Hydrogen sulfide protects testicular germ cells against heat-induced injury

Li, Guang; Xie, Zhizhong; Chua, Joelle Yan Xin; Wong, Peiyan; Bian, Jin-Song

doi:10.1016/j.niox.2014.10.005

Cited by 27 publications

(34 citation statements)

References 23 publications

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“…Varicocele Bad (Oh, Jo, Park, & Gye, 2016). In a study on heat-induced injury in rat testis, it was demonstrated that the increase in oxygen consumption rate can be altered by NaHS administration (Li et al, 2015). In the present study, NaHS administration may have changed the testicular tissue oxygen balance by increasing H 2 S levels.…”

Section: Discussionmentioning

confidence: 46%

“…In the present study, NaHS administration may have changed the testicular tissue oxygen balance by increasing H 2 S levels. In a study on heat-induced injury in rat testis, it was demonstrated that the increase in oxygen consumption rate can be altered by NaHS administration (Li et al, 2015).…”

Section: Discussionmentioning

confidence: 99%

“…It was reported that CSE is expressed in sertoli cells, spermatogonia and epididymis of rats. For instance, the therapeutic effects of H 2 S are reported in erectile dysfunction, heat-induced injury in testicular germ cells and diabetes-induced testicular dysfunction (Li, Xie, Chua, Wong, & Bian, 2015;Wang et al, 2018;Zhu et al, 2011). D,L-propargylglycine (PAG) is a well-known CSE enzyme inhibitor, which is used in this study to explore the exact role of CSE in this model of rat varicocele.…”

mentioning

confidence: 99%

“…Several studies have demonstrated the protective effects of H 2 S on disorders such as renal and reproductive system diseases (Lobb et al, 2014;Zhu et al, 2011). For instance, the therapeutic effects of H 2 S are reported in erectile dysfunction, heat-induced injury in testicular germ cells and diabetes-induced testicular dysfunction (Li, Xie, Chua, Wong, & Bian, 2015;Wang et al, 2018;Zhu et al, 2011).…”

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confidence: 99%

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Long‐term NaHS administration reduces oxidative stress and apoptosis in a rat model of left‐side varicocele

et al. 2019

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The main aim of this study was to assay the testicular H2S levels in the varicocele rat model and then to investigate the protective effects of NaHS on morphometric changes, sperm parameters, oxidative stress and apoptosis markers in rat's testis. D,L‐propargylglycine (PAG) was administrated to show the effects of cystathionine γ‐lyase enzyme (CSE) inhibition in the varicocele. Rats were assigned to four groups: (a) Sham, (b) varicocele, (c) varicocele + PAG and (d) varicocele + NaHS. Animals in varicocele + NaHS group received 30 µmol/L NaHS in drinking water for 56 days. In the varicocele + PAG group, animals received PAG 19 mg/kg twice a week. Morphometric assessment, oxidative stress markers, testicular H2S levels, sperm parameters, TUNEL assay and expression of Bax/Bcl2 were evaluated at the end of experiment. Testicular H2S levels were significantly decreased in varicocele group. NaHS significantly improved sperm parameters, morphometric characteristics and oxidative stress compared to varicocele group. Oxidative stress status deteriorated in the PAG group compared to the varicocele group. This study showed that a low testicular H2S level might play a critical role in male infertility. Thus, NaHS administration may be a promising treatment strategy for male infertility in varicocele. In addition, CSE may not be the only important enzyme in testicular H2S production.

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Section: Discussionmentioning

confidence: 46%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

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confidence: 99%

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Long‐term NaHS administration reduces oxidative stress and apoptosis in a rat model of left‐side varicocele

et al. 2019

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“…B6) as the essential co-factor and binding Hcy by means of zinc fingers [28]. It is highly active in the liver, pancreas and cerebral cortex; however, the gene expression has been also shown in murine testicular tissue [29] and granulosa cells where gene silencing causes follicular arrest [30]. CBS responds to a very peculiar mechanism of activation that renders this enzyme the epicentre of cellular metabolism.…”

Section: Introductionmentioning

confidence: 99%

Improvement of gamete quality by stimulating and feeding the endogenous antioxidant system: mechanisms, clinical results, insights on gene-environment interactions and the role of diet

Dattilo¹,

D’Amato²,

Caroppo³

et al. 2016

J Assist Reprod Genet

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Oxidative damage triggers extensive repair in gametes and thereafter in the zygote but it results in clinically relevant damage when affecting the maturation of the gametes chromatin, i.e. padlocking and epigenetic marking. It associates with defective DNA methylation and/or with oxidation of the methyl marks leading to derangement of gamete epigenetics, defects of chromatin condensation and aneuploidy. A proper feed to the one carbon cycle has the potential to stimulate the endogenous antioxidant defences, i.e. gluthatione synthesis, and to activate compensative homeostatic mechanisms restoring both the oxy-redox balance and DNA methylation, which are indeed strictly cross-regulated. This has been shown to produce measurable clinical improvements of male reproductive potential in pilot studies herein summarised. However, the effects of dietary habits and of supplementations are variable according to the individual genetic substrate, as genetic variants of several of the concerned enzymes occur with high frequency. Individual risk assessments and personalised interventions are still difficult to implement, in the meantime, a very varied diet may facilitate metabolic compensation in the majority of the cases. This review aims to report on the mechanisms of damage, on the opportunities to modulate the physiologic oxy-redox homeostasis by means of a varied diet or dietary supplements and on the open issues related to the genetic variability of the population.

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Assessment of the effect of sodium hydrogen sulfide (hydrogen sulfide donor) on cisplatin-induced testicular toxicity in rats

Azarbarz

Seifabadi

Moaiedi

et al. 2020

Environ Sci Pollut Res

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Hydrogen sulfide protects testicular germ cells against heat-induced injury

Cited by 27 publications

References 23 publications

Long‐term NaHS administration reduces oxidative stress and apoptosis in a rat model of left‐side varicocele

Long‐term NaHS administration reduces oxidative stress and apoptosis in a rat model of left‐side varicocele

Improvement of gamete quality by stimulating and feeding the endogenous antioxidant system: mechanisms, clinical results, insights on gene-environment interactions and the role of diet

Assessment of the effect of sodium hydrogen sulfide (hydrogen sulfide donor) on cisplatin-induced testicular toxicity in rats

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