Hypericum grandifolium Choisy: A species native to Macaronesian Region with antidepressant effect

Sánchez-Mateo, Candelaria C.; Bonkanka, C.X.; Rabanal, Rosa M.

doi:10.1016/j.jep.2008.10.031

Cited by 20 publications

(12 citation statements)

References 54 publications

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“…This assumption is consistent with our previous reports indicating synergistic and/or additive effects among several compounds in this species [8,20,21].…”

Section: Discussionsupporting

confidence: 94%

“…It is interesting to mention that previous studies from our group have shown that the methanol extracts, butanol and chloroform fractions and subfractions obtained from the chloroform fraction administered orally also possess an antidepressant effect in the forced swimming test [8,20], and anti-oedematogenic activity against carrageenaninduced paw oedema in mice [21] at the same doses that exert antinociceptive action, with the chloroform fraction being the most active in these studies.…”

Section: Discussionmentioning

confidence: 70%

“…Moreover, a wide range of pharmacological effects, including antidepressant [7,8], antinociceptive [9][10][11], anti-inflammatory [9][10][11][12], antioxidant [12], antimicrobial [13], hepatoprotective [14], and wound healing effects [15], have also been reported in other species of the genus Hypericum.…”

Section: Introductionmentioning

confidence: 99%

“…Studies carried out in our laboratories demonstrated that the infusion, methanol extract, butanol and chloroform fractions as well as subfractions obtained from the aerial part of the blossom of Hypericum grandifolium Choisy-a species endemic to the Macaronesian Region commonly known as ''malfurada'' in the Canary Islandsshowed an antidepressant activity in mice when assessed in the tetrabenazine and forced swimming test, without inducing significant muscle relaxation, anticholinergic and sedative properties [8,19,20]. Good antibacterial activity against Gram positive bacteria was also observed with the methanol extract as well as the chloroform and butanol fractions of this plant [13].…”

Section: Introductionmentioning

confidence: 99%

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Antinociceptive activity of Hypericum grandifolium Choisy in mice

2010

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The present study investigated the antinociceptive activity of different extracts prepared from the aerial parts of blossom of Hypericum grandifolium Choisy-a species native to the Macaronesian Region-using the acetic acid-induced writhing, formalin and tail flick test in mice. Oral administration of methanol extract (500 and 1,000 mg/kg p.o.), the aqueous, butanol and chloroform fractions (500 mg/kg p.o.) as well as subfractions F2 and F3 (45 mg/kg p.o.) from the chloroform fraction significantly inhibited acetic acid-induced writhing, with values ranging from 28 to 50% of inhibition. The methanol extract (1,000 mg/kg p.o.) and chloroform fraction (500 mg/kg p.o.) significantly reduced both phases of formalin-induced pain (with inhibition values ranging from 18 to 53%), whereas subfraction F2 (45 mg/kg p.o.) significantly inhibited the late phase (30%). In the tail flick assay, only the chloroform fraction (500 mg/kg p.o.) significantly prolonged the tail flick response. Different constituents, such as flavonoids and benzophenone derivatives, could account for the effects observed. Taking together, the results indicate that Hypericum grandifolium Choisy possesses both peripheral and central antinociceptive activities in mice, suggesting an interesting therapeutic potential for this species in pain diseases.

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“…This assumption is consistent with our previous reports indicating synergistic and/or additive effects among several compounds in this species [8,20,21].…”

Section: Discussionsupporting

confidence: 94%

Section: Discussionmentioning

confidence: 70%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Antinociceptive activity of Hypericum grandifolium Choisy in mice

2010

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“…Accumulating evidence supports the antidepressant activity of flavonoids in depression animal models [197-199]. Given the fact that depression and AD share common pathophysiological abnormalities of CREB- BDNF signaling pathway, citrus and green tea flavonoids may increase the phosphorylation of CREB and improve the memory [200,201].…”

Section: Preclinical Studies On Mechanisms Of the Antidepressants mentioning

confidence: 99%

Antidepressants are a rational complementary therapy for the treatment of Alzheimer's disease

Aboukhatwa

Dosanjh

Luo

2010

Mol Neurodegeneration

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There is a high prevalence rate (30-50%) of Alzheimer's disease (AD) and depression comorbidity. Depression can be a risk factor for the development of AD or it can be developed secondary to the neurodegenerative process. There are numerous documented diagnosis and treatment challenges for the patients who suffer comorbidity between these two diseases. Meta analysis studies have provided evidence for the safety and efficacy of antidepressants in treatment of depression in AD patients. Preclinical and clinical studies show the positive role of chronic administration of selective serotonin reuptake inhibitor (SSRI) antidepressants in hindering the progression of the AD and improving patient performance. A number of clinical studies suggest a beneficial role of combinatorial therapies that pair antidepressants with FDA approved AD drugs. Preclinical studies also demonstrate a favorable effect of natural antidepressants for AD patients. Based on the preclinical studies there are a number of plausible antidepressants effects that may modulate the progression of AD. These effects include an increase in neurogenesis, improvement in learning and memory, elevation in the levels of neurotrophic factors and pCREB and a reduction of amyloid peptide burden. Based on this preclinical and clinical evidence, antidepressants represent a rational complimentary strategy for the treatment of AD patients with depression comorbidity.

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Effects of Hypericum montbretti Extract on the Central Nervous System and Involvement of GABA (A)/Benzodiazepine Receptors in its Pharmacological Activity

Can

Özkay

2012

Phytotherapy Research

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The present study was undertaken to investigate the putative activity of a methanol extract of Hypericum montbretti (Guttiferae) on the central nervous system. Rutin (1519 ppm) and quercitrin (784 ppm) were identified as the major phenolic compounds in the extract. When administered at 25, 50 and 100 mg/kg doses, the extract decreased the total number of head-dipping behaviours performed by mice during a hole-board test. Administration of both the extract and diazepam (2 mg/kg) reduced spontaneous locomotory activity, potentiated hexobarbital (60 mg/kg)-induced sleeping parameters and prevented pentylenetetrazole (80 mg/kg)-induced seizures relative to the controls. These findings are the first to indicate the sedative and anticonvulsant activities of H. montbretti extract. Atropine (2 mg/kg) and naloxone (5 mg/kg) pre-treatment did not reverse the sedative effect, indicating that muscarinic and opioidergic mechanisms did not contribute to the pharmacological action. However, pre-treatment with flumazenil (a benzodiazepine receptor antagonist) reversed both the sedative and anticonvulsant effects induced by a 100 mg/kg dose of the extract, indicating the involvement of the GABA(A)-benzodiazepine receptor complex. In conclusion, H. montbretti extract is a novel candidate as a sedative and anticonvulsant drug for the treatment of sleep disorders and for the prevention of epileptic seizures.

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Hypericum grandifolium Choisy: A species native to Macaronesian Region with antidepressant effect

Cited by 20 publications

References 54 publications

Antinociceptive activity of Hypericum grandifolium Choisy in mice

Antinociceptive activity of Hypericum grandifolium Choisy in mice

Antidepressants are a rational complementary therapy for the treatment of Alzheimer's disease

Effects of Hypericum montbretti Extract on the Central Nervous System and Involvement of GABA (A)/Benzodiazepine Receptors in its Pharmacological Activity

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