Hydrophilic-interaction planar chromatography of some water-soluble Co(III) complexes on different adsorbents

Radoičić, Aleksandra; Majstorović, Helena; Sabo, Tibor J.; Tešić, Živoslav Lj.; Milojković‐Opsenica, Dušanka

doi:10.1556/jpc.22.2009.4.3

Cited by 13 publications

(5 citation statements)

References 16 publications

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“…Namely, in our previous paper [12] the applicability of four different hydrophilic adsorbents-unmodified silica gel, alumina, CN-silica, and cellulose in planar HILIC of some neutral, water-soluble Co(III) complexes-was studied. Silica gel appeared to be the most suitable stationary phase in broad ranges of solvent systems as well as analytes.…”

Section: Resultsmentioning

confidence: 99%

“…However, there are only a few reports regarding application of this method in planar, that is, thin-layer chromatography (TLC). [12,13] Among mentioned reports, only one describes a systematic investigation of chromatographic behavior of twelve neutral metal complexes under HILIC conditions. [12] The examinations of chromatographic behavior of different classes of metal complexes are of a special significance because of their environmental and biomedical interest.…”

Section: Introductionmentioning

confidence: 99%

“…[12,13] Among mentioned reports, only one describes a systematic investigation of chromatographic behavior of twelve neutral metal complexes under HILIC conditions. [12] The examinations of chromatographic behavior of different classes of metal complexes are of a special significance because of their environmental and biomedical interest. [14] Apart from an importance in materials science and catalysis, metal ions and their complexes are important in the vital functions of living organisms.…”

Section: Introductionmentioning

confidence: 99%

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HYDROPHILIC INTERACTION PLANAR CHROMATOGRAPHY OF GEOMETRICAL ISOMERS OF SELECTED Co(III) COMPLEXES

Shweshein

Radoičić²,

Andrić

et al. 2012

Journal of Liquid Chromatography & Related Technologies

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& The retention behavior of fourteen geometrically isomeric Co(III) complexes: three pairs of neutral facial-meridional (fac-mer) isomers, one pair of cis-trans isomeric complexes of neutral type, and three pairs of cationic cis-trans isomers have been investigated on thin-layer of silica gel. The effect of the composition of the mobile phases consisting of different ratios of water, methanol, and sodium chloride on retention of the complexes has been explored. In the broad range of mobile phase compositions, a successful separation of geometrical isomers was obtained. A retention order of isomeric complexes consistent with the mobile phase composition was found. The best resolution of isomers was achieved by using solvent systems containing 10 % water. On the basis of the results obtained, possible separation mechanisms were considered. Hydrophilic-interaction chromatography was assumed to be the mechanism determining separation in the case of mobile phases containing small amounts of both water and salt.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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HYDROPHILIC INTERACTION PLANAR CHROMATOGRAPHY OF GEOMETRICAL ISOMERS OF SELECTED Co(III) COMPLEXES

Shweshein

Radoičić²,

Andrić

et al. 2012

Journal of Liquid Chromatography & Related Technologies

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“…The theory and practice of TLC analytical tehniques have been previously discussed in detail. [1] TLC has been recently employed for the analysis of pesticides in lake water, [2] study of the behavior of some water soluble Co(III) complexes, [3] measurement of bicalutamide in bulk drug and liposomes, [4] determination of chlorogenic acid in fruits, [5] caffein in black and green teas, [6] rabeprazol and domperidone in formulations, [7] separation of aminoglycoside antibiotics (amikacin, gentamicin, kanamycin, neomycin, and tobramycin), [8] the active agents alprazolam and fluoxetine in tablets. [9] The combination of TLC with other techniques such as matrix-assisted laser desorption=ionization mass spectrometry, [10] and desorption electrospray ionisation ion mobility mass spectrometry [11] has also been reported.…”

Section: Introductionmentioning

confidence: 99%

Relationship Between the Calculated Physicochemical Parameters and Reversed Phase Thin-Layer Chromatographic Retention Behavior of Carboxamide Fungicides and Related Compounds

Oros

Cserháti

2010

Journal of Liquid Chromatography & Related Technologies

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& The lipophilicity of 6 carboxamide fungicides and 11 phenylbenzamide derivatives were determined by reversed phase layer chromatography (RP-TLC) employing silica and alumina as stationary phases impregnated with paraffin oil. Mixtures of methanol-water, acetonitrile-water, tetrahydrofurane-water, and acetone-water were used as mobile phases. The R M0 and b values related to the molecular lipophilicity and to the specific hydrophobic surface area (b) of the solutes were calculated separately for each RP-TLC system and for each analyte. The correlations between the physicochemical parameters measured were calculated by linear regression analysis. The impact of the site and character of the substituent on the retention of analytes was assessed by Free-Wilson analysis.The measured lipophilicity parameters were compared with 24 molecular descriptors computed applying free engines of the web. Calculations proved that the character of the stationary phase and the type of organic modifier exerted a negligible effect on the measured lipophilicity parameters. In the majority of cases the R M0 and b values and computed molecular descriptors were intercorrelated, but the fitness of the points to the linear regression equation was not strong enough to replace the measured values with the computed ones. This finding indicates the importance of using not only computed but also measured parameters for the future studies of both quantitative structure retention relationship (QSRR) and quantitative structure activity relationship (QSAR) calculations.

