Hyperakusis, Phonophobie und Recruitment

Schaaf, Helmut; Klofat, Beate; Hesse, Gerhard

doi:10.1007/s00106-003-0967-y

Cited by 34 publications

(6 citation statements)

References 10 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The increase in tone-evoked responses across frequency regions after TTS might point to hyperacusis, which in humans affects all frequencies (Anari et al, 1999, Schaaf et al, 2003). Hyperacusis would likely result in decreased normalized startles as the gap carrier and noise-pulse are both well above hearing threshold.…”

Section: Discussionmentioning

confidence: 99%

“…4). Tinnitus and hyperacusis often co-occur (Anari et al, 1999, Schaaf et al, 2003, Nelson and Chen, 2004, Dauman and Bouscau-Faure, 2005). If co-occuring in the no-tinnitus group, their effects on normalized startle responses in the gap-PPI test could counteract each other, with tinnitus increasing and hyperacusis decreasing the normalized startle.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Noise Overexposure Alters Long-Term Somatosensory-Auditory Processing in the Dorsal Cochlear Nucleus—Possible Basis for Tinnitus-Related Hyperactivity?

et al. 2012

View full text Add to dashboard Cite

The dorsal cochlear nucleus (DCN) is the first neural site of bimodal auditory-somatosensory integration. Previous studies have shown that stimulation of somatosensory pathways results in immediate suppression or enhancement of subsequent acoustically-evoked discharges. In the unimpaired auditory system suppression predominates. However, damage to the auditory input pathway leads to enhancement of excitatory somatosensory inputs to the cochlear nucleus, changing their effects on DCN neurons (Zeng et al., 2009; Shore et al., 2008). Given the well described connection between the somatosensory system and tinnitus in patients we sought to determine if plastic changes in long lasting bimodal somatosensory-auditory processing accompany tinnitus. Here we demonstrate for the first time in vivo long-term effects of somatosensory inputs on acoustically-evoked discharges of DCN neurons in guinea pigs. The effects of trigeminal nucleus stimulation are compared between normal-hearing animals and animals overexposed with narrow band noise and behaviorally tested for tinnitus. The noise exposure resulted in a temporary threshold shift (TTS) in auditory brainstem responses but a persistent increase in spontaneous and sound-evoked DCN unit firing rates and increased steepness of rate-level functions (RLFs). Rate increases were especially prominent in buildup units. The long-term somatosensory enhancement of sound-evoked responses was strengthened while suppressive effects diminished in noise-exposed animals, especially those that developed tinnitus. Damage to the auditory nerve (ANF) is postulated to trigger compensatory long-term synaptic plasticity of somatosensory inputs that might be an important underlying mechanism for tinnitus generation.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Noise Overexposure Alters Long-Term Somatosensory-Auditory Processing in the Dorsal Cochlear Nucleus—Possible Basis for Tinnitus-Related Hyperactivity?

et al. 2012

View full text Add to dashboard Cite

show abstract

“…These expectations are met by the no-tinnitus group, which shows decreased normalized startles and increased absolute startles in the gap-PPI and noise pulse-PPI test. Because tinnitus and hyperacusis often co-occur (Anari et al, 1999; Schaaf et al, 2003; Nelson and Chen, 2004; Dauman and Bouscau-Faure, 2005), their effects on normalized startle responses in the gap-PPI test could counteract each other, with tinnitus increasing and hyperacusis decreasing the normalized startle values.…”

Section: Discussionmentioning

confidence: 99%

Gap prepulse inhibition and auditory brainstem-evoked potentials as objective measures for tinnitus in guinea pigs

Dehmel¹,

Eisinger²,

Shore³

2012

Front. Syst. Neurosci.

