Hyperglycemia and duration of diabetes as risk factors for abnormal lipids: a cross sectional survey of 19,757 patients with type 2 diabetes in China

Ji, Linong; Weng, Jianping; Lu, Juming; X, Guo; Yang, Wenying; Jia, Weiping; Zou, Da-jin; Zhou, Zhiguang; Zhu, Dalong; Ji, Qiuhe; Shi, Lixin; Yang, Xilin

doi:10.1007/s40618-014-0115-4

Cited by 7 publications

(8 citation statements)

References 31 publications

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“…However, the prevalence of low HDL-C increased at first and then declined along with increasing HbA1c, with the lowest prevalence being observed among the 11%≤HbA1c<13% group. A similar trend of lipid distribution was found in the China lipid study, with highest prevalence of low HDL-C among the HbA1c 8% group [11].…”

Section: Discussionsupporting

confidence: 81%

“…Dyslipidemia interacts with glucose metabolism. One previous study have reported that HbA1c was associated with low HDL cholesterol in a J-shaped manner, and hyperglycemia defined as HbA1c≥7.0 % increased risk of high LDL cholesterol in T2DM [11]. Although compared with HbA1c<7% ,T2DM patients with HbA1c≥7% had significantly higher levels of lipid profile [12,13], it is unknown whether there was a linear and significant increase levels of lipid profile associated with HbA1c value of ≥7%.…”

Section: Introductionmentioning

confidence: 99%

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Dyslipidemia in Type 2 Diabetes Mellitus Patients With Poor Glycemic Control: Relationship Between HbA1c and Lipid Profile.

Xu¹,

Qiu²,

Yuan³

et al. 2021

Preprint

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Aims: This study identified the lipid profile across a full range of poor glycemic control and the association between lipid profiles with different specific glycated hemoglobin (HbA1c) cutoffs in patients with type 2 diabetes (T2DM). Methods: A total of 1183 T2DM patients with poor glycemic control (HbA1c>7%) selected through convenience sampling in three hospitals of Jiangsu province were surveyed during April 2018 and July 2019. Dyslipidemia was defined according to criteria of the Third Report of the National Cholesterol Education Program Adult Treatment Panel III (NCEP ATP III).Results: The prevalence of dyslipidemia was 55.2 % overall. Of 1183 subjects, 13.0% had high total cholesterol (TC), 33.1% had low high density lipoprotein cholesterol (HDL-C), 9.9% had high low density lipoprotein cholesterol (LDL-C), and 28.4% had high triglycerides (TG) concentrations. There was an increase in frequency of dyslipidemia in patients with different cutoff values of HbA1c (P<0.05). The prevalence of high TC was closely related with different cutoff values of HbA1c (adjusted OR =1.77, 2.56 3.82, respectively). Patients with HbA1c values 9%≤HbA1c<11% and HbA1c≥13% had significantly higher prevalence of dyslipidemia compared with the patients who had 7≤HbA1c<9%.Conclusion: T2DM patients with 9%≤HbA1c<11% and HbA1c≥13% tend to have moderate and severe dyslipidemia respectively, suggesting the importance of glycemic control in normalizing dyslipidemia.

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Section: Discussionsupporting

confidence: 81%

Section: Introductionmentioning

confidence: 99%

Dyslipidemia in Type 2 Diabetes Mellitus Patients With Poor Glycemic Control: Relationship Between HbA1c and Lipid Profile.

Xu¹,

Qiu²,

Yuan³

et al. 2021

Preprint

View full text Add to dashboard Cite

show abstract

“…However, the prevalence of low HDL-C increased at rst and then declined along with advancing HbA1c, with the lowest prevalence being observed among the 11%≤HbA1c<13% group. A similar trend of lipid distribution was found in the China lipid study, with highest prevalence of low HDL-C among the HbA1c 8% group [11].…”

Section: Discussionsupporting

confidence: 81%

Dyslipidemia in Type 2 Diabetes Mellitus With Poor Glycemic Control: Prevalence, Associated Factors, and Relationship Between HbA1c and Lipid Profile.

