Hydroxyapatite Formation on CaTiO&lt;SUB&gt;3&lt;/SUB&gt; Film Prepared by Metal-Organic Chemical Vapor Deposition

Sato, Mitsutaka; Tu, Rong; Goto, Takashi; Ueda, Kyosuke; Narushima, Takayuki

doi:10.2320/matertrans.mra2007016

Cited by 20 publications

(14 citation statements)

References 14 publications

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“…The preferential formation of apatite at the hollow places was also observed in CaTiO 3 film prepared by MOCVD. 12) In this study, the apatite formation rate on the HAp coatings was faster than that of -TCP coating. It is known that the elution of calcium phosphate coating must have taken place in advance of the formation of apatite.…”

Section: Apatite Formation On Ca-p-o Filmmentioning

confidence: 72%

Hydroxyapatite Formation on Ca-P-O Coating Prepared by MOCVD

Sato

Goto

et al. 2008

Mater. Trans.

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Ca-P-O coatings of -tricalcium phosphate (-TCP) and hydroxyapatite (HAp) films were prepared on commercially pure Ti (CP-Ti) by MOCVD using Ca(dpm) 2 and (C 6 H 5 O) 3 PO precursors. The behavior of apatite formation on the Ca-P-O coatings was investigated by immersing specimens in a Hanks' solution. An apatite phase has regenerated on the -TCP coating after 1 day, and has covered the whole specimen surface after 14 d. On the HAp coating, an apatite phase has regenerated after 1 h and has covered the whole surface after 6 h. The microstructure of the regenerated apatite phase on the HAp coating has changed from a needle-like to a network texture after 12 h.

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Section: Apatite Formation On Ca-p-o Filmmentioning

confidence: 72%

Hydroxyapatite Formation on Ca-P-O Coating Prepared by MOCVD

Sato

Goto

et al. 2008

Mater. Trans.

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“…It has been reported that coating with CaTiO 3 by sputtering or ion-beam-assisted deposition (IBAD) releases calcium ions in fetal bovine serum (FBS); in addition, phosphate is strongly adsorbed in experiments with CaTiO 3 powder. Furthermore, HA and/or octacalcium phosphate (OCP) formation was identified on the surface of CaTiO 3 films that were prepared by metal-organic chemical vapor deposition (MOCVD) after immersion in Hank's solution [11][12][13]. Our hypothesis is that CaTiO 3 directly coated on Ti by MOCVD could be a suitable candidate for use as a biocompatible coating for medical devices, particularly dental implants.…”

Section: Introductionmentioning

confidence: 99%

Effect of Functionally-Graded Calcium Titanate Film, Prepared by Metal-Organic Chemical Vapor Deposition, on Titanium Implant

et al. 2019

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Calcium Titanate (CaTiO3) has been introduced as an attractive biomaterial for the enhancement of calcium phosphate deposition in vivo and in vitro. We hypothesized that CaTiO3 directly coated on titanium (Ti) by metal-organic chemical vapor deposition (MOCVD) could be a suitable candidate for biocompatible coatings for medical devices, particularly dental implants. To prove this hypothesis, surface characterization, cell culture, and animal study were completed in this study. The result of this study showed that CTO 800, a CaTiO3 film prepared by heating at 800 °C, had a high hydrophilic surface. Mouse bone marrow stromal ST-2 cells cultured on substrates and CTO 800 exhibited cell differentiation, represented by alkaline phosphatase activity, compared with cells cultured on non-coated Ti and CTO 700 (a CaTiO3 film prepared by heating at 700 °C). The push-in test value of CTO 800, a parameter that indicates the degree of osseointegration, was significantly higher than that of Ti. Calcium titanate coated on Ti by MOCVD has the potential to accelerate the process of osseointegration; thus, our results support the use of CaTiO3 coating for biocompatible biomaterial for medical applications, particularly dental implants.

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“…In our previous work, we prepared calcium titanate (CaTiO 3 ), 15) -tricalcium phosphate (-Ca 3 (PO 4 ) 2 , -TCP) and hydroxyapatite (Ca 10 (PO 4 ) 6 (OH) 2 , HAp) 16) films by MOCVD and immersed them in a pseudo body fluid to investigate apatite regeneration behavior. 17,18) In the case of CaTiO 3 films, the apatite regeneration rate significantly depended on the surface morphology of films, and the nucleation of apatite occurred at hollow places on the film surface. However, in the case of -TCP and HAp films prepared by MOCVD, a smooth and dense microstructure was obtained.…”

Section: Introductionmentioning

confidence: 99%

Precipitation Behavior in a Hanks’ Solution on Ca-P-O Films Prepared by Laser CVD

Sato

Goto

et al. 2009

Mater. Trans.

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Ca-P-O films were prepared by laser CVD using Ca(dpm) 2 and (C 6 H 5 O) 3 PO metal organic precursors. The crystal phase of Ca-P-O films changed depending on deposition temperature (T dep ), total pressure (P tot ), laser power (P L ) and molar ratio of Ca to P (R Ca/P ). -TCP films in a single phase were obtained in a P-rich and high T dep region, while HAp films in a single phase were obtained in a Ca-rich and low T dep region. The -TCP films had a (220) orientation with an elongated and angular roof-shaped surface texture, whereas HAp films had a (300) orientation with a granular surface texture. Both the -TCP film and the HAp film had a dense cross section. The Ca-P-O films were immersed in a Hanks' solution for 6 h to 7 d. Particle-shaped precipitates were observed on the -TCP and HAp films after 3 d immersion. Needle-shaped precipitates covered the whole surface of HAp film after 7 d immersion.

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Hydroxyapatite Formation on CaTiO<SUB>3</SUB> Film Prepared by Metal-Organic Chemical Vapor Deposition

Cited by 20 publications

References 14 publications

Hydroxyapatite Formation on Ca-P-O Coating Prepared by MOCVD

Hydroxyapatite Formation on Ca-P-O Coating Prepared by MOCVD

Effect of Functionally-Graded Calcium Titanate Film, Prepared by Metal-Organic Chemical Vapor Deposition, on Titanium Implant

Precipitation Behavior in a Hanks’ Solution on Ca-P-O Films Prepared by Laser CVD

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Hydroxyapatite Formation on CaTiO<SUB>3</SUB> Film Prepared by Metal-Organic Chemical Vapor Deposition

Cited by 20 publications

References 14 publications

Hydroxyapatite Formation on Ca-P-O Coating Prepared by MOCVD

Hydroxyapatite Formation on Ca-P-O Coating Prepared by MOCVD

Effect of Functionally-Graded Calcium Titanate Film, Prepared by Metal-Organic Chemical Vapor Deposition, on Titanium Implant

Precipitation Behavior in a Hanks&rsquo; Solution on Ca-P-O Films Prepared by Laser CVD

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Precipitation Behavior in a Hanks’ Solution on Ca-P-O Films Prepared by Laser CVD