Hyperbaric Oxygen Induces Basic Fibroblast Growth Factor and Hepatocyte Growth Factor Expression, and Enhances Blood Perfusion and Muscle Regeneration in Mouse Ischemic Hind Limbs

Asano, Teita; Kaneko, Eiji; Shinozaki, Shohei; Imai, Yutaka; Shibayama, Motohide; Chiba, Tsuyoshi; Ai, Masumi; Kawakami, Akio; Asaoka, Hiroshi; Nakayama, Tôru; Mano, Yoshihiro; Shimokado, Kentaro

doi:10.1253/circj.71.405

Cited by 59 publications

(39 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A number of proangiogenic growth factors, including VEGF, are up-regulated in ischemic muscle (6,(11)(12)(13). Hypoxic conditions increase the expressions of VEGF via activation of HIF (28).…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Neuron-derived Neurotrophic Factor Functions as a Novel Modulator That Enhances Endothelial Cell Function and Revascularization Processes

Ohashi

Enomoto

Joki

et al. 2014

Journal of Biological Chemistry

View full text Add to dashboard Cite

Background: Tissue ischemia stimulates production of secreted factors that regulate angiogenesis. Results: Neuron-derived neurotrophic factor (NDNF) is up-regulated in endothelial cells in ischemic limbs of mice. NDNF stimulates endothelial cell function and promotes ischemia-induced revascularization through NOS-dependent mechanisms. Conclusion: NDNF functions as a novel modulator that stimulates revascularization processes. Significance: NDNF represents a novel therapeutic target for ischemic vascular diseases.

show abstract

Section: Discussionmentioning

confidence: 99%

“…A model of hind limb ischemia is widely used to evaluate angiogenic responses and processes (8 -10). In this model, limb ischemia leads to enhanced expression of angiogenesis-related genes (11)(12)(13).…”

mentioning

confidence: 99%

Neuron-derived Neurotrophic Factor Functions as a Novel Modulator That Enhances Endothelial Cell Function and Revascularization Processes

Ohashi

Enomoto

Joki

et al. 2014

Journal of Biological Chemistry

View full text Add to dashboard Cite

show abstract

“…Vascular regenerative therapy improves the flow of blood to ischemic tissues by inducing neovascularization in patients with vascular occlusive diseases (1)(2)(3)(4)(5)(6)(7)(8). Therapeutic methods include the direct delivery of vascular growth factors including vascular endothelial growth factor, basic fibroblast growth factor (bFGF) and hepatocyte growth factor, the delivery of genes into host cells for the on-site production of vascular growth factors and the direct delivery of somatic stem cells capable of generating new vessels (9)(10)(11)(12)(13).…”

Section: Introductionmentioning

confidence: 99%

Vascular regeneration by pinpoint delivery of growth factors using a microcatheter reservoir system in a rabbit hind-limb ischemia model

Nitta

Nitta-Seko

Sonoda

et al. 2012

Experimental and Therapeutic Medicine

View full text Add to dashboard Cite

Abstract. The purpose of this study was to compare the results of delivering low doses of growth factor iteratively (20 µg x5) via a reservoir system with results obtained following a single administration of 100 µg of growth factor. The delivery systems using gelatin microspheres (GMS) facilitate the controlled release of drugs. The controlled release of growth factors at specific sites is essential for vascular regeneration. An ischemic hind-limb model was established in nine rabbits. A reservoir system was implanted in each rabbit. GMS impregnated with basic fibroblast growth factor (bFGF) through an indwelling 2-Fr catheter was infused in the reservoir system. The rabbits were divided into three equal groups: group 1 received 20 µg iteratively (x5) via the reservoir, a single dose of 100 µg growth factor was administered to group 2 and group 3 was the saline control. The therapeutic effects were evaluated by measuring the thigh temperature, blood pressure and blood flow. An immunohistological analysis was also performed for CD31. No significant difference was observed between preand post-treatment (4 weeks following bFGF infusion) in the thigh temperature, blood pressure and blood flow results from each group. Pathological analysis revealed that the number of regenerated vessels was significantly higher in the group treated iteratively with low-dose bFGF.

show abstract

“…The angiogenic action of HBO therapy has been observed previously (34,35). Increased VEGF-β production by HBO treatment was observed in a wound model, whereas induction of b-FGF and HGF without affecting VEGF was found in the ischemic hind limbs (36). Despite the increased expression of b-FGF and VEGF-β, the high proteolytic activity in this environment results in their degradation (30).…”

Section: Discussionmentioning

confidence: 54%

α-Lipoic Acid Modulates Extracellular Matrix and Angiogenesis Gene Expression in Non-Healing Wounds Treated with Hyperbaric Oxygen Therapy

Alleva

Tomasetti²,

Emanuelli

et al. 2008

Mol Med

View full text Add to dashboard Cite

α-Lipoic acid (LA) has been found previously to accelerate wound repair in patients affected by chronic wounds who underwent hyperbaric oxygen (HBO) therapy. Because proteinases are important in wound repair, we hypothesized that LA may regulate matrix metalloproteinase (MMP) expression in cells that are involved in wound repair. Patients undergoing HBO therapy were double-blind randomized into two groups: the LA group and the placebo group. Gene expression profiles for MMPs and for angiogenesis mediators were evaluated in biopsies collected at the first HBO session, at the seventh HBO session, and after 14 days of HBO treatment. ELISA tests were used to validate microarray expression of selected genes. LA supplementation in combination with HBO therapy downregulated the inflammatory cytokines and the growth factors which, in turn, affect MMPs expression. The disruption of the positive autocrine feedback loops that maintain the chronic wound state promotes progression of the healing process.

show abstract

Hyperbaric Oxygen Induces Basic Fibroblast Growth Factor and Hepatocyte Growth Factor Expression, and Enhances Blood Perfusion and Muscle Regeneration in Mouse Ischemic Hind Limbs

Cited by 59 publications

References 29 publications

Neuron-derived Neurotrophic Factor Functions as a Novel Modulator That Enhances Endothelial Cell Function and Revascularization Processes

Neuron-derived Neurotrophic Factor Functions as a Novel Modulator That Enhances Endothelial Cell Function and Revascularization Processes

Vascular regeneration by pinpoint delivery of growth factors using a microcatheter reservoir system in a rabbit hind-limb ischemia model

α-Lipoic Acid Modulates Extracellular Matrix and Angiogenesis Gene Expression in Non-Healing Wounds Treated with Hyperbaric Oxygen Therapy

Contact Info

Product

Resources

About