Hydrothorax in association with Scopulariopsis brumptii in an AIDS patient in Chennai, India

Abstract

Over the past decade, an increasing number of opportunistic fungal infections have been reported in immunocompromised subjects. Microascus spp. and their anamorphs Scopulariopsis spp. have been recovered from a wide geographical range. We report a case of Scopulariopsis brumptii in a 27-year-old man with AIDS presenting with breathlessness, pericardial effusion and hydrothorax in Chennai, southern India, in February 2007. Because of respiratory arrest, the patient was intubated. However, the patient developed obstructive shock and died due to cardiac dysfunctions. This report underlines the need for a direct, intensive approach to investigations in immunocompromised patients, especially those with AIDS.

Fatal Scopulariopsis brumptii in a Pediatric Immunocompromised Host

“…The five other S. brumptii case reports involved immunosuppression, three fatal [3][4][5][6][7]. In described reports, pulmonary infection is usual site of inoculation [8].…”

Successful eradication of invasive Scopulariopsis brumptii in a liver transplant recipient

“…The S. brumptii species has been most commonly linked to pulmonary infection, although data are scarce (Table ; ). All documented cases involve consistent environmental exposure, underlying immunocompromise, or both.…”

Detection and identification of human fungal pathogens using surface-enhanced Raman spectroscopy and principal component analysis

“…22 Scopulariopsis brumptii, a dematiaceous mould, has been reported as the etiologic agent of human onychomycosis 23 and sporadically invasive infections in seriously immunosuppressed patients. 24,25 Finally, C. krusei, a budding yeast, which, although rarely causes human infections, is the only Candida species inherently resistant to uconazole, one of the primary drugs used to treat candidiasis. 26 Surface-enhanced Raman spectroscopy (SERS) is a very promising technique for biomedical applications in whole organism ngerprint study.…”