Hyperbaric oxygen should be used for carbon monoxide poisoning

Sethuraman, Kinjal N.; Thom, Stephen R.

doi:10.1111/bcp.15605

Cited by 5 publications

(3 citation statements)

References 38 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In Deutschland erfolgt die Behandlung auf der Grundlage empirischer Daten innerhalb von 24 h typischerweise mit 3 Therapiesitzungen, beginnend mit dem Boerema-Schema mit einem Behandlungsdruck von 3 bar über 90 min, gefolgt von 2 weiteren Therapiesitzungen bei mindestens 2,4 bar Behandlungsdruck. Da bestimmte antiinflammatorische Prozesse erst ab einem Behandlungsdruck von > 2,5 bar wirksam in Gang gesetzt werden, erscheint die Verwendung von Schemata mit höheren Behandlungsdrücken zur Verbesserung des Outcomes sinnvoller [18]. Unter Umständen hat dies auch Einfluss auf die Anzahl der notwendigen Therapiesitzungen.…”

Section: Durchführungunclassified

Kohlenmonoxidintoxikation

Fichtner,

Staak

2024

Notfallmedizin up2date

View full text Add to dashboard Cite

Section: Durchführungunclassified

Kohlenmonoxidintoxikation

Fichtner,

Staak

2024

Notfallmedizin up2date

View full text Add to dashboard Cite

“…It is widely used in the treatment of spinal cord injury, traumatic brain injury sequelae, carbon monoxide poisoning and other nerve injury diseases. [18][19][20] Current studies mainly focus on the effectiveness of HBO by improving oxygen partial pressure, reducing brain edema, reducing inflammatory factors, clearing free radicals, anti-apoptosis and anticholinergic effects. 21 The effect and mechanism of HBO on cognitive decline and hippocampal dysfunction are not fully understood.…”

Section: Efficacy Analysis Of Hbo In the Treatment Of Amcimentioning

confidence: 99%

Hyperbaric Oxygen Improves Long-Term Learning and Memory Impairment by Attenuating Neuronal Apoptosis in aMCI Rats

Zhang,

Lin,

et al. 2024

JIR

View full text Add to dashboard Cite

Background With the aging of the population and the increasing incidence of neurological diseases, amnestic mild cognitive impairment (aMCI) has attracted attention. Hyperbaric oxygen (HBO) has gradually shown the potential in the treatment of aMCI as an emerging treatment method in recent times. This study is to observe the effect of HBO on the long-term learning memory of aMCI rats, and investigate the associated mechanisms. Methods Seventy-two male rats (4-month-old) were randomly divided into control (CON) group, aMCI group, HBO group, 24 rats in each group. Each group was randomly divided into CON 1 , CON 7 , CON 28 ; aMCI 1 , aMCI 7 , aMCI 28 ; HBO 1 , HBO 7 , HBO 28 , 8 rats in each group. The aMCI model rats were established in aMCI and HBO groups. HBO group was treated with HBO for 7 days. The ethological and cytopathology which include Morris water maze (MWM) test, HE staining, TUNEL staining and the expression of Fas/FasL on neuron membrane were conducted to evaluate the effects of HBO on day 1, day 7 and day 28 after HBO treatment. Results MWM test showed that the spatial learning and memory ability of the rats decreased in aMCI group, and recovered in HBO group; Compared with aMCI group, the pathological damage of hippocampal nerve cells was alleviated, the number of apoptotic cells was significantly reduced (P < 0.05), and the expression of Fas/FasL on the surface of nerve cell membrane was significantly weakened in HBO group (P < 0.05). There were no significant changes in the spatial learning and memory ability, pathological damage of hippocampal neurons, the number of apoptotic cells, and the changes of Fas/FasL on the surface of hippocampal neurons in HBO 1 , HBO 7 , and HBO 28 groups (P > 0.05). However, in aMCI 1, aMCI 7 , and aMCI 28 groups gradually aggravated (P < 0.05). Conclusion 1. HBO can improve the long-term learning and memory impairment by attenuating neuronal apoptosis in aMCI rats. 2. Fas/FasL mediated cell receptor death pathway is involved in the apoptosis of hippocampal neurons.

show abstract

“…cognitive, vestibular and motor impairments occur in ~25-50% of survivors from severe poisoning [12]. Sethuraman and Thom presented that HBOT at a dose of 2.5-3.0 atmospheres absolute (ATA) is a necessary treatment for acute CO poisoning with appropriate consideration for pathology and therapeutic mechanisms [13].…”

Section: Introductionmentioning

confidence: 99%

Safety Evaluation of Monoplace Hyperbaric Chamber and Clinical Characteristics of Hyperbaric Oxygen Therapy for Patients with Carbon Monoxide Poisoning

LEE,

KIM,

LEE

et al. 2024

Preprint

View full text Add to dashboard Cite

Hyperbaric oxygen therapy (HBOT) is a well-established treatment for carbon monoxide (CO) poisoning. HBOT is performed in a hyperbaric chamber, which increases the atmosphere absolute (ATA) and oxygen concentration in the chamber. To ensure patient safety during HBOT, a gas monitoring system is used to monitor the oxygen levels, ATA, and other parameters. This study aims to perform the safety evaluation of the monoplace hyperbaric chamber compared to a gas monitoring system in the treatment of CO poisoning. In addition, it examined the clinical characteristics of the patients diagnosed with CO poisoning who performed HBOT. In the safety evaluation of the monoplace chamber, it was compared the values of oxygen (O2), carbon dioxide (CO2), humidity, and temperature were measured in the hyperbaric chamber and gas monitoring system when operating at 2.0 ATA and 3.0 ATA. Moreover, in the clinical characteristics of patients with CO poisoning who performed HBOT, 1,006 patients were analyzed by using the data registry. Under the condition at 3.0 ATA, the average CO2 was higher in the hyperbaric chamber than in the gas monitoring system (p&lt;0.001). Also, the average humidity was higher in the hyperbaric chamber than in the gas monitoring system (p=0.004). Under the condition at 2.0 ATA, the average humidity was higher in the hyperbaric chamber than in the gas monitoring system (p&lt;0.001). Also, the average temperature was lower in the hyperbaric chamber than in the gas monitoring system (p&lt;0.001). The mean age of the 1,006 CO poisoning patients who received HBOT was 44.93±19.78 years. According to the source of CO, 680 patients (67.6%) visited ER most commonly due to charcoal. The median maximal CO exposure time and time from rescue to ER were 4.0 hours and 3.09 hours, respectively. The median GCS score at the scene or ER was 15. According to the underlying comorbidities, psychiatric diseases (19.5%) were the most common, followed by hypertension (18.1%) and diabetes mellitus (11.5%). In the emergency room, some patients had appeared symptoms such as loss of consciousness (59.8%), shock (6.7%), or seizure (8.3%). The results of this study could be expected that HBOT can be effectively performed by monitoring the gas concentration change inside the hyperbaric chamber.

show abstract

Hyperbaric oxygen should be used for carbon monoxide poisoning

Cited by 5 publications

References 38 publications

Kohlenmonoxidintoxikation

Kohlenmonoxidintoxikation

Hyperbaric Oxygen Improves Long-Term Learning and Memory Impairment by Attenuating Neuronal Apoptosis in aMCI Rats

Safety Evaluation of Monoplace Hyperbaric Chamber and Clinical Characteristics of Hyperbaric Oxygen Therapy for Patients with Carbon Monoxide Poisoning

Contact Info

Product

Resources

About