Hydroxyapatite-calcium sulfate-hyaluronic acid composite encapsulated with collagenase as bone substitute for alveolar bone regeneration

Sadhasivam, S.; Fang, Yen-Hsin; Savitha, S.; Lin, Fa‐Hsuan; Lin, Chun‐Pin

doi:10.1016/j.biomaterials.2015.09.044

Cited by 116 publications

(71 citation statements)

References 26 publications

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“…In recent years, an increasing attention has been paid to alternatives for bone auto‐ and allografts, including artificial polymer‐ceramics composites. Polymers, acting as elasticity‐increasing compounds in these constructs, are synthetic or natural in their nature and include polycaprolactone, polylactic acid and polylactic‐glycolic acid, gelatin, collagen, fibrin, hyaluronic acid, chitosan, starch, and curdlan . Many polymers (e.g., chitosan, starch, hyaluronic acid, and curdlan) exhibit significant water‐absorbing capacity which is crucial for the circulation of oxygen, nutrients, cytotoxic degradation products, and metabolic wastes in polymer‐based scaffolds and surrounding tissues.…”

Section: Introductionmentioning

confidence: 99%

Behavior of new hydroxyapatite/glucan composite in human serum

et al. 2018

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Biomaterials for bone tissue regeneration, including polymer-based composites, are typically evaluated in vitro prior to the clinical trials. However, such composites tested in vivo may behave different due to the specific body conditions. For example, some composites implanted into the tissue acidified due to transient postoperative inflammation may unexpectedly swell which delays the wound healing. Such massive swelling in acidic medium was previously observed for new elastic hydroxyapatite (HAp)/β-glucan biomaterial. However, in further clinical cases concerning the composite implantation in patients without significant inflammation indicators, no side effects were observed. Therefore, it was reasonable to test the effect of human serum of neutral pH (typical for noninflamed tissues) on the composite parameters, in particular volume changes. Thus, this article shows the characterization of physicochemical parameters of the composite after incubation (5 days) in human serum of neutral pH by means of weight and volume measurement, scanning electron microscopy, X-ray diffraction, Fourier-transform infrared spectroscopy, microcomputed tomography, mercury intrusion, and biochemical techniques. Results showed that human serum collected from healthy people caused no uncontrolled changes in weight and volume, porosity and mechanical properties of the composite. Therefore, this suggests the lack of volume change-related side effects of HAp/glucan composite in bone defects treatment if postoperative inflammation is prevented. © 2018 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 106B: 2653-2664, 2018.

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Section: Introductionmentioning

confidence: 99%

Behavior of new hydroxyapatite/glucan composite in human serum

et al. 2018

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“…HA also has a wide range of research and application in bone tissue engineering, it can be used as a scaf fold or molecular carrier to promote bone tissue regeneration [40,59] . The existing papers show that its application has been explored in the field of skull [60] , alveolar [61] and so on. As in cartilage tissue engineering, HA is also usually required for modification in bone tissue engineering.…”

Section: Ha In Bone Tissue Engineeringmentioning

confidence: 99%

“…Since the mechanical properties of HA are weaker than that of human natural bones, the use of HA alone as a scaffold material is not sufficient to support the cellscaffold composite and requires other materials to be compounded. For example, Subramaniam et al [61] demonstrated that HA can be compounded with hydroxyapatite (one of the components of the bone matrix) and modified with calcium sulfate, which encapsulates collagenase. The composite above can serve as a substitute for alveolar bone to produce satisfactory outcomes.…”

Section: Ha In Bone Tissue Engineeringmentioning

confidence: 99%

Hyaluronic acid: a versatile biomaterial in tissue engineering

Zhu¹,

Wang²,

Yang³

et al. 2017

PAR

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“…40 More sophisticated, combinatorial approaches have been performed, involving collagenase to stimulate mandibular bone remodeling, and HA in a hydrogel with calcium sulfide hemihydrate; a bioresorbable, osteoconductive compound. 41 …”

Section: Grafts Based On Structural Proteinmentioning

confidence: 99%

Biomimetics of Bone Implants: The Regenerative Road

Brett

Flacco

Blackshear

et al. 2017

BioResearch Open Access

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The current strategies for healing bone defects are numerous and varied. At the core of each bone healing therapy is a biomimetic mechanism, which works to enhance bone growth. These range from porous scaffolds, bone mineral usage, collagen, and glycosaminoglycan substitutes to transplanted cell populations. Bone defects face a range of difficulty in their healing, given the composite of dense outer compact bone and blood-rich inner trabecular bone. As such, the tissue possesses a number of inherent characteristics, which may be clinically harnessed as promoters of bone healing. These include mechanical characteristics, mineral composition, native collagen content, and cellular fraction of bone. This review charts multiple biomimetic strategies to help heal bony defects in large and small osseous injury sites, with a special focus on cell transplantation.

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Hydroxyapatite-calcium sulfate-hyaluronic acid composite encapsulated with collagenase as bone substitute for alveolar bone regeneration

Cited by 116 publications

References 26 publications

Behavior of new hydroxyapatite/glucan composite in human serum

Behavior of new hydroxyapatite/glucan composite in human serum

Hyaluronic acid: a versatile biomaterial in tissue engineering

Biomimetics of Bone Implants: The Regenerative Road

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