Hyperbaric oxygen therapy for chronic radiation-induced tissue injuries: Australasia's largest study

Tahir, Abdul Rahim Mohd; Westhuyzen, Justin; Dass, Joshua; Collins, Michael; Webb, R. K.; Hewitt, Susan; Fon, P.J.; McKay, Michael J.

doi:10.1111/ajco.12289

Cited by 55 publications

(51 citation statements)

References 32 publications

(76 reference statements)

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“…Summarizing all included studies, the overall response rate varied between 64.8% and 100.0% (86.4% weighted average across the studies) in studies that provided this overall response value . The CR rate varied between 20.0% and 100.0% (63.6% weighted average) .…”

Section: Resultsmentioning

confidence: 99%

“…In the included studies, however, dental pain (due to sinus barotrauma) and vision disorder (due to eye barotrauma) were exceedingly rare, whereas otalgia (due to ear barotrauma) was more frequently reported in the included studies, and in one study even affected one‐third of the patients . It is of note that the majority of these cases include fully reversible ear barotrauma, in up to just 5% requiring myringotomy . Overall, HBOT can therefore be considered as an effective and safe treatment.…”

Section: Discussionmentioning

confidence: 97%

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Hyperbaric oxygen therapy for radiation cystitis after pelvic radiotherapy: Systematic review of the recent literature

et al. 2019

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The present study assessed the efficacy of hyperbaric oxygen therapy in reducing symptoms of radiation cystitis, a specific type of iatrogenic injury to the bladder, by systematic review of recent literature. The MEDLINE, Embase and Web of Science databases were searched using combinations of the terms “radiation,” “cystitis” and “hyperbaric oxygen” to identify articles evaluating patients with radiation cystitis, treated with hyperbaric oxygen therapy. Only recent (≤10 years) original studies were included. Data were extracted and pooled in order to calculate descriptive weighted averages. Articles were evaluated on their level of evidence. A total of 20 papers were obtained, resulting in a cohort of 815 patients who were treated with hyperbaric oxygen therapy for radiation cystitis. Overall and complete response rates varied from 64.8% to 100% and 20% to 100%, respectively. The weighted average overall and complete response rates were 87.3% and 65.3%, respectively. Adverse events were observed in 9.6% of the patients, but permanent side‐effects were rare. The most prominent limitations were high cost and low availability. Hyperbaric oxygen therapy is effective in the treatment of radiation‐induced cystitis, with minimal adverse events, but low availability and high cost. At present, evidence is low; therefore, more prospective studies are required.

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Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 97%

Hyperbaric oxygen therapy for radiation cystitis after pelvic radiotherapy: Systematic review of the recent literature

et al. 2019

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“…In one large Australian study, 64% of patients receiving HBOT for LSTRI who incidentally suffered xerostomia reported improvement in symptoms . Cankar et al .…”

Section: Discussionmentioning

confidence: 99%

Hyperbaric oxygen treatment for the management of radiation‐induced xerostomia

2018

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“…Nonetheless, many prospective studies [64][65][66] and retrospective studies [63][64][65][66][67][68][69][70][71][72][73][74][75][76][77][78] have been performed, and the results are presented in Table 3. Results are consistent and show a generally good response rate (80 %) especially in case of a short delay between the onset of bleeding and the initiation of HBO therapy (B6 months) [70,75].…”

Section: Hyperbaric Oxygen Therapymentioning

confidence: 99%

A Practical Approach to the Management of Radiation-Induced Hemorrhagic Cystitis

Liem

Saad

Delouya

2015

Drugs

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Radiation-induced hemorrhagic cystitis (HC) is a complication of pelvic radiotherapy, mainly for prostate and uterine cancers. In the acute phase, patients feel urinary urgency and bladder pain. This phase is reversible after radiotherapy. In the chronic stage, an irritative syndrome is coupled with hematuria during the 2-10 years following radiotherapy. Cystoscopy shows white and frosted mucosa with telangiectasia. The incidence is estimated at 5 % or less. It is suggested that the radiation oncologist reviews the dosimetry plan to validate that the lesions coincide with significant radiation exposure confirming diagnosis of radiation-induced HC. The treatment for HC is first symptomatic, with bladder lavage, clot evacuation, coagulation via cystoscopy and blood transfusions if necessary. Subsequently, hyaluronic acid bladder instillation can be done with little toxicity. Hyperbaric oxygen therapy delivers pure oxygen to patients in a pressurized cabin, promoting angio-neogenesis and lowering hypoxia to the irradiated tissues. The clinical response rate is estimated to be around 80 %. Nevertheless, this approach is limited by the low availability, and length of treatment. While surgery remains an effective treatment for HC, it is the last option because of the high morbidity and mortality risks. Prospective studies need to be conducted to identify and evaluate new interventions, particularly for HC.

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Hyperbaric oxygen therapy for chronic radiation-induced tissue injuries: Australasia's largest study

Abstract: Our study demonstrates that hyperbaric oxygen therapy can be effectively used in a variety of chronic radiation-induced tissue injuries; its favorable risk profile suggests it should be considered for patients with radiation-induced tissue injuries.

Cited by 55 publications

References 32 publications

Hyperbaric oxygen therapy for radiation cystitis after pelvic radiotherapy: Systematic review of the recent literature

Hyperbaric oxygen therapy for radiation cystitis after pelvic radiotherapy: Systematic review of the recent literature

Hyperbaric oxygen treatment for the management of radiation‐induced xerostomia

A Practical Approach to the Management of Radiation-Induced Hemorrhagic Cystitis

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