Hydrotropic polymer-based paclitaxel-loaded self-assembled nanoparticles: preparation and biological evaluation

Gao, Lei; Gao, Liefang; Fan, Mingxue; Li, Qilong; Jin, Jiyu; Wang, Jing; Lu, Weiyue; Yu, Lei; Yan, Zhiqiang; Wang, Yiting

doi:10.1039/c7ra04563h

Cited by 8 publications

(9 citation statements)

References 30 publications

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“…This hydrophobic part interacts with the drug molecules, and the ionic part increases the water solubility. The solubilization method is very nuanced, and the decision can be summed up in four ways: hydrophobic interaction, accumulation of aromatic rings, formation of a hydrogen bond, and unique point-to-point interaction. ,− Paul et al reported the enhanced solubility of griseofulvin in water using hydrotrope sodium cumene sulfonate (SCS) and its delivery to the γ-tubulin protein. In the presence of SCS molecules, it has been found that the drug–protein interaction is not very strongly affected.…”

Section: Applicationmentioning

confidence: 99%

Role of Hydrotropes in Sparingly Soluble Drug Solubilization: Insight from a Molecular Dynamics Simulation and Experimental Perspectives

2021

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Drug molecules’ therapeutic efficacy depends on their bioavailability and solubility. But more than 70% of the formulated drug molecules show limited effectiveness due to low water solubility. Thus, the water solubility enhancement technique of drug molecules becomes the need of time. One such way is hydrotropy. The solubilizing agent of a hydrophobic molecule is generally referred to as a hydrotrope, and this phenomenon is termed hydrotropy. This method has high industrial demand, as hydrotropes are noninflammable, readily available, environmentally friendly, quickly recovered, cost-effective, and not involved in solid emulsification. The endless importance of hydrotropes in industry (especially in the pharmaceutical industry) motivated us to prepare a feature article with a clear introduction, detailed mechanistic insights into the hydrotropic solubilization of drug molecules, applications in pharma industries, and some future directions of this technique. Thus, we believe that this feature article will become an adequate manual for the pharmaceutical researchers who want to explore all of the past perspectives of the hydrotropic action of hydrotropes in pharmaceutics.

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Section: Applicationmentioning

confidence: 99%

Role of Hydrotropes in Sparingly Soluble Drug Solubilization: Insight from a Molecular Dynamics Simulation and Experimental Perspectives

2021

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“…The particle size determined by DLS represented the hydrodynamic diameter, whereas the results obtained by TEM were the collapsed nanoparticles aer water evaporation. 32 Moreover, the drug loading (DL) was measured to further evaluate the nanoparticles. The DL of PGA-PTX, PGA-GEM and PGA-FA were 18.6%, 19.56% and 19.4% respectively, and the experimental results were as expected as theory.…”

Section: Preparation and Characterization Of Functionalized Nanoparticlesmentioning

confidence: 99%

Co-delivery of paclitaxel and gemcitabine via a self-assembling nanoparticle for targeted treatment of breast cancer

et al. 2019

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“…In addition, it has shown a series of advantages such as high water solubility and drug-loading capacity, good biocompatibility, low toxicities, improved tumor-targeting ability, and antitumor efficacy. 13,14 To increase the tumor-targeting ability of PDCs, the most common way is to conjugate a targeting moiety to the polymer backbone by covalently chemical modification 8,15,16 to prepare a so-called actively targeting PDCs. For example, conjugation of iRGD to N-(2-hydroxypropyl)methacrylamide (HPMA) copolymer 17,18 or doxorubicin−polymer conjugates 19 resulted in an enhanced tumor accumulation and penetration.…”

Section: ■ Introductionmentioning

confidence: 99%

“…This is also in accordance with many previous reports. 13,14 According to the drug-loading equation, the PTX loaded in PGG−PTX, mPEG/PGG−PTX, and RGE−PEG/PGG−PTX NPs were 35.1%, 32.5%, and 31.6%, respectively, indicating that the modification of RGE peptide through physical encapsulation did not affect the loading capacity of the PGG−PTX delivery system. In addition, our drug-delivery system showed a good stability in vitro over 3 weeks (Figure 4).…”

Section: ■ Introductionmentioning

confidence: 99%

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Self-Assembled Tumor-Penetrating Peptide-Modified Poly(l-γ-glutamylglutamine)–Paclitaxel Nanoparticles Based on Hydrophobic Interaction for the Treatment of Glioblastoma

Sun

Zhou

et al. 2017

Bioconjugate Chem.

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To enhance the tumor-penetrating ability and targeting therapeutic effect of polymer-drug conjugates (PDCs), tumor-penetrating peptide RGERPPR (RGE) modified and PEGylated poly(l-γ-glutamylglutamine)-paclitaxel (PGG-PTX) nanoparticles (RGE-PEG/PGG-PTX NPs) were prepared by using a so-called "modular" design strategy. In brief, a RGERPPR-conjugated targeting material, DSPE-PEG-RGERPPR, was first synthesized and assembled with PGG-PTX into RGE-PEG/PGG-PTX NPs based on the hydrophobic interaction between the groups of 1,2-distearoyl-sn-glycero-3-phosphoethanolamine (DSPE) and PTX. The NPs exhibited a uniform spherical morphology with particle size of around 90 nm, as shown by the dynamic light scattering and transmission electron microscopy results. The NPs showed good in vitro stability at 4 °C for over 3 weeks, sustained drug release within 120 h, and good hemocompatibility. The cellular-uptake study displayed that the NPs showed increased uptake by U87 MG cells and human umbilical vein endothelial cells (HUVECs) compared to the unmodified PGG-PTX. The cytotoxicity test demonstrated that RGE-PEG/PGG-PTX NPs produced a stronger growth inhibitory effect against U87 MG cells and HUVECs than PGG-PTX, which was consistent with the cellular uptake results. Finally, the pharmacodynamic study proved that RGE-PEG/PGG-PTX NPs significantly prolonged the median survival time of nude mice bearing intracranial glioblastoma. The results indicated the effectiveness of RGE-PEG/PGG-PTX NPs in the treatment of glioblastoma as well as the feasibility of the "modular" design strategy in the preparation of active-targeting PDCs.

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Hydrotropic polymer-based paclitaxel-loaded self-assembled nanoparticles: preparation and biological evaluation

Abstract: Hydrotropic polymer-based paclitaxel-loaded self-assembled nanoparticles: preparation and biological evaluation.

Cited by 8 publications

References 30 publications

Role of Hydrotropes in Sparingly Soluble Drug Solubilization: Insight from a Molecular Dynamics Simulation and Experimental Perspectives

Role of Hydrotropes in Sparingly Soluble Drug Solubilization: Insight from a Molecular Dynamics Simulation and Experimental Perspectives

Co-delivery of paclitaxel and gemcitabine via a self-assembling nanoparticle for targeted treatment of breast cancer

Self-Assembled Tumor-Penetrating Peptide-Modified Poly(l-γ-glutamylglutamine)–Paclitaxel Nanoparticles Based on Hydrophobic Interaction for the Treatment of Glioblastoma

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