Hydrophilic acrylic intraocular lens optic opacification in a diabetic patient

Park, Dae Il; Ha, Seunggyun; Park, Seong-Bae; Lee, Sang Min

doi:10.1007/s10384-011-0074-7

Cited by 16 publications

(14 citation statements)

References 20 publications

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“…Reports suggest some systemic diseases as etiologic agents for late IOL opacification, but do not confirm their hypotheses. 9,14,15,16 We found a significant number of patients with arterial hypertension in this study, but there was no correlation between the groups with and without IOL opacification, after 4 years of follow up. Hypertension is a common finding in a senior population; however, detailed investigations of blood and aqueous chemistry in these cases would be helpful in identifying metabolic disturbances that might contribute to dystrophic calcification, mainly if it plays a role in the breakdown of the blood-aqueous barrier.…”

Section: B Discussioncontrasting

confidence: 57%

Case-control study for clinical findings on intraocular lens opacity

Jorge¹,

Jorge²,

Ventura³

et al. 2014

Medical Express

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OBJECTIVE: To evaluate clinical features of patients related to opacification of hydrophilic acrylic intraocular lenses, four years after surgery. METHODS: We evaluated six cases of late opacification of Ioflex intraocular lenses (case group) compared to 24 patients (control group) with no opacification. Both groups underwent phacoemulsification as a result of a community campaign for underprivileged people. Patients who underwent bilateral cataract surgery had only the right eye included on the study. The patients were submitted to ophthalmic examination, including measurements of corrected distance visual acuity and biomicroscopy slitlamp evaluation. Detailed medical histories were obtained. Surgical details were retrieved. RESULTS: Systemic arterial hypertension was recorded in 4 patients from the case group and 11 in the control group, with no statistically significant difference between groups. A single patient in the control group had diabetes mellitus, and so was not considered for statistical analysis. No environmental factor could be related. There were no statistically significant differences for mean visual acuity between the groups of patients regarding the evaluation periods. One eye in the control group received an Ioflex intraocular lens with the same lot number as one of the opacified lenses. CONCLUSION: No clear patient factor could be related to late Ioflex lens opacification.

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Section: B Discussioncontrasting

confidence: 57%

Case-control study for clinical findings on intraocular lens opacity

Jorge¹,

Jorge²,

Ventura³

et al. 2014

Medical Express

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“…5 However, foldable IOLs may present difficulties in IOL centration 6 or develop glistenings and undergo opacification. [7][8][9][10][11][12] In 2012, a hydrophobic foldable IOL with ring-shaped connecting bridges (Figure 1, A) between the haptic and the optic (enVista MX60, Bausch & Lomb) became available. Its design allows the surgeon to use the ringshaped connecting bridges for new fixation suture sites.…”

Section: Online Videomentioning

confidence: 99%

Scleral fixation technique using a hydrophobic foldable intraocular lens with ring-shaped connecting bridges

Rho¹,

Song²,

Sung³

et al. 2015

Journal of Cataract and Refractive Surgery

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“…We noticed a higher rate of diabetes in patients with opacification of Akreos Adapt AO IOLs (four out of six patients having concomitant diabetes). Previous studies also supported that IOL opacification was most common in patients with systemic diseases such as diabetes [ 9 , 10 ]. First of all, in cases of diabetic retinopathy (DR), where many pathological conditions such as ischemia/hypoxia, shear stress and inflammation play a role, intravitreal levels of adenosine triphosphate (ATP) are significantly increased as compared with those in non-diabetic controls [ 11 ].…”

Section: Discussionmentioning

confidence: 58%

Akreos Adapt AO Intraocular lens opacification after vitrectomy in a diabetic patient: a case report and review of the literature

et al. 2016

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BackgroundPostoperative optic opacification of hydrophilic acrylic intraocular lenses (IOLs) is an uncommon complication leading to IOL explantation. In the past decade, several studies reported that the granular deposits responsible for the opacification were probably calcium and phosphate salts; however, the exact mechanism causing calcification of IOLs is unknown. The aim of this study is to describe clinical and laboratory findings of a case of late postoperative opacification of an aspheric hydrophilic acrylic IOL (Akreos Adapt AO) after vitrectomy.Case presentationA 60-year-old woman diagnosed with cataract and severe nonproliferative diabetic retinopathy (NPDR) underwent uneventful phacoemulsification and hydrophilic acrylic IOL (Akreos Adapt AO, Bausch & Lomb) implantation in both eyes. Seven months later, the woman came back with a complaint of blurry vision in the left eye. Fundus examination revealed vitreous hemorrhage in the left eye veiling the retinal detail. A 23-gauge vitrectomy with endolaser treatment was performed in the left eye. Ten months after the vitrectomy, the patient complained of decreased visual acuity in the left eye again. On slit-lamp examination, we observed a well circumscribed centrally and paracentrally located opacification within the pupillary area localized to the anterior surface of the IOL. The IOL was explanted from the left eye together with the capsular bag, and an iris-claw lens (Artisan Aphakia OPHTEC) was implanted. The explanted IOL was examined under pathological evaluation (alizarin red method).ConclusionsIOL opacification is a rare event. We described a case of postoperative opacification of the Akreos Adapt AO IOL after vitrectomy in a patient with proliferative diabetic retinopathy and found the deposits on the anterior surface of the IOL consisted of calcium aggregates. Given the higher frequency of postoperative opacification observed in diabetic patients, hydrophilic acrylic IOLs should be used with caution in patients with diabetes.

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Hydrophilic acrylic intraocular lens optic opacification in a diabetic patient

Abstract: We believe this report of calcification of the Akreos(®) MI-60 IOL is of clinicopathological importance. Long-term follow-up of diabetic patients implanted with this IOL should be maintained by surgeons and manufacturers.

Cited by 16 publications

References 20 publications

Case-control study for clinical findings on intraocular lens opacity

Case-control study for clinical findings on intraocular lens opacity

Scleral fixation technique using a hydrophobic foldable intraocular lens with ring-shaped connecting bridges

Akreos Adapt AO Intraocular lens opacification after vitrectomy in a diabetic patient: a case report and review of the literature

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