Hypercalcemia as a result of sarcoidosis with normal serum concentrations of vitamin D

Falk, Sandor; Kratzsch, J.; Paschke, Ralf; Stumvoll, M; Koch, Christin

doi:10.1055/s-2005-862990

Cited by 19 publications

(29 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Furthermore, vitamin D status and 1,25 (OH) 2 D 3 have been suggested to be protective against tuberculosis (TB) where host immunity depends on Th1 production of the cytokine IFN-γ. Clouding the picture further is the evidence that patients with Th1 driven diseases like IBD (Crohn's disease), sarcoidosis and tuberculosis show hypercalcemia and calcification of granulomatous lesions and suggest that the local immune response may produce 1,25(OH) 2 D 3 (Yang et al 2000;Tuohy et al 2005;Volpicelli et al 2005;Falk et al 2007). How can 1,25(OH) 2 D 3 selectively regulate the immune system Phone: 814-863-2819, Fax: 814-863-6140, E-mail address: mxc69@psu.edu.…”

Section: Introductionmentioning

confidence: 99%

The paradoxical effects of vitamin D on type 1 mediated immunity

Cantorna

Bruce

2008

Molecular Aspects of Medicine

123

115

View full text Add to dashboard Cite

Low vitamin D status is associated with an increased risk of Th1 mediated autoimmune diseases like inflammatory bowel disease. 1,25(OH) 2 D 3 treatments have been shown to suppress Th1 mediated immunity and protect animals from experimental autoimmunity. Th1 mediated immunity is important for clearance of a number of different infectious diseases. For tuberculosis 1,25(OH) 2 D 3 treatment is associated with decreased Th1 mediated immunity but increased bactericidal activity. Systemic candidiasis is unaffected by 1,25(OH) 2 D 3 treatment. The seemingly paradoxical effects of 1,25(OH) 2 D 3 and vitamin D on Th1 mediated autoimmunity versus infectious immunity point to a broad array of vitamin D targets in the immune system. The interplay of these vitamin D targets and their impact on the host-immune response then dictate the outcome.

show abstract

Section: Introductionmentioning

confidence: 99%

The paradoxical effects of vitamin D on type 1 mediated immunity

Cantorna

Bruce

2008

Molecular Aspects of Medicine

123

115

View full text Add to dashboard Cite

show abstract

“…Дру-гие авторы [16] считают, что внепочечная гиперпро-дукция 1,25(ОН) 2 D потенциируется цитокинами (в частности, γ-интерфероном) и повышенный уро-вень 1,25(ОН) 2 D отражает хроническое течение сар-коидоза. Описаны также случаи гиперкальциемии при саркоидозе на фоне нормального уровня 1,25(ОН) 2 D и повышенной концентрации PTHrP [3,10,17].…”

Section: Discussionunclassified

“…Считается, что основной причиной гипрекальцие-мии при саркоидозе является повышенная экспрес-сия макрофагами 1α-гидроксилазы, ответственного за гидроксилирование of 25-OH D с превращением его в активную форму 1,25(OH) 2 D [8,9]. Гиперпро-дукция 1,25(OH) 2 гиперкальциемии у больных саркоидозом описаны и при нормальном уровне 1,25(OH) 2 D в крови при гиперпродукции PTHrP, а также при сопутствую-щей аденоме паращитовидной железы [3,7,10].…”

unclassified

Difficulties of differential diagnostics of primary hyperparathyroidism and sarcoidosis of cervical lymph nodes

Severskaya

Северская²,

Semin

et al. 2015

Probl Endokrinol (Mosk)

View full text Add to dashboard Cite

A case of isolated sarcoidosis of cervical lymph nodes is reported that was first erroneously interpreted as parathyroid adenoma. The patient was a 70 year-old woman presenting with hypercalcemia and elevated blood parathormone level. The ultrasound study showed the presence of a tissue mass measuring 1.5 cm in the projection of the inferior right parathyroid gland. The scintigraphic study with 99mTc MIBI demonstrated the accumulation of the radiopharmacological agent in the tissue mass that was identified as an adenoma of the parathyroid gland. The surgical removal of this neoplasm together with the adjacent lymph nodes resulted in the normalization of the blood calcium and parathormone levels. The histological study revealed sarcoidosis of lymph nodes in the absence of lesions in other organs. A literature review of the problem pertaining to hypercalcemia associated with sarcoidosis of cervical lymph nodes is presented with special reference to the difficulties encountered in differential diagnostics of this condition.

show abstract

“…Eine Hyperkalzämie mit normalen 1,25-Vitamin-D3-Spiegeln ist selten, aber ebenfalls beschrieben [5,7]. Über einige dieser Patienten wurde ausführlich berichtet [4,6]. Neben bisher unklarem Pathomechanismen muss für eine Hyperkalzämie mit normalem 1,25-Vita min-D3-Spiegel und supprimiertem Parathormon auch eine erhebliche enterale Kalziumzufuhr diskutiert werden.…”

Section: Nierenbiopsieunclassified