102

View full text Add to dashboard Cite

Tinnitus or ringing of the ears is a subjective phantom sensation necessitating behavioral models that objectively demonstrate the existence and quality of the tinnitus sensation. The gap detection test uses the acoustic startle response elicited by loud noise pulses and its gating or suppression by preceding sub-startling prepulses. Gaps in noise bands serve as prepulses, assuming that ongoing tinnitus masks the gap and results in impaired gap detection. This test has shown its reliability in rats, mice, and gerbils. No data exists for the guinea pig so far, although gap detection is similar across mammals and the acoustic startle response is a well-established tool in guinea pig studies of psychiatric disorders and in pharmacological studies. Here we investigated the startle behavior and prepulse inhibition (PPI) of the guinea pig and showed that guinea pigs have a reliable startle response that can be suppressed by 15 ms gaps embedded in narrow noise bands preceding the startle noise pulse. After recovery of auditory brainstem response (ABR) thresholds from a unilateral noise over-exposure centered at 7 kHz, guinea pigs showed diminished gap-induced reduction of the startle response in frequency bands between 8 and 18 kHz. This suggests the development of tinnitus in frequency regions that showed a temporary threshold shift (TTS) after noise over-exposure. Changes in discharge rate and synchrony, two neuronal correlates of tinnitus, should be reflected in altered ABR waveforms, which would be useful to objectively detect tinnitus and its localization to auditory brainstem structures. Therefore, we analyzed latencies and amplitudes of the first five ABR waves at suprathreshold sound intensities and correlated ABR abnormalities with the results of the behavioral tinnitus testing. Early ABR wave amplitudes up to N3 were increased for animals with tinnitus possibly stemming from hyperactivity and hypersynchrony underlying the tinnitus percept. Animals that did not develop tinnitus after noise exposure showed the opposite effect, a decrease in wave amplitudes for the later waves P4–P5. Changes in latencies were only observed in tinnitus animals, which showed increased latencies. Thus, tinnitus-induced changes in the discharge activity of the auditory nerve and central auditory nuclei are represented in the ABR.

show abstract

“…Bei entsprechender Veranlagung kann es beim Vorliegen einer Depression mit verstärkter Selbstbeobachtung oder bei entsprechender Veranlagung zu einer Wahrnehmungssteigerung oder Ausgestaltung kommen, die Ohrgeräusche stärker in das Bewusstsein rücken 44 . Werden in diesem Zusammenhang normale Geräusche und Wahrnehmungen als negativ und unangenehm verzerrt empfunden, ist ein Übergang zur Hyperakusis 45 oder zur Phonophobie 46 gegeben ( Tab. 4 ).…”

Section: Diskussionunclassified

Ohrgeräusche zutreffend begutachten: Möglichkeit, Plausibilität und Wahrscheinlichkeit

Michel

2021

Laryngorhinootologie

View full text Add to dashboard Cite

ZusammenfassungOhrgeräusche als subjektive, individuelle Empfindung entziehen sich einem objektiven Nachweis. In der Begutachtungssituation sind sie zudem von physiologischen oder spontanen Hörsensationen abzugrenzen.In Bezug auf die neue Königsteiner Empfehlung und auf die Rechtsprechung des letzten Jahres ist vor dem Hintergrund der unterschiedlichen Kausalitätsbegriffe in der Gesetzlichen und Privaten Unfallversicherung eine stringente Prüfung zur Feststellung, ob eine ausreichend hohe Wahrscheinlichkeit eines unfallbedingten subjektiven Ohrgeräusches vorliegt, bei der Begutachtung erforderlich. Um eine nachvollziehbare und vergleichbare Grundlage zu schaffen, wurde der Vorschlag einer Plausibilitätsprüfung mit der Erfassung von 5 Kriterien – angemessenes Ereignis, Unmittelbarkeit, Reproduzierbarkeit auf der Basis der heutigen Untersuchungsmethoden von Tinnitus-Masking und -Matching, Fortdauer und Fixierung und die Erfassung mit nichtsuggestiven Fragen – einer Überprüfung unterzogen.Die Übersichtsarbeit zeigt, dass sich die Anforderungen an den jeweiligen Beweismaßstab mit den angegebenen Nachweisschritten erfüllen lassen. Die einfache Möglichkeit des Vorliegens von Ohrgeräuschen kann über die Plausibilitätskriterien, die psychoakustische Verfahren beinhalten, sowie offene Fragen systematisch zur Wahrscheinlichkeit des Vorliegens geführt werden. Damit sind die Voraussetzungen für eine nachvollziehbare Kausalbetrachtung zwischen Ereignis und angegebenen Tinnitus nach aktuellen medizinisch-wissenschaftlichen Erkenntnissen geschaffen.

show abstract

Hyperakusis, Phonophobie und Recruitment

Cited by 34 publications

References 10 publications

Noise Overexposure Alters Long-Term Somatosensory-Auditory Processing in the Dorsal Cochlear Nucleus—Possible Basis for Tinnitus-Related Hyperactivity?

Noise Overexposure Alters Long-Term Somatosensory-Auditory Processing in the Dorsal Cochlear Nucleus—Possible Basis for Tinnitus-Related Hyperactivity?

Gap prepulse inhibition and auditory brainstem-evoked potentials as objective measures for tinnitus in guinea pigs

Ohrgeräusche zutreffend begutachten: Möglichkeit, Plausibilität und Wahrscheinlichkeit

Contact Info

Product

Resources

About