Hypermethylation of collagen α2 (I) gene (COL1A2) is an independent predictor of survival in head and neck cancer

Misawa, Kiyoshi; Kanazawa, Takemichi; Misawa, Yuki; Imai, Atsushi; Endo, Shiori; Hakamada, Katsura; Mineta, Hiroyuki

doi:10.3233/cbm-2012-0242

Cited by 35 publications

(30 citation statements)

References 35 publications

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“…We observed in our results that the expression of COL1A2 was significantly elevated in gastric tumor tissues. In previous research, elevated COL1A2 expression has also been found in many different types of cancers, including breast cancer [22], head and neck cancer [4], and colorectal cancer [23]. We failed to observe the prognostic value of COL1A2 in the current analysis, whereas Misawa et al reported that the COL1A2 gene might serve as an important biomarker in head and neck squamous cell carcinoma [4].…”

Section: +contrasting

confidence: 52%

“…In previous research, elevated COL1A2 expression has also been found in many different types of cancers, including breast cancer [22], head and neck cancer [4], and colorectal cancer [23]. We failed to observe the prognostic value of COL1A2 in the current analysis, whereas Misawa et al reported that the COL1A2 gene might serve as an important biomarker in head and neck squamous cell carcinoma [4]. Controversy regarding the role of COL1A2 in various cancers exists, and we did not identify COL1A2 as a prognostic indicator of gastric cancer in this study.…”

Section: +mentioning

confidence: 99%

“…Developing countries in eastern Asia, eastern Europe and South America suffer from a higher incidence and mortality rate [3]. Moreover, GC accounts for approximately 20% of the global burden of disability-adjusted life-years, taking third place after lung and liver cancers [4]. GC is life-threatening due to its high incidence, mortality rate and impaired quality of life [3].…”

Section: Introductionmentioning

confidence: 99%

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Elevated THBS2, COL1A2, and SPP1 Expression Levels as Predictors of Gastric Cancer Prognosis

Zhuo

Zhuang

et al. 2016

Cell Physiol Biochem

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Background/Aims:Gastric cancer (GC) is an important health problem. Classification based on molecular subtypes may help to determine the prognosis of patients with GC. Tumor invasion and metastasis are important factors affecting the prognosis of cancer. We aimed to identify genes related to tumor invasion and metastasis, which may serve as indicators of good GC prognosis. Methods:Tumor tissues and adjacent normal tissues were collected from 105 patients with primary GC who were treated by undergoing radical surgery. Samples were used for tissue microarray analysis. Identified genes with altered expression were further analyzed using the Gene Ontology (Go) and Kyoto Encyclopedia of Genes and Genomes (KEGG) databases. The expression levels of THBS2, COL1A2 and SPP1 were analyzed by RT-PCR, western blot and immunohistochemistry. The overall survival curves of patients with high and low expression of each gene of interest were plotted and compared. Results:Forty-three genes were identified. THBS2, COL1A2 and SPP1 were selected for further analysis. Altered expression levels of THBS2, COL1A2 and SPP1 in tumor tissues were confirmed. Patients with low THBS2 expression had a better prognosis; the expression of COL1A2 and SPP1 might not affect the prognosis of patients with GC. Conclusion:THBS2, but not COL1A2 and SPP1, may serve as an indicator of GC prognosis.

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Section: +contrasting

confidence: 52%

Section: +mentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Elevated THBS2, COL1A2, and SPP1 Expression Levels as Predictors of Gastric Cancer Prognosis

Zhuo

Zhuang

et al. 2016

Cell Physiol Biochem

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“…However, the expression levels of COL1A1 and COL1A2 in malignant tumors remain controversial. On one hand, frequent promoter methylation of COL1A1 was detected in renal cell carcinoma and hepatocellular carcinoma [9, 10], and COL1A2 was downregulated in melanoma [11], head and neck cancer [14], and bladder cancer [15]. On the other hand, COL1A1 and COL1A2 mRNA was upregulated in colorectal cancer and medulloblastoma [16, 17].…”

Section: Discussionmentioning

confidence: 99%

Identification of COL1A1 and COL1A2 as candidate prognostic factors in gastric cancer

