Hydroxyurea for treatment of unresectable meningiomas

Schrell, U.; Rittig, Michael; Koch, U; Marschalek, Rolf; Anders, Marc

doi:10.1016/s0140-6736(05)64757-5

Cited by 25 publications

(22 citation statements)

References 3 publications

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“…HU is used to treat hematological malignancies and also to inhibit the growth of tumor cells from other entities (Schrell et al, 1996;Bug et al, 2005;Kra¨mer et al, 2008). We found that a therapeutically achievable dose of HU (Bug et al, 2005) stalled up to 70% of MCF7 cells in S-phase without notable signs of excessive cell death.…”

Section: Resultsmentioning

confidence: 87%

Cross talk between stimulated NF-κB and the tumor suppressor p53

et al. 2010

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Nuclear factor-jB (NF-jB) and p53 critically determine cancer development and progression. Defining the cross talk between these transcription factors can expand our knowledge on molecular mechanisms of tumorigenesis. Here, we show that induction of replicational stress activates NF-jB p65 and triggers its interaction with p53 in the nucleus. Experiments with knockout cells show that p65 and p53 are both required for enhanced NF-jB activity during S-phase checkpoint activation involving ataxiatelangiectasia mutated and checkpoint kinase-1. Accordingly, the pro-inflammatory cytokine tumor necrosis factora (TNF-a) also triggers formation of a transcriptionally active complex containing nuclear p65 and p53 on jB response elements. Gene expression analyses revealed that, independent of NF-jB activation in the cytosol, TNFinduced NF-jB-directed gene expression relies on p53. Hence, p53 is unexpectedly necessary for NF-jB-mediated gene expression induced by atypical and classical stimuli. Remarkably, data from gain-and loss-of function approaches argue that anti-apoptotic NF-jB p65 activity is constitutively evoked by a p53 hot-spot mutant frequently found in tumors. Our observations suggest explanations for the outstanding question why p53 mutations rather than p53 deletions arise in tumors of various origins.

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Section: Resultsmentioning

confidence: 87%

Cross talk between stimulated NF-κB and the tumor suppressor p53

et al. 2010

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“…The risk of meningioma formation increases, and the latency period between exposure and tumor development decreases, with higher doses of radiation; however, exposure to even low radiation doses has been shown to significantly increase the risk of meningioma. 53,62,[69][70][71][72] The Israeli experience has shown that even low-dose radiation in children leads to a high and significant increase in the risk of developing meningioma. This risk should be considered when decisions are made to use radiation in routine imaging examinations, such as CT scanning, 10 or to administer higher doses of radiation for treatment of benign tumors during childhood, adolescence, and young adulthood.…”

Section: Discussionmentioning

confidence: 99%

“…Systemic treatment with tamoxifen 21 and hydroxyurea 35,[47][48][49]58,68,69 has been attempted as an adjuvant therapy in patients with recurrent, unresectable SMs. In the past, we have used both of these agents in selected RIM patients with recurrent tumors when surgery and radiotherapy failed, with no measureable response.…”

Section: Other Therapiesmentioning

confidence: 99%

Radiation-induced meningioma

Umansky¹,

Shoshan²,

Rosenthal³

et al. 2008

FOC

181

148

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✓ The long-term or delayed side effects of irradiation on neural tissue are now known to include the induction of new central nervous system neoplasms. However, during the first half of the 20th century, human neural tissue was generally considered relatively resistant to the carcinogenic and other ill effects of ionizing radiation. As a result, exposure to relatively high doses of x-rays from diagnostic examinations and therapeutic treatment was common. In the present article the authors review the literature relating to radiation-induced meningiomas (RIMs). Emphasis is placed on meningiomas resulting from childhood treatment for primary brain tumor or tinea capitis, exposure to dental x-rays, and exposure to atomic explosions in Hiroshima and Nagasaki. The incidence and natural history of RIMs following exposure to high- and low-dose radiation is presented, including latency, multiplicity, histopathological features, and recurrence rates. The authors review the typical presentation of patients with RIMs and discuss unique aspects of the surgical management of these tumors compared with sporadic meningioma, based on their clinical experience in treating these lesions.