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“…Međutim, pri ispitivanju hromatografskog ponašanja izrazito polarnih jedinjenja na CN stacionarnoj fazi, uz upotrebu mobilnih faza karakterističnih za reverzno-fazne uslove (smeša vode i organskog rastvarača) retencija ispitivanih jedinjenja se smanjuje sa povećanjem udela organske komponente u mobilnoj fazi 39 . Ovakvo hromatografsko odvajanje se zasniva na hidrofilnim interakcijama koje ispitivanja jedinjenja ostvaruju sa stacionarnom, odnosno mobilnom fazom, a sama tehnika se naziva hromatografija hidrofilnih interakcija (engl.…”

Section: Uvodunclassified

Quantitative structure-retention relationship study of oxothiazolidines using multivariate analysis

Dabić¹

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Ova doktorska disertacija je urađena na Katedri za analitičku hemiju Hemijskog fakulteta Univerziteta u Beogradu, pod mentorstvom dr Živoslava Tešića, redovnog profesora Hemijskog fakulteta u Beogradu. Najiskrenije se zahvaljujem prof. dr Živoslavu Tešiću na dragocenoj pomoći u toku izrade i pisanja rada, na korisnim savetima i stručnom usmeravanju. Dr Dušanki Milojković-Opsenici dugujem izuzetnu zahvalnost na dragocenim stručnim savetima i korisnim sugestijama tokom izrade doktorske disertacije. Posebnu zahvalnost dugujem i dr Maji Natić na stalnom interesovanju, savetima i nesebičnoj pomoći pri postavci i izradi ove disertacije. Zahvaljujem se dr Mariji Baranac-Stojanović, u okviru čije grupe su sintetisane supstance ispitivane u ovoj disertaciji, na savetima pri završnoj izradi rada, kao i dr Danici Agbabi na stručnoj pomoći. Najsrdačnije se zahvaljujem i svim svojim kolegama na rečima podrške i ohrabrenja. Utvrđivanje veze između strukture i retencije oksotiazolidina primenom multivarijantne analize Hromatografsko ponašanje 23 novosintetisana 2-alkiliden-4-oksotiazolidina ispitivano je u uslovima reverzno-fazne planarne hromatografije, uz upotrebu dve stacionarne faze (oktadecil-modifikovan (RP-18) i cijano-modifikovan (CN) silika-gel). Dvokomponentne smeše methanol/voda, acetonitril/voda i tetrahidrofuran/voda su korišćene kao mobilne faze. Linearna zavisnost R M vrednosti od zapreminskog udela organske komponente u mobilnoj fazi utvrđena je za sva ispitivana jedinjenja, sa visokom vrednošću korelacionog koeficijenta (r > 0,99). Ispitivani 4-oksotiazolidini predstavljaju kongenernu seriju jedinjenja, što potvrđuje značajan nivo korelacije dobijen pri poređenju R M 0 vrednosti i drugih hromatografskih parametara (m, C 0 i PC1). Svi hromatografski parametri lipofilnosti (R M 0 , m, C 0 i PC1) poređeni su sa izračunatim log P vrednostima. Statistički parametri ovih zavisnosti pokazali su da R M 0 vrednosti mnogo pouzdanije opisuju lipofilnosti od preostalih hromatografskih parametara (m, C 0 i PC1). Analiza glavnih komponenata je primenjena na retencione podatke u cilju utvrđivanja sličnosti i razlika između upotrebljenih hromatografskih sistema. Višestruka linearna regresija (MLR) i parcijalna regresija najmanjih kvadrata (PLS) su omogućile ispitivanje odnosa između molekulskih deskriptora ispitivanih N-supstituisanih 2-alkiliden-4-oksotiazolidina i retencionih podataka određenih primenom dva hromatografska sistema (tetrahidrofuran/voda na RP-18 i CN stacionarnoj fazi). Potpuna geometrijska optimizacija izvršena je pomoću AM1 semi-empirijske molekulsko-orbitalne metode, nakon čega je set fizičko-hemijskih molekulskih deskriptora izračunat iz optimizovanih struktura. Poređenjem statističkih parametara odabran je model gde je na najbolji način opisana veza između seta izračunatih deskriptora i R M 0 vrednosti. Dobra prediktivna moć MLR i PLS modela dobijenih za kalibracioni set podataka potvrđena je na podacima iz test seta. Molekulski deskriptori uključeni u odabrane MLR i PLS modele su slične prirode, a u sve ...

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Hydrophilic-interaction planar chromatography of some water-soluble Co(III) complexes on different adsorbents

Cited by 13 publications

References 16 publications

HYDROPHILIC INTERACTION PLANAR CHROMATOGRAPHY OF GEOMETRICAL ISOMERS OF SELECTED Co(III) COMPLEXES

HYDROPHILIC INTERACTION PLANAR CHROMATOGRAPHY OF GEOMETRICAL ISOMERS OF SELECTED Co(III) COMPLEXES

Relationship Between the Calculated Physicochemical Parameters and Reversed Phase Thin-Layer Chromatographic Retention Behavior of Carboxamide Fungicides and Related Compounds

Quantitative structure-retention relationship study of oxothiazolidines using multivariate analysis

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