Hydroxyapatite from natural sources: methods and its characteristics

Afriani, Fitri; Siswoyo, Siswoyo; Amelia, Ririn; Hudatwi, Mu’alimah; Zaitun,; Tiandho, Yuant

doi:10.1088/1755-1315/599/1/012055

Cited by 11 publications

(2 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Existe la posibilidad de sintetizar hidroxiapatita a partir de una fuente natural, de un desecho como la cáscara de huevo de gallina (14)(15)(16)(17)(18)(19)teniendo en cuenta su composición rica en Calcio [20], sin embargo, aunque hay numerosos estudios en los que se ha obtenido Ha-h, hay pocos estudios documentados que hablan de la bioactividad de dicho material [21], se tienen preguntas en cuanto al comportamiento de este material en un ambiente fisiológico, de su grado de biocompatibilidad y bioactividad necesarias para aplicaciones biomédicas [22][23][24], en este caso, necesarias para determinar si es viable o no usar este material como aditivo para cementos óseos. Por lo tanto, en este trabajo se tuvo como objetivo evaluar el carácter bioactivo de muestras de HA-h para posible aplicación como cemento óseo.…”

Section: Introductionunclassified

Bioactividad de hidroxiapatita obtenida a partir de cáscara de huevo para uso potencial como cemento óseo

et al. 2022

View full text Add to dashboard Cite

Los biomateriales se han constituido como una herramienta fundamental en la ingeniería de tejidos y la medicina regenerativa, debido a que tratan y en algunos casos logran mimetizar el tejido original. Actualmente se estudian los cementos óseos como biomateriales sustitutos de hueso en diferentes patologías, y se analizan diferentes compuestos con contenido de hidroxiapatita para dotarlos de bioactividad. En el presente estudio se tuvo como objetivo evaluar el carácter bioactivo en muestras de hidroxiapatita obtenida a partir de cáscara de huevo para usarse como posible adición a los cementos óseos. La síntesis de la hidroxiapatita se realizó por el método de precipitación, en la que se usó el óxido de calcio proveniente de las cáscaras de huevo y el ácido fosfórico como fuentes de calcio y fósforo, respectivamente. La caracterización química realizada por medio de espectroscopia Raman y EDS, permitió evidenciar que se logró obtener hidroxiapatita a partir de éste residuo con una relación Ca/P de 2,187. Para el estudio de bioactividad, se sumergieron las muestras en polvo en un fluido biológico simulado durante 14 y 28 días, y con espectroscopia Raman y microscopía SEM-EDS, se caracterizaron las muestras tanto antes como después del tratamiento para determinar su relación Ca/P y comportamiento con el tiempo. Las técnicas de caracterización permitieron determinar que la hidroxiapatita de cáscara de huevo presenta propiedades bioactivas y que además es un material estable al estar en contacto con el fluido biológico simulado, una gran candidata para usarse como adición a los cementos óseos convencionales.

show abstract

Section: Introductionunclassified

Bioactividad de hidroxiapatita obtenida a partir de cáscara de huevo para uso potencial como cemento óseo

et al. 2022

View full text Add to dashboard Cite

show abstract

“…Hydroxyapatite, as a bioactive ceramic material, is the best candidate for bone tissue replacement among the variety of biomaterials [ 5 ]. Some researchers believe that the use of calcium from natural sources can reduce the risk of health issues and leads to better cell proliferation [ 6 ].…”

Section: Introductionmentioning

confidence: 99%

In Vitro Degradation and Cytotoxicity of Eggshell-Based Hydroxyapatite: A Systematic Review and Meta-Analysis

et al. 2021

View full text Add to dashboard Cite

Objective: This review focuses on the in vitro degradation of eggshell-based hydroxyapatite for analyzing the weight loss of hydroxyapatite when applied in the human body. Cytotoxicity tests were used to observe cell growth and morphological effects. A systematic review and meta-analysis were conducted to observe the weight loss and viable cells of hydroxyapatite when used for implants. Method: Based on the Population, Intervention, Comparison, and Outcome (PICO) strategy, the articles used for literature review were published in English on SCOPUS, PubMed, and Google Scholar from 1 January 2012 to 22 May 2021. Data regarding existing experiments in the literature articles the in vitro degradation and cytotoxicity testing of eggshell-based hydroxyapatite determined the biocompatibility of the materials. A meta-analysis was conducted to calculate the mean difference between the solutions and soaking times used for degradation and the stem cells used for cytotoxicity. Results: From 231 relevant studies, 71 were chosen for full-text analysis, out of which 33 articles met the inclusion criteria for degradation and cytotoxicity analysis. A manual search of the field of study resulted in three additional articles. Thus, 36 articles were included in this systematic review. Significance: The aim of this study was to highlight the importance of the biocompatibility of eggshell-based hydroxyapatite. The weight loss and viability cells of eggshell-based hydroxyapatite showed optimum results for viable cells requirements above 70%, and there is a weight loss of eggshell-based hydroxyapatite for a material implant. The meta-analysis indicated significant differences in the weight loss of eggshell-based hydroxyapatite materials with different soaking times and solutions used. The various kinds of stem cells for incubation of cultured cells in contact with a device, either directly or through diffusions with various kinds of stem cells from animals and humans, yielded viability cells above 70%.

show abstract

Hydroxyapatite synthesis and characterization from waste animal bones and natural sources for biomedical applications

Okpe,

Folorunso,

Aigbodion

et al. 2024

J Biomed Mater Res

View full text Add to dashboard Cite

Hydroxyapatites (HAps) synthesized from waste animal bones have recently gained attention due to their outstanding properties. This is because there is a need to fabricate scaffolds with desirable mechanical strength, ability to withstand high temperatures, and insoluble in solvents such as water, acetone, ethanol, and isopropyl alcohol. This study is an extensive summary of many articles on the routes of synthesis/preparation of HAp, and the optimum processing parameter, and the biomedical application areas, such as: drug administration, dental implants, bone tissue engineering, orthopedic implant coatings, and tissue regeneration/wound healing. A broad catalog of the synthesis methods (and combination methods), temperature/time, shape/size, and the calcium‐to‐phosphorous (Ca/P) value of diverse waste animal bone sources were reported. The alkaline hydrolysis method is proposed to be suitable for synthesizing HAp from natural sources due to the technique's ability to produce intrinsic HAp. The method is also preferred to the calcination method owing to the phase transformation that takes place at high temperatures during calcinations. However, calcinations aid in removing impurities and germs during heating at high temperatures. When compared to calcination technique, alkaline hydrolysis method results in crystalline HAp; the higher degree of crystallinity is disadvantageous to HAp bioactivity. In addition, the standardization and removal of impurities and contaminants, thorough biocompatibility to ensure clinical safety of the HAp to the human body, and improvement of the mechanical strength and toughness to match specific requirements for the various biomedical applications are the important areas for future studies.

show abstract

Hydroxyapatite from natural sources: methods and its characteristics

Cited by 11 publications

References 21 publications

Bioactividad de hidroxiapatita obtenida a partir de cáscara de huevo para uso potencial como cemento óseo

Bioactividad de hidroxiapatita obtenida a partir de cáscara de huevo para uso potencial como cemento óseo

In Vitro Degradation and Cytotoxicity of Eggshell-Based Hydroxyapatite: A Systematic Review and Meta-Analysis

Hydroxyapatite synthesis and characterization from waste animal bones and natural sources for biomedical applications

Contact Info

Product

Resources

About