Hyperhomocysteinia is a risk factor for retinal venous occlusion: A case control study

Wadani, Fahad Al; Khandekar, Rajiv; Salim, Gigani; Ali, Mohammed Al; Ramzi, Salman

doi:10.4103/0301-4738.111213

Cited by 8 publications

(4 citation statements)

References 29 publications

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“…Similarly many studies with age and sex matched of participants evaluating the homocysteine levels in patients of retinal vein occlusion were conducted. [19][20][21] Like in our study incidence of RVO increases with advancing age.…”

Section: Discussionsupporting

confidence: 77%

A study of serum homocysteine and serum vitamin B12 levels in patients with retinal vein occlusion and its correlation

Toshniwal¹,

Lune²,

Paranjpe³

et al. 2020

IJCEO

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To find out the association of serum homocysteine levels and serum vitamin B-12 levels in patients with retinal vein occlusion.Patients of all age group and any sex who are coming in vitreoretinal OPD of department of ophthalmology at a tertiary care hospital of Western Maharashtra were studied. 50 cases of RVO and same number of age and sex matched controls were taken into consideration. All patients were underwent for assay of serum homocysteine by ECLIA method and serum Vitamin B12 by CMIA method.The highest number of cases were of BRVO (60%) followed by CRVO (30%) and only one case of TVO (2%) was noted. The average level of homocysteine in RVO and control group is found to be 23.80 and 12.43 whereas the standard deviation of homocysteine level in RVO group is 13.28 and control group is 10.58. Therefore levels of homocysteine are significantly higher in RVO group in comparison with control group. Vitamin B-12 level was 455.86 in control group and 325.8 in RVO group. The P value suggests that, Vitamin B12 was significantly lower in case group compared to controls. Vitamin B-12 levels were significantly lower in cases with a higher Homocysteine level. Hype-rhomocysteinemia and hypovitaminosis B12 is significantly present in cases of retinal vein occlusion irrespective of types and underlying systemic diseases.

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Section: Discussionsupporting

confidence: 77%

A study of serum homocysteine and serum vitamin B12 levels in patients with retinal vein occlusion and its correlation

Toshniwal¹,

Lune²,

Paranjpe³

et al. 2020

IJCEO

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“…also reported hyperhomocysteinemia as a risk factor for RVO. [ 14 ] However, there was no evidence to suggest an association between homozygosity for the MTHFR C677T genotype and RVO. [ 5 14 ] Similarly, in our study, we did not observe any association of MTHFR gene mutation and RVO.…”

Section: Discussionmentioning

confidence: 99%

“…[ 14 ] However, there was no evidence to suggest an association between homozygosity for the MTHFR C677T genotype and RVO. [ 5 14 ] Similarly, in our study, we did not observe any association of MTHFR gene mutation and RVO. Therefore, we hypothesize that MRHFR C677T mutation is associated with higher serum homocysteine level but is not at the same time associated with RVO occurrence which can be due to still unknown factor which subsequently leads to a protective effect on RVO.…”

Section: Discussionmentioning

confidence: 99%

Investigation of methylenetetrahydrofolate reductase C677T and factor V Leiden mutation as a genetic marker for retinal vein occlusion

Nema

Verma

Kumar

2018

Taiwan J Ophthalmol

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PURPOSE:Thromboembolic phenomenon is one of the causes of retinal vein occlusion (RVO) which is in fact a multifactorial disease. Therefore, we aimed to study methylenetetrahydrofolate reductase gene polymorphism (MTHFR C677T) and factor V Leiden as genetic risk factors of RVO.MATERIALS AND METHODS:A total of 50 (19 males and 31 females) cases of RVO were compared with 50 age- and sex-matched (21 males and 29 females) controls. Complete ocular examination was done for all samples. The diagnosis of RVO was made clinically; however, fundus fluorescein angiography and optical coherence tomography were performed when needed. Serum homocysteine levels were estimated by automatic chemiluminescence analyzer, whereas MTHFR C677T and factor V Leiden mutations were detected by polymerase chain reaction–restriction fragment length polymorphism method.RESULTS:The mean age of RVO cases and controls was 54.62 ± 13.92 years and 58.72 ± 11.20 years, respectively. 48.3% of cases and 51.7% of controls were diabetic. 65.3% of cases were hypertensive proving hypertension as a strong risk factor (P = 0.003) of RVO. Serum homocysteine was also found significantly high (P = 0.025) with mean values of 19.98 ± 9.03 μmol/L and 16.98 ± 8.29 μmol/L in cases and controls, respectively. The MTHFR genotype (CT) was found in 83.3% patients of central RVO group and 78.6% cases of branch RVO group that was significantly associated with high serum homocysteine levels. Factor V Leiden mutation was absent in all individuals.CONCLUSION:Hyperhomocysteinemia is an important risk factor for RVO, especially in patients with MTHFR C677T gene polymorphism.

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“…However, in a recent study, Al Wadani et al . [ 10 ] reported in the age and sex matched patient with retinal vein occlusion and controls showed the presence of hyperhomocysteinemia was a risk factor for the development of RVO in Indian population. Hence, the authors’ recommend investigating and treat for hyperhomocysteinemia in vaso-occlusive diseases like ophthalmic artery obstruction.…”

Section: Discussionmentioning

confidence: 99%

Spontaneous ophthalmic artery occlusion in children due to Hyperhomocysteinemia

Sachdeva¹,

Garg²,

Pathengay³

et al. 2015

Oman J Ophthalmol

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Ophthalmic artery occlusion usually presents as a sudden onset profound decrease in vision in the middle-aged and elderly patients following periocular procedures (retrobulbar injection/glabellar fat injection), embolism from the heart or after prolonged systemic surgery. In this report, we describe three children with spontaneous ophthalmic artery occlusion who presented with unilateral loss of vision and diagnosed elsewhere as optic atrophy whose detailed history and examination were suggestive of ophthalmic artery occlusion. Detailed systemic and laboratory evaluation revealed hyperhomocysteinemia as the only potential risk factor. To the best of our knowledge, this is the first report of the association of hyperhomocysteinemia and spontaneous ophthalmic artery occlusion.

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Hyperhomocysteinia is a risk factor for retinal venous occlusion: A case control study

Cited by 8 publications

References 29 publications

A study of serum homocysteine and serum vitamin B12 levels in patients with retinal vein occlusion and its correlation

A study of serum homocysteine and serum vitamin B12 levels in patients with retinal vein occlusion and its correlation

Investigation of methylenetetrahydrofolate reductase C677T and factor V Leiden mutation as a genetic marker for retinal vein occlusion

Spontaneous ophthalmic artery occlusion in children due to Hyperhomocysteinemia

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