Hydrogels for controlled drug delivery

Graham, N.B.; McNeill, Marion E.

doi:10.1016/0142-9612(84)90063-2

Cited by 219 publications

(47 citation statements)

References 8 publications

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“…Crosslinked polymers derived from them methods. We considered it worthwhile to study have also been shown to have a number of applicathe photocrosslinking process of PEO in more detions (i.e., wound dressings, 1 controlled-release tail in order to provide a practical method for prodrug systems, 2,3 phase transfer catalysts, 4 semiducing well-defined networks. The purpose of the permeable membranes, 5 solid electrolytes for batpresent study was to examine the role of different teries, 6 and many others).…”

Section: Introductionmentioning

confidence: 99%

Ultraviolet-induced crosslinking of solid poly(ethylene oxide)

Doytcheva

Dotcheva

Stamenova

et al. 1997

J. Appl. Polym. Sci.

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Poly(ethylene oxide) (PEO) of molecular weight from 200,000 to 2,000,000 was crosslinked by exposure to ultraviolet radiation with a high-pressure 150 W mercury lamp. Photochemical crosslinking of PEO proceeds in the presence of photoinitiators such as benzophenone and acetophenone which act as a hydrogen-abstracting agent. Gel fraction yield exceeds 90%, and the number-average molecular weight between crosslinks determined by equilibrium swelling in chloroform varies from 3,000 to 100,000. The degree of crosslinking can be controlled by changing the irradiation temperature.

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Section: Introductionmentioning

confidence: 99%

Ultraviolet-induced crosslinking of solid poly(ethylene oxide)

Doytcheva

Dotcheva

Stamenova

et al. 1997

J. Appl. Polym. Sci.

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“…Desired physical and mechanical properties of polymers are easy to enhance by adding chain extender [9] and crosslinker. In general, these hydrophilic, but water-insoluble polyurethane hydrogels are obtained by chemical crosslinking of the matrix [10] in the process of incorporation of hydrophilic soft segments, e.g. poly(ethylene glycol) (PEG) [11].…”

Section: Introductionmentioning

confidence: 99%

Nanosize effect of clay mineral nanoparticles on the drug diffusion processes in polyurethane nanocomposite hydrogels

et al. 2017

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Abstract. Studies of swelling and release of naproxen sodium (NAP) solution by polyurethane nanocomposite hydrogels containing Cloisite 30B (organically modified montmorillonite (OMMT)) have been performed. Polyurethane nanocomposite hydrogels are hybrid, nontoxic biomaterials with unique swelling and release properties in comparison with unmodified hydrogels. These features enable to use nanocomposite hydrogels as a modern wound dressing. The presence of nanoparticles significantly improves the swelling. On the other hand, their presence hinders drug diffusion from polymer matrix and consequently causes delay of the drug release. The kinetics of swelling and release were carefully analyzed using the Korsmeyer-Peppas and the modified Hopfenberg models. The models were fitted to precise experimental data allowing accurate quantitative and qualitative analysis. We observed that 0.5% admixture of nanoparticles (Cloisite 30B) is the best concentration for hydrogel swelling properties. The release process was studied using fluorescence excitation spectra of NAP. Furthermore, we studied swelling hysteresis; polymer chains have not been destroyed after the swelling and part of swelled solution with active substances which remained absorbed in the polymer matrix after the drying process. We have found that the amount of solution with NAP remained in the nanocomposite matrix is greater than in pure hydrogel, as a consequence of NAP-OMMT interactions (nanosize effect).

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“…1 Particularly, polymer gel networks generated from derivatives of PEG, namely hydrogels, have been examined and used for drug delivery and tissue engineering based on their ability to imbibe a large amount of water and their soft and rubbery consistency. [2][3][4][5] Besides these beneficial properties, PEG-based gels are known to be nontoxic, non-immunogenic and possess anti-fouling properties. 6 Due to the unique ability of PEG to block serum protein adsorption as well as the ability to prevent prokaryotic and eukaryotic cell adhesion, PEG can be further used as a surface coating material for the passivation of biomaterial surfaces.…”

Section: Introductionmentioning

confidence: 99%

Cell phenotypic changes of mouse connective tissue fibroblasts (L-929) to poly(ethylene glycol)-based gels

et al. 2013

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a Cellular responses to various gels fabricated by photoinitiated crosslinking using acrylated linear and multi-arm poly(ethylene glycol) (PEG)-based and poly(propylene glycol)-b-poly(ethylene glycol) precursors were investigated. While no protein adsorption and cell adhesion were observed on the hydrophilic PEG-based gels, protein adsorption and cell adhesion did occur on the more hydrophobic gel generated from the block copolymer precursor. Murine fibroblast viability on the poly(ethylene glycol)-based gels was studied in the course of 72 h and the results indicated no cytotoxicity. In a systematic study, extraand intracellular metabolites of the murine fibroblasts cultured on these PEG-based gels were examined by GC-MS. Distinct intra-and extracellular changes in primary metabolism, namely amino acid metabolism, glycolysis and fatty acid metabolism, were observed. Cells cultured on the polymeric gels induced more intense intracellular changes in the metabolite profile by means of higher metabolite intensities with time in comparison to cells cultured on the reference substrate (tissue culture polystyrene). In contrast, extracellular changes of metabolite intensities were comparable.

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Hydrogels for controlled drug delivery

Cited by 219 publications

References 8 publications

Ultraviolet-induced crosslinking of solid poly(ethylene oxide)

Ultraviolet-induced crosslinking of solid poly(ethylene oxide)

Nanosize effect of clay mineral nanoparticles on the drug diffusion processes in polyurethane nanocomposite hydrogels

Cell phenotypic changes of mouse connective tissue fibroblasts (L-929) to poly(ethylene glycol)-based gels

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