Hydrogels of poly(vinyl alcohol) and collagen as new bioartificial materials

Giusti, P.; Lazzeri, Luigi; Barbani, Niccoletta; Narducci, Piero; Bonaretti, A; Palla, Michela; Lelli, L.

doi:10.1007/bf00125590

Cited by 62 publications

(32 citation statements)

References 7 publications

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“…PVA is an important material because it is non-toxic, non-carcinogenic, biodegradable, biocompatible, water soluble, and non-expensive polymer [6,7]. It has been extensively commercialized and studied in the chemical and medical industries [8] for the productions of fibers, films, coatings, cosmetics, pharmaceuticals, etc.…”

Section: Introductionmentioning

confidence: 99%

Synthesis and Characterization of γ-irradiated PVA/PEG/CaCl<SUB>2 </SUB>Hydrogel for Wound Dressing

Dutta¹

2012

CHEMISTRY

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The mixtures of polyvinyl alcohol (PVA) and polyethylene glycol (PEG) with calcium chloride (CaCl 2 ) were exposed to gamma-irradiation to synthesize transparent hydrogels for wound dressing. In this system, CaCl 2 was used not only as a gelling material but also as a plasticizer. The presence of CaCl 2 enhances the effects of PEG, this synergistic effects give births a new hydrogel with improved characteristics. The water absorption capacity of the hydrogel was in the range of 350-375% after immersion in normal saline for 72 h. In vitro weight loss experiments were conducted at 37 o C in order to simulate the use of dressing on wounded skin. The enhanced thermal stability of the hydrogel was confirmed by thermogravimetric analysis (TGA). FTIR studies confirmed the cross-linking between PVA and PEG in the hydrogel. Furthermore, the microbe penetration test of the hydrogel was carried out to confirm its impermeability to bacteria. The effect of hydrogel on cell proliferation was also evaluated to ensure that the hydrogel does not release materials which might be deleterious to cell proliferation. The results showed that the hydrogel could be considered as a potential wound-dressing material.

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Section: Introductionmentioning

confidence: 99%

Synthesis and Characterization of γ-irradiated PVA/PEG/CaCl<SUB>2 </SUB>Hydrogel for Wound Dressing

Dutta¹

2012

CHEMISTRY

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“…[1][2][3] Hydrogels have been suggested for numerous applications, such as controlled delivery of drugs, 4 artificial articular cartilage 5 or vessels, 6 contact lenses, 7 wound dressings, 8,9 and many other devices. Suitability of a hydrogel for a particular application often depends on the structural and mechanical characteristics of the biomaterial.…”

Section: Introductionmentioning

confidence: 99%

Mechanical and microstructural properties of hybrid poly(ethylene glycol)–soy protein hydrogels for wound dressing applications

Snyders

Shingel²,

Zabeida

et al. 2007

J Biomedical Materials Res

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Biomimetic hydrogel made of poly(ethylene glycol) and soy protein with a water content of 96% has been developed for moist wound dressing applications. In this study, such hybrid hydrogels were investigated by both tensile and unconfined compression measurements in order to understand the relationships between structural parameters of the network, its mechanical properties and protein absorption in vitro. Elastic moduli were found to vary from 1 to 17 kPa depending on the composition, while the Poisson's ratio (approximately 0.18) and deformation at break (approximately 300%) showed no dependence on this parameter. Further calculations yielded the crosslinking concentration, the average molecular weight between crosslinks (M(C)) and the mesh size. The results show that reactions between PEG and protein create polymeric chains comprising molecules of PEG and protein fragments between crosslinks. M(C) is three times higher than that expected for a "theoretical network." On the basis of this data, we propose a model for the 3D network of the hydrogel, which is found to be useful for understanding drug release properties and biomedical potential of the studied material.

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“…[1][2][3] Most of the materials were studied in the form of thin films, obtained by casting, starting from polymeric aqueous solutions. Synthetic polymers such as poly(vinyl alcohol) or its copolymers showed that they could interact with collagen through hydrogen bonds.…”

Section: Introductionmentioning

confidence: 99%

Bioartificial materials based on blends of collagen and poly(acrylic acid)

Barbani

Lazzeri

Cristallini

et al. 1999

J. Appl. Polym. Sci.

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ABSTRACT:The interactions between soluble collagen (C) from calf skin and poly-(acrylic acid) (PAA) were studied. Mixing aqueous solutions of collagen and PAA, at various pH values (2.5-4), leads to the formation of complexes that precipitate in the form of insoluble aggregates. The effects of mixture composition, pH, and ionic strength on C/PAA complex formation were investigated by gravimetric, turbidimetric, and conductometric analysis. The experimental results indicate that the complexes form through electrostatic interactions. Homogeneous solid films with variable C/PAA ratios were obtained by casting from solutions in which the pH was adjusted just over the isoelectric point of collagen, thus avoiding the attractive ionic interactions responsible for the complexation of collagen and PAA molecules. A relevant result obtained is related to the possibility of restoring the ionic interactions between the two polymers inside the solid films. Mixture composition and pH appear to influence the thermal properties of both complexes and films.

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Hydrogels of poly(vinyl alcohol) and collagen as new bioartificial materials

Cited by 62 publications

References 7 publications

Synthesis and Characterization of γ-irradiated PVA/PEG/CaCl<SUB>2 </SUB>Hydrogel for Wound Dressing

Synthesis and Characterization of γ-irradiated PVA/PEG/CaCl<SUB>2 </SUB>Hydrogel for Wound Dressing

Mechanical and microstructural properties of hybrid poly(ethylene glycol)–soy protein hydrogels for wound dressing applications

Bioartificial materials based on blends of collagen and poly(acrylic acid)

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