Hydroxylapatit als biomimetischer Wirkstoff für die Remineralisation von Zahnschmelz und Dentin

Enax, Joachim; Fabritius, Helge-Otto; Meyer, Frederic

doi:10.1055/a-1167-4888

Cited by 7 publications

(7 citation statements)

References 11 publications

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“…amorphous calcium phosphate, β-tricalcium phosphate, hydroxyapatite) 31 which are not limited through regulation in their application concentrations and may even be more beneficial when toothpaste needs to be used in higher amounts. [31][32][33][34][35][36][37][38][39][40] Another argument for using higher amounts (! 0.5 g) of toothpaste is that the toothpaste is quickly diluted by saliva during tooth brushing in the oral cavity, 23 and that the brushing time to receive a good cleaning efficacy is reduced compared to smaller toothpaste amounts (►Fig.…”

Section: Discussionmentioning

confidence: 99%

Influence of the Amount of Toothpaste on Cleaning Efficacy: An In Vitro Study

et al. 2022

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Objectives The aim of this in vitro study was to test the influence of the amount of toothpaste on enamel cleaning efficacy. Materials and Methods The hydrated silica-based test toothpaste (radioactive dentin abrasion: 60.19 ± 1.35) contained all ingredients of a regular fluoride toothpaste. The cleaning efficacy of four different toothpaste amounts (1.00 g, 0.50 g [both “full length of brush”], 0.25 g [“pea-size”], and 0.125 g [“grain of rice-size”]) diluted in 1.00 mL water were each tested for different brushing times (10, 30, 60, 120, 180, and 300 seconds) using a standardized staining model on human molars with a brushing machine. Photographic documentation and colorimetric measurements were conducted, respectively, initially, after staining and after each brushing step. Colorimetric measurements were used to calculate the stain removal (in %). Statistical Analysis Results were analyzed by one-way analysis of variance with post hoc Tukey test and Levene's test for analysis of homogeneity of variance. The level of significance α was set at ≤ 0.05. Results The cleaning efficacy decreased significantly when using smaller toothpaste amounts. Stain removal after 120 seconds brushing time was: 77.4 ± 5.0% (1.00 g toothpaste), 75.7 ± 3.4% (0.50 g toothpaste), 54.1 ± 6.7% (0.25 g toothpaste), and 48.2 ± 7.1% (0.125 g toothpaste), respectively. Conclusion In this in vitro study the cleaning efficacy of a medium-abrasive, hydrated silica-based toothpaste was analyzed. Note that 1.00 g toothpaste showed for all brushing times a significantly higher cleaning efficacy than 0.25 g toothpaste and 0.125 g toothpaste.

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Section: Discussionmentioning

confidence: 99%

Influence of the Amount of Toothpaste on Cleaning Efficacy: An In Vitro Study

et al. 2022

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“…Another beneficial aspect of HA is the buffering mechanism ensured by PO 4 3− and OH − ; the ions of calcium and phosphate aid the remineralization, opposing the effect of calcium carbonate [ 50 , 51 , 52 , 53 ]. HA can influence the pH of the cariogenic biofilm, increasing it from 4.3 to 4.8.…”

Section: Hydroxyapatite For Btementioning

confidence: 99%

Bone Regeneration and Oxidative Stress: An Updated Overview

et al. 2022

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Bone tissue engineering is a complex domain that requires further investigation and benefits from data obtained over past decades. The models are increasing in complexity as they reveal new data from co-culturing and microfluidics applications. The in vitro models now focus on the 3D medium co-culturing of osteoblasts, osteoclasts, and osteocytes utilizing collagen for separation; this type of research allows for controlled medium and in-depth data analysis. Oxidative stress takes a toll on the domain, being beneficial as well as destructive. Reactive oxygen species (ROS) are molecules that influence the differentiation of osteoclasts, but over time their increasing presence can affect patients and aid the appearance of diseases such as osteoporosis. Oxidative stress can be limited by using antioxidants such as vitamin K and N‑acetyl cysteine (NAC). Scaffolds and biocompatible coatings such as hydroxyapatite and bioactive glass are required to isolate the implant, protect the zone from the metallic, ionic exchange, and enhance the bone regeneration by mimicking the composition and structure of the body, thus enhancing cell proliferation. The materials can be further functionalized with growth factors that create a better response and higher chances of success for clinical use. This review highlights the vast majority of newly obtained information regarding bone tissue engineering, such as new co-culturing models, implant coatings, scaffolds, biomolecules, and the techniques utilized to obtain them.

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“…Two studies used in situ models which generated overall remineralization conditions [10,30,31], one demineralization conditions [28], and one used an in situ model which generated overall remineralization conditions for artificial lesions and overall demineralization conditions for sound surfaces [29]. Two studies were performed in the same department, and at least one author was identical [10,31], who also cooperated in a series of research projects with employees of the firm producing one of the tested products and who also financed the studies [32]. An overview of the main characteristics of the included studies is presented in the online supplementary material Table 2.…”

Section: In Situ Studiesmentioning

confidence: 99%

Efficacy of nano-hydroxyapatite on caries prevention—a systematic review and meta-analysis

et al. 2022

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Introduction/objectives The review systematically explored in vivo or in situ studies investigating the efficacy of nano-hydroxyapatite (nHA) to reduce initiation of or to remineralize initial caries lesions. Data Prospective controlled (non-)randomized clinical trials investigating the efficacy of a nHA compared to any other (placebo) treatment or untreated/standard control. Sources Three electronic databases (Central Cochrane, PubMed-MEDLINE, Ovid EMBASE) were screened. Outcomes were, e.g., ICDAS score, laser fluorescence, enamel remineralization rate, mineral loss, and lesion depth. No language or time restrictions were applied. Risk of bias and level of evidence were graded using the Risk of Bias 2.0 tool and GRADE profiler. Study selection/results Five in vivo (and 5 in situ) studies with at least 633 teeth (1031 specimens) being assessed in more than 420 (95) patients were included. No meta-analysis could be performed for in vivo studies due to the high heterogeneity of the study designs and the variety of outcomes. In situ studies indicate that under demineralization conditions, NaF was able to hinder demineralization, whereas nHA did not; simultaneously, nHA did not differ from the fluoride-free control. In contrast, under remineralizing conditions, nHA and NaF show the same remineralizing potential. However, the level of evidence was very low. Furthermore, six studies showed a high risk of bias, and six studies were funded/published by the manufacturers of the tested products. Conclusion The low number of clinical studies, the relatively short follow-up periods, the high risks of bias, and the limiting grade of evidence do not allow for conclusive evidence on the efficacy of nHA. Clinical relevance No conclusive evidence on the efficacy of nHA could be obtained based on the low number of clinical studies, the relatively short follow-up periods, the high risks of bias, the limiting grade of evidence, and study conditions that do not reflect the everyday conditions.

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Hydroxylapatit als biomimetischer Wirkstoff für die Remineralisation von Zahnschmelz und Dentin

Cited by 7 publications

References 11 publications

Influence of the Amount of Toothpaste on Cleaning Efficacy: An In Vitro Study

Influence of the Amount of Toothpaste on Cleaning Efficacy: An In Vitro Study

Bone Regeneration and Oxidative Stress: An Updated Overview

Efficacy of nano-hydroxyapatite on caries prevention—a systematic review and meta-analysis

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