Hyperostosis Frontalis Interna

Smith, S.; Hemphill, R. E.

doi:10.1136/jnnp.19.1.42

Cited by 15 publications

(4 citation statements)

References 12 publications

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“… 10 If cerebral compression and atrophy occur, it could potentially present with cognitive impairment or neuropsychiatric symptoms. 11 Hyperostosis frontalis interna has been classified by Hershkovitz et al 12 , 13 into 4 grades of severity and has also been classified with CT, but it remains uncertain how it would best be classified with regard to its impact on the likelihood of MRgFUS success.…”

Section: Discussionmentioning

confidence: 99%

Hyperostosis in Combination With Low Skull Density Ratio: A Potential Contraindication for Magnetic Resonance Imaging–Guided Focused Ultrasound Thalamotomy

Yuen¹,

Miller²,

Klassen³

et al. 2022

Mayo Clinic Proceedings: Innovations, Quality & Outcomes

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Since its approval in treating a number of movement disorders, magnetic resonance imaging–guided focused ultrasound (MRgFUS) has been adopted rapidly as one of the standard treatment modalities internationally. However, the efficiency of the energy delivered by the ultrasonic waves is largely determined by the highly variable bone morphology and density characteristics of the skull. One of the widely accepted indices used to facilitate patient selection is the skull density ratio (SDR). Earlier literature suggested that an SDR of less than 0.4 would be unfavorable for MRgFUS treatment. Some prior studies have excluded patients with hyperostosis. However, there is little published data regarding the impact of other skull features such as hyperostosis on treatment success. We present the case of a 66-year-old man with medically refractory essential tremor who had an SDR of 0.38 and extensive hyperostosis frontalis interna and underwent attempted MRgFUS thalamotomy treatment. However, intraoperatively the treatment was unsuccessful in generating sufficiently elevated temperature to create a lesion of the usual desired volume, and as expected, there was minimal clinical improvement. For comparison, we also summarize a case series of 4 other patients with an SDR of less than 0.4 who had successful outcomes. We believe that SDR should not be used as the only means of selecting patients for MRgFUS. Instead, important factors such as hyperostosis should be taken into consideration for patient selection and pretreatment counseling.

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Section: Discussionmentioning

confidence: 99%

Hyperostosis in Combination With Low Skull Density Ratio: A Potential Contraindication for Magnetic Resonance Imaging–Guided Focused Ultrasound Thalamotomy

Yuen¹,

Miller²,

Klassen³

et al. 2022

Mayo Clinic Proceedings: Innovations, Quality & Outcomes

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“…The phenomenon seems to be common because behavioral disturbances and the need for psychiatric care were the prominent features in all medical histories accessed on 13 cases of HFI on an autopsy study (9). Nevertheless, a significative correlation between neurological disorders and HFI is yet to be proven (12).…”

mentioning

confidence: 98%

Full Penetrance of Morgagni-Stewart-Morel Syndrome in a 75-Year-Old Woman: Case Report and Review of the Literature

Attanasio

Granziera

Giantin

et al. 2013

The Journal of Clinical Endocrinology & Metabolism

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A case of full penetrance of Morgagni-Stewart-Morel syndrome is reported, presenting many of the clinical features described in the literature. Metabolic and endocrine dysfunctions should be interpreted not only as isolated components of the syndrome, but also as the reason behind its pathogenesis. Endocrine or nutritional disorders may have led to an altered bone metabolism with frontal bone apposition. On the other hand, the severity of our patient's neurological and psychiatric symptoms correlates well with the severity of her hyperostosis frontalis interna and the cortical atrophy.

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“…The symptoms, diseases, and disorders of each patient with HFI were extracted individually. These conditions are listed in descending order of prevalence within the studies: Headaches were found in 51 patients (Elliott, et al, 2014; Andrews, 1942; Bracanovic et al, 2020; CARR, 1936; Chen & Murthy, 2012; Dann, 1951; Dumas et al, 1994; Harding, 1949; Khansare, 2