Li¹,

Xu²,

Qiu³

et al. 2020

Preprint

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BackgroundCcompared with HbA1c<7% ,T2DM patients with HbA1c≥7% had significantly higher levels of lipid profile, however, it is unknown whether there was a linear and significant increase levels of lipid profile associated with HbA1c value of ≥7%. This study identified the lipid profile across a full range of poor glycemic control and the association between lipid profiles with different specific HbA1c cutoffs.MethodsA total of 1183 type 2 diabetes patients with poor glycemic control (HbA1c>7%) selected through convenience sampling in three hospitals of Jiangsu province were surveyed. Dyslipidemia was defined according to criteria of the Third Report of the National Cholesterol Education Program Adult Treatment Panel III (NCEP ATP III). ResultsThe prevalence of dyslipidemia was 55.2 % overall. Of 1183 subjects, 13.0% had high TC, 33.1% had low HDL-C, 9.9% had high LDL-C, and 28.4% had high TG concentrations. There was an increase in frequency of dyslipidemia in patients with different cutoff values of HbA1c (P<0.05).The prevalence of high TC was closely related with different cutoff values of HbA1c (adjusted OR =1.77, 2.56 3.82, respectively). Patients with HbA1c values 9%≤HbA1c<11% and HbA1c≥13% had significantly higher prevalence of dyslipidemia compared with the patients who had 7≤HbA1c<9%.ConclusionDiabetic patients with 9%≤HbA1c<11% and HbA1c≥13% tend to have moderate and severe dyslipidemia respectively and suggest the importance of glycemic control in normalizing dyslipidemia.

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“…Although the associations between hyperlipidemia and hyperglycemia were extensively covered in observational studies 9–11 , the causal relationship for them is still indeterminate. A recent MR-analysis taking common 10 TG-associated SNPs as IV did not support the causal role of TG for increased fasting glucose 39 .…”

Section: Discussionmentioning

confidence: 99%

“…Among which, the elevated TG 4–6 and LDL-C 7,8 have been affirmatively proved as causal factors for coronary heart disease (CHD). On the other hand, HbA1c was extensively reported to be associated with the circulating lipid profile 9–11 . Lately, a trajectory analysis on youths with type 1 diabetes demonstrated that elevation of HbA1c from childhood into young adulthood may result in increases in LDL and non-HDL cholesterols 12 .…”

Section: Introductionmentioning

confidence: 99%

Mendelian Randomization Analysis Support Causal Associations of HbA1c with Circulating Triglyceride, Total and Low-density Lipoprotein Cholesterol in a Chinese Population

Hou

Zhao

et al. 2019

Sci Rep

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Previous observational studies supported a positive association of glycated hemoglobin A1c (HbA1c) level with serum triglyceride (TG), total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), and high-density lipoprotein cholesterol (HDL-C). However, the causal relationship between HbA1c and either one of them was unclear in the East Asians. We performed a Mendelian Randomization (MR) analysis in a community-based study sample in Shanghai, China (n = 11,935). To clarify the cause-and-effect relationships of HbA1c with the four interested lipids, an Expanded HbA1c genetic risk score (GRS) with 17 HbA1c-related common variants and a Conservative score by excluding 11 variants were built and adopted as the Instrumental Variables (IVs), respectively. The Expanded HbA1c-GRS was associated with 0.19 unit increment in log-TG ( P = 0.009), 0.42 mmol/L TC ( P = 0.01), and 0.33 mmol/L LDL-C ( P = 0.01); while the Conservative HbA1c-GRS was associated with 0.22 unit in log-TG ( P = 0.03), 0.60 mmol/L TC ( P = 0.01), and 0.51 mmol/L LDL-C ( P = 0.007). No causal relationship was detected for HDL-C. Sensitivity analysis supported the above findings. In conclusions, MR analysis supports a causal role of increased HbA1c level in increment of circulating TG, TC, and LDL-C in a Chinese population.

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Hyperglycemia and duration of diabetes as risk factors for abnormal lipids: a cross sectional survey of 19,757 patients with type 2 diabetes in China

Abstract: Hyperglycemia defined as HbA1c ≥7.0 % increased risk of high LDL cholesterol in T2D.

Cited by 7 publications

References 31 publications

Dyslipidemia in Type 2 Diabetes Mellitus Patients With Poor Glycemic Control: Relationship Between HbA1c and Lipid Profile.

Dyslipidemia in Type 2 Diabetes Mellitus Patients With Poor Glycemic Control: Relationship Between HbA1c and Lipid Profile.

Dyslipidemia in Type 2 Diabetes Mellitus With Poor Glycemic Control: Prevalence, Associated Factors, and Relationship Between HbA1c and Lipid Profile.

Mendelian Randomization Analysis Support Causal Associations of HbA1c with Circulating Triglyceride, Total and Low-density Lipoprotein Cholesterol in a Chinese Population

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