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“…O quimioterápico hidroxiuréia administrado oralmente parece ter certo grau de resposta em adultos. Em alguns estudos, hidroxiuréia tem sido usada concomitantemente à radioterapia 22 .…”

Section: Discussionunclassified

Extenso meningioma atípico na infância: relato de caso

Rondinelli¹,

Viana

Osório³

2003

Arq. Neuro-Psiquiatr.

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RESUMO -Meningiomas são raros na criança e pequeno número de casos foi publicado até hoje. Eles são tumores tipicamente indolentes, mas, podem apresentar comportamento mais agressivo na infância. A conduta ideal é a cirurgia com ressecção completa do tumor. Na impossibilidade da remoção cirúrgica completa do tumor, as opções de tratamento são reduzidas. Nosso objetivo é descrever um caso de meningioma atípico na infância em menina de três anos, e sua evolução. PALAVRAS-CHAVE: meningioma atípico, tumores meníngeos, meningiomas na infância.A large atypical meningioma in childhood: case report ABSTRACT -Meningiomas are rare in children and a small number of cases has been published. They are tumors typically indolent, but sometimes they show an extreme aggressive behavior. The gold standard of treatment is surgery with total remove of tumor. If the surgery is not possible to do, the options of treatment are few. We describe a case of an atipical meningioma in a 3 years-old girl.KEY WORDS: atypical meningioma, tumors of the meninges, childhood meningiomas. Meningiomas são, geralmente, tumores benignos de crescimento lento. Derivam das meninges cranoespinais e são relativamente freqüentes no adulto e potencialmente curáveis com a ressecção cirúr-gica completa, pois facilmente têm um plano de clivagem entre a área tumoral e o tecido cerebral normal, que favorece a cirurgia 1 . No adulto é descrito um pico de incidência entre os 50 e os 70 anos de idade, com predomínio nas pacientes do sexo feminino 2 . A extensão da ressecção cirúrgica influencia de maneira positiva o prognóstico dos pacientes portadores de meningioma 3 . Certamente o fator mais importante no prognóstico dos meningiomas é dado pela localização e conseqüentemente pela ressecabilidade da lesão 4 . Como terapia complementar após a cirurgia, podemos citar a radioterapia, utilizada após a ressecção parcial ou completa; esta modalidade parece aumentar as possibilidades de controle local da doença 5 . A sobrevida dos meningiomas benignos situa-se ao redor de 65 a 90% em 5 anos nos adultos. Os meningiomas mais agressivos, ao contrá-rio, parecem ter prognóstico mais sombrio. Em estudo retrospectivo publicado em 1990, um total de 38 pacientes portadores de meningiomas malignos, submetidos à cirurgia e à radioterapia, apresentaram sobrevida livre de doença de 25% em 5 anos 5 . A sobrevida de 5 anos em crianças é de 76% segundo Drake e colaboradores 6 . Nosso objetivo é descrever um caso de meningioma atípico na infância precoce, a extensão da lesão, a dificuldade diagnóstica e as modalidades terapêuticas utilizadas. CASOMenina de 3 anos de idade, com história clínica com duração aproximada de 5 meses, de protusão dos globos oculares e cefaléia intermitente. Ao exame neurológico inicial, mostrava estrabismo convergente, proptose bilateral com acentuada diminuição da acuidade visual e obstrução nasal. Sem alterações reflexas e de motricidade. Ressonância magnética (RM) evidenciou extensa massa intracraniana, com intensa captação de contraste. A neoplasia compromet...

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Hydroxyurea for treatment of unresectable meningiomas

Cited by 25 publications

References 3 publications

Cross talk between stimulated NF-κB and the tumor suppressor p53

Cross talk between stimulated NF-κB and the tumor suppressor p53

Radiation-induced meningioma

Extenso meningioma atípico na infância: relato de caso

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