Hydrophobic boron compound-loaded poly(l-lactide-co-glycolide) nanoparticles for boron neutron capture therapy

Takeuchi, Issei; Nomura, Kazuhiro; Makino, Kimiko

doi:10.1016/j.colsurfb.2017.08.002

Cited by 36 publications

(43 citation statements)

References 37 publications

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“…To overcome these problems, some researchers have shown interest in preparing biodegradable boron-containing nanomedicines with the help of biodegradable polymers. This includes natural polymers such as chitosan, gelatin, albumin, collagen and alginate [74][75][76], or synthetic polymers such as poly-(ethylene glycol)-block-poly(lactide) copolymer (PEG-b-PLA), poly(D.L-lactide-co-glycolide) (PLGA), and polylactides (PLA) as coating layers [77][78][79][80], and boron compounds as boron carriers [61,[81][82][83]. These polymers undergo hydrolysis in a physiological environment due to their polyester structure.…”

Section: Development Of Novel Bnct Agentsmentioning

confidence: 99%

Boron Chemistry for Medical Applications

2020

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Boron compounds now have many applications in a number of fields, including Medicinal Chemistry. Although the uses of boron compounds in pharmacological science have been recognized several decades ago, surprisingly few are found in pharmaceutical drugs. The boron-containing compounds epitomize a new class for medicinal chemists to use in their drug designs. Carboranes are a class of organometallic compounds containing carbon (C), boron (B), and hydrogen (H) and are the most widely studied boron compounds in medicinal chemistry. Additionally, other boron-based compounds are of great interest, such as dodecaborate anions, metallacarboranes and metallaboranes. The boron neutron capture therapy (BNCT) has been utilized for cancer treatment from last decade, where chemotherapy and radiation have their own shortcomings. However, the improvement in the already existing (BPA and/or BSH) localized delivery agents or new tumor-targeted compounds are required before realizing the full clinical potential of BNCT. The work outlined in this short review addresses the advancements in boron containing compounds. Here, we have focused on the possible clinical implications of the new and improved boron-based biologically active compounds for BNCT that are reported to have in vivo and/or in vitro efficacy.

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Section: Development Of Novel Bnct Agentsmentioning

confidence: 99%

Boron Chemistry for Medical Applications

2020

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“…ticles coated with CS o-Carborane-loaded PLGA nanoparticles bare nanoparticles were prepared via an emulsion solvent evaporation method 5 . 90 mg of PLGA7510 and 10 mg of o-Carborane were briefly dissolved in a mixture of 1.0 mL of dichloromethane and 1.0 mL of acetone.…”

Section: Preparation Of O-carborane-loaded Plga Nanopar-mentioning

confidence: 99%

“…Key words: poly(DL-lactide-co-glycolide), nanoparticle, chitosan, cellular uptake, boron neutron capture therapy tumor of boron compound-loaded PLGA nanoparticles exceeded 20-30 µg/g of tissue, and the average tumor/blood boron concentration ratio exceeded 5 by 4-12 h post-tail vein injection. In addition, as a result of utilizing PLGA in nanoparticulation, the boron concentration in the tumor was 1.7-3.2 times higher than that of boron compound-albumin conjugate 5 . Although PLGA nanoparticles are thought to be useful for BNCT boron delivery, the influence of surface modification has not yet been investigated.…”

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confidence: 96%

“…For BNCT to be effective, at least 20-30 µg of nonradioactive 10 B per gram of tumor tissue and a tumor/blood boron concentration ratio above 5 are required 1 4 . In a previous study, we revealed that poly lactide-co-glycolide nanoparticles were useful for BNCT 5 . Poly lactide-co-glycolide , which is a class of biodegradable polymers, has been studied as a drug carrier because of their biocompatibility and biodegradability 6 8 .…”

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Chitosan Coating Effect on Cellular Uptake of PLGA Nanoparticles for Boron Neutron Capture Therapy

2019

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Introduction Studies on boron neutron capture therapy BNCT have recently begun garnering attention. It is a cancer treatment method that exploits the nuclear reaction between boron and thermal neutrons, and is based on nuclear capture and fission reactions. Naturally occurring elemental boron has the following two stable isotopes: boron-10 10 B and boron-11 11 B. When 10 B is irradiated with low-energy thermal neutrons, it yields high linear energy transfer LET , α particles 4 He , and recoiling lithium-7 7 Li nuclei. The destructive effects of these high-energy particles are limited to boron-containing cells since the path length of high LET particles in tissue is limited 5-9 µm. Therefore, BNCT can theoretically kill tumor cells without affecting adjacent healthy cells if 10 B atoms can be selectively delivered and accumulated in the interstitial space of

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“…The experiment was conducted in accordance with the Guidelines for Animal Experimentation of Tokyo University of Science, which are based on the Guidelines for Animal Experimentation of the Japanese Association for Laboratory Animal Science. B16 melanoma cells 1.0 106 cells in 50 µL of PBS were subcutaneously injected into a footpad of the right hind limb of mice, and tumor-bearing mice were given after 2-3 weeks 14,23,24 . The experiment started when the estimated tumor weight reached 80-100 mg.…”

Section: Biodistribution Study Of Polyborane-encapsulated Li-mentioning

confidence: 99%

Polyborane-encapsulated PEGylated Liposomes Prepared Using Post-insertion Technique for Boron Neutron Capture Therapy

et al. 2019

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Introduction Research on liposomes as drug carriers for cancer treatment has been widely conducted. Liposomes are closed vesicles formed of phospholipids which are basic components of biomembrane. They can encapsulate the lipophilic drug within the lipid bilayer and the hydrophilic drug within the aqueous core. In addition, it is also possible to incorporate both types of drugs into the same liposome formulation 1. PEGylation of liposomes has been frequently used to efficiently deliver drugs to tumors. PEGylation has the ability to decrease uptake by reticuloendothelial system, prolong blood retention, decrease degradation by metabolic enzymes, and reduce protein immunogenicity 2, 3. Strategies utilizing this are known to be useful for passive and active targeting to tumor cells 2 4. In the conventional PEG modification method, PEG lipid is added before liposome formation pre-insertion. However, this method has the problem that PEG is also modified on the membrane

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Hydrophobic boron compound-loaded poly(l-lactide-co-glycolide) nanoparticles for boron neutron capture therapy

Cited by 36 publications

References 37 publications

Boron Chemistry for Medical Applications

Boron Chemistry for Medical Applications

Chitosan Coating Effect on Cellular Uptake of PLGA Nanoparticles for Boron Neutron Capture Therapy

Polyborane-encapsulated PEGylated Liposomes Prepared Using Post-insertion Technique for Boron Neutron Capture Therapy

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