2016

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BackgroundThe role of type I collagen, composed of collagen type I alpha 1 (COL1A1) and collagen type I alpha 2 (COL1A2), has been studied in several cancers. However, the expression of COL1A1 and COL1A2 in malignant, premalignant, and normal gastric tissues and their clinical significances in gastric cancer have not been elucidated.MethodsReal-time quantitative PCR was performed in 55 malignant, 27 premalignant, and 19 normal tissues to measure COL1A1 and COL1A2 messenger RNA (mRNA) expression, and the correlations between COL1A1 and COL1A2 expression and clinicopathological parameters and patients’ survival rate were analyzed.ResultsWe found that COL1A1 mRNA expression was significantly upregulated in premalignant and malignant tissues than in normal tissues, whereas COL1A2 mRNA expression was significantly higher in malignant tissues than in premalignant and normal tissues. Moreover, COL1A1 expression was unrelated to clinicopathological parameters, while COL1A2 expression was positively related to tumor size and depth of invasion. Besides, higher COL1A1 and COL1A2 expression levels were related to lower overall survival.ConclusionsWe find that COL1A1 might have its potential as a monitoring factor to screen early gastric cancer, and COL1A1 and COL1A2 might predict poor clinical outcomes in gastric cancer patients.

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“…Endostatin, a collagen XVIII fragment, was shown to inhibit tumor progression by directly affecting the tumor cells, rather than only acting via the endothelial cells to block angiogenesis (21). Furthermore, the hypermethylation of COL1A2 was found to be an independent predictor of survival in patients with head and neck cancer (22).…”

Section: Col22a1 Col23a1mentioning

confidence: 99%

Prognostic value of type XXII and XXIV collagen mRNA expression in head and neck cancer patients

Misawa

Kanazawa

Imai

et al. 2013

Molecular and Clinical Oncology

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Abstract. Squamous cell carcinoma of the head and neck (HNSCC) is the sixth most common type of cancer, affecting ~500,000 individuals worldwide annually. Collagen is the major constituent of the extracellular matrix component in tumors and plays a crucial role in tumor development. The aim of this study was to determine the mRNA expression of type XXI, XXII, XXIII and XXIV α1 collagen (COL21A1, COL22A1, COL23A1 and COL24A1, respectively) in head and neck squamous cell carcinoma (HNSCC) and investigate its correlation with disease progression. This study investigated the mRNA expression levels of COL21A1, COL22A1, COL23A1 and COL24A1 in 70 HNSCC primary samples and 44 matched pairs of tumor and adjacent normal mucosal tissues using quantitative polymerase chain reaction (qPCR). Expression data were compared to the clinicopathological variables in order to determine the correlation between expression and disease progression. Our results demonstrated that the mRNA levels of COL22A1 and COL24A1 were significantly higher in HNSCC tissues compared to those in the corresponding normal tissues from the same individuals (n=44; P<0.001 and P=0.019, respectively). The COL22A1 mRNA levels were found to be significantly associated with lymph node metastasis (P=0.018) and pathological stage (P=0.024), whereas the COL24A1 mRNA levels were significantly associated with tumor size (P=0.045). The high expression levels of COL22A1 and COL24A1 mRNA were statistically correlated with a decrease in disease-free survival (DFS) (log-rank test, P<0.001). The results of the multivariate logistic regression analysis revealed that high expression levels of the COL22A1 and COL24A1 gene pair were associated with a high odds ratio for recurrence of 14.62 (95% confidence interval: 2.77-77.26; P=0.002). Therefore, the upregulation of COL22A1 and COL24A1 mRNA may play a critical role in the progression of HNSCC and provide useful information as a prognostic predictor for HNSCC patients.

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Hypermethylation of collagen α2 (I) gene (COL1A2) is an independent predictor of survival in head and neck cancer

Cited by 35 publications

References 35 publications

Elevated THBS2, COL1A2, and SPP1 Expression Levels as Predictors of Gastric Cancer Prognosis

Elevated THBS2, COL1A2, and SPP1 Expression Levels as Predictors of Gastric Cancer Prognosis

Identification of COL1A1 and COL1A2 as candidate prognostic factors in gastric cancer

Prognostic value of type XXII and XXIV collagen mRNA expression in head and neck cancer patients

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