer tethers and to control the delicate balance of interparticle attractive and repulsive interactions. By incorporating -COOH moieties locally within PSt hydrophobic segments, the change in the ionization degree of -COOH moieties can dramatically disrupt the hydrophobic attraction within a close distance. pH acts as a key parameter to control the deprotonation of -COOH moieties and "programs" the assembled nanostructures of plasmonic nanoparticles in a stepwise manner. At a higher solution pH where -COOH groups of polymer tethers became highly deprotonated, electrostatic repulsion dominated the self-assembly and favored the formation of end-to-end, anisotropic assemblies, e.g. 1-D single-line chains. At a lower pH, the less deprotonated -COOH groups led to the decrease of electrostatic repulsion and the side-to-side aggregates, e.g. clusters and multi-line chains of AuNPs, became favorable. The pH-programmable self-assembly allowed us to engineer a "manual" program for a sequential self-assembly by changing the pH of the solution. We demonstrated that the two-step pH-programmable assembly could generate more sophisticated "multi-block" chains using two differently sized AuNPs. Our strategy offers a general means for the programmable design of plasmonic nanoparticles into the specific pre-ordained nanostructures that are potentially useful for the precise control over their plasmon coupling.

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Hydrodynamically Driven Self‐Assembly of Giant Vesicles of Metal Nanoparticles for Remote‐Controlled Release

Cited by 120 publications

References 62 publications

Optical trapping and manipulation of plasmonic nanoparticles: fundamentals, applications, and perspectives

Optical trapping and manipulation of plasmonic nanoparticles: fundamentals, applications, and perspectives

Multifunctional silica-based hybrid nanoparticles for biomedical applications

pH-programmable self-assembly of plasmonic nanoparticles: hydrophobic interaction versus electrostatic repulsion

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