Hydrogen sulfide signaling in regulation of cell behaviors

Wang, Yuehong; Yu, Ruihuan; Wu, Lingyun; Yang, Guangdong

doi:10.1016/j.niox.2020.07.002

Cited by 42 publications

(29 citation statements)

References 158 publications

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“…Due to its vasorelaxative and vasoprotective properties, H 2 S may be useful in the treatment of arterial hypertension by decreasing peripheral resistance [92]. Research on the clinical and fundamental aspects of H 2 S is in full development, particularly the relationship between the production of H 2 S and epigenetics such as DNA methylation and DNA damage repair [102].…”

Section: H 2 S In Pathophysiological Conditionsmentioning

confidence: 99%

Hyperhomocysteinemia and Cardiovascular Disease: Is the Adenosinergic System the Missing Link?

Paganelli

Mottola

Fromonot

et al. 2021

IJMS

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The influence of hyperhomocysteinemia (HHCy) on cardiovascular disease (CVD) remains unclear. HHCy is associated with inflammation and atherosclerosis, and it is an independent risk factor for CVD, stroke and myocardial infarction. However, homocysteine (HCy)-lowering therapy does not affect the inflammatory state of CVD patients, and it has little influence on cardiovascular risk. The HCy degradation product hydrogen sulfide (H2S) is a cardioprotector. Previous research proposed a positive role of H2S in the cardiovascular system, and we discuss some recent data suggesting that HHCy worsens CVD by increasing the production of H2S, which decreases the expression of adenosine A2A receptors on the surface of immune and cardiovascular cells to cause inflammation and ischemia, respectively.

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Section: H 2 S In Pathophysiological Conditionsmentioning

confidence: 99%

Hyperhomocysteinemia and Cardiovascular Disease: Is the Adenosinergic System the Missing Link?

Paganelli

Mottola

Fromonot

et al. 2021

IJMS

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“…Hydrogen sulfide (H 2 S) is a ubiquitous small gaseous mediator and its regulation and action are tightly linked to the cellular homeostasis and maintenance of health [ 10 , 11 ]. In mammals, three enzymes are responsible for H 2 S production: cystathionine γ-lyase (CSE), cystathionineβ-synthase (CBS), and 3-mercaptopyruvate sulfurtransferase (3-MST).…”

Section: Introductionmentioning

confidence: 99%

Duchenne's muscular dystrophy involves a defective transsulfuration pathway activity

et al. 2021

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Duchenne muscular dystrophy (DMD) is the most frequent X chromosome-linked disease caused by mutations in the gene encoding for dystrophin, leading to progressive and unstoppable degeneration of skeletal muscle tissues. Despite recent advances in the understanding of the molecular processes involved in the pathogenesis of DMD, there is still no cure. In this study, we aim at investigating the potential involvement of the transsulfuration pathway (TSP), and its by-end product namely hydrogen sulfide (H 2 S), in primary human myoblasts isolated from DMD donors and skeletal muscles of dystrophic ( mdx ) mice. In myoblasts of DMD donors, we demonstrate that the expression of key genes regulating the H 2 S production and TSP activity, including cystathionine γ lyase (CSE), cystathionine beta-synthase (CBS), 3 mercaptopyruvate sulfurtransferase (3-MST), cysteine dioxygenase (CDO), cysteine sulfonic acid decarboxylase (CSAD), glutathione synthase (GS) and γ -glutamylcysteine synthetase (γ-GCS) is reduced. Starting from these findings, using Nuclear Magnetic Resonance (NMR) and quantitative Polymerase Chain Reaction (qPCR) we show that the levels of TSP-related metabolites such as methionine, glycine, glutathione, glutamate and taurine, as well as the expression levels of the aforementioned TSP related genes, are significantly reduced in skeletal muscles of mdx mice compared to healthy controls, at both an early (7 weeks) and overt (17 weeks) stage of the disease. Importantly, the treatment with sodium hydrosulfide (NaHS), a commonly used H 2 S donor, fully recovers the impaired locomotor activity in both 7 and 17 old mdx mice. This is an effect attributable to the reduced expression of pro-inflammatory markers and restoration of autophagy in skeletal muscle tissues. In conclusion, our study uncovers a defective TSP pathway activity in DMD and highlights the role of H 2 S-donors for novel and safe adjuvant therapy to treat symptoms of DMD.

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“…[5][6][7][8] H 2 S influences a wide range of cellular functions, such as cell proliferation and differentiation, oxidative stress, cellular bioenergetics, and metabolism. [9][10][11][12][13][14] Perturbations of H 2 S signaling have been linked to aging and age-associated diseases, including hypertension, atherosclerosis, type 2 diabetes, osteoporosis, Alzheimer's disease, and Parkinson's disease, etc. 2,[15][16][17][18][19][20][21] H 2 S levels in humans are reported to decline during aging.…”

Section: Introductionmentioning

confidence: 99%

“…Cystathionine gamma‐lyase (CSE), cystathionine beta‐synthase (CBS), and 3‐mercaptopyruvate sulfurtransferase (3MST) contribute to the endogenous production of H 2 S in a cell and tissue‐dependent manner 5‐8 . H 2 S influences a wide range of cellular functions, such as cell proliferation and differentiation, oxidative stress, cellular bioenergetics, and metabolism 9‐14 . Perturbations of H 2 S signaling have been linked to aging and age‐associated diseases, including hypertension, atherosclerosis, type 2 diabetes, osteoporosis, Alzheimer's disease, and Parkinson's disease, etc 2,15‐21 .…”

Section: Introductionmentioning

confidence: 99%

Cystathionine gamma‐lyase/H₂S signaling facilitates myogenesis under aging and injury condition

et al. 2021

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Hydrogen sulfide (H 2 S) can be endogenously produced and belongs to the class of signaling molecules known as gasotransmitters. Cystathionine gamma-lyase (CSE)-derived H 2 S is implicated in the regulation of cell differentiation and the aging process, but the involvements of the CSE/H 2 S system in myogenesis upon aging and injury have not been explored. In this study, we demonstrated that CSE acts as a major H 2 S-generating enzyme in skeletal muscles and is significantly downregulated in aged skeletal muscles in mice. CSE deficiency exacerbated the agedependent sarcopenia and cardiotoxin-induced injury/regeneration in mouse skeletal muscle, possibly attributed to inefficient myogenesis. In contrast, supplement of NaHS (an H 2 S donor) induced the expressions of myogenic genes and promoted muscle regeneration in mice. In vitro, incubation of myoblast cells (C2C12) with H 2 S promoted myogenesis, as evidenced by the inhibition of cell cycle progression and migration, altered expressions of myogenic markers, elongation of myoblasts, and formation of multinucleated myotubes. Myogenesis was also found to upregulate CSE expression, while blockage of CSE/H 2 S signaling resulted in a suppression of myogenesis. Mechanically, H 2 S significantly induced the heterodimer formation between MEF2c and MRF4 and promoted the binding of MEF2c/MRF4 to myogenin promoter. MEF2c was S-sulfhydrated at both cysteine 361 and 420 in the C-terminal transactivation domain, and blockage of MEF2c S-sulfhydration abolished the stimulatory role of H 2 S on MEF2c/MRF4 heterodimer formation. These findings support an essential role for H 2 S in maintaining myogenesis, presenting it as a potential candidate for the prevention of age-related sarcopenia and treatment of muscle injury.

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Hydrogen sulfide signaling in regulation of cell behaviors

Cited by 42 publications

References 158 publications

Hyperhomocysteinemia and Cardiovascular Disease: Is the Adenosinergic System the Missing Link?

Hyperhomocysteinemia and Cardiovascular Disease: Is the Adenosinergic System the Missing Link?

Duchenne's muscular dystrophy involves a defective transsulfuration pathway activity

Cystathionine gamma‐lyase/H₂S signaling facilitates myogenesis under aging and injury condition

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Hydrogen sulfide signaling in regulation of cell behaviors

Cited by 42 publications

References 158 publications

Hyperhomocysteinemia and Cardiovascular Disease: Is the Adenosinergic System the Missing Link?

Hyperhomocysteinemia and Cardiovascular Disease: Is the Adenosinergic System the Missing Link?

Duchenne's muscular dystrophy involves a defective transsulfuration pathway activity

Cystathionine gamma‐lyase/H2S signaling facilitates myogenesis under aging and injury condition

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Cystathionine gamma‐lyase/H₂S signaling facilitates myogenesis under aging and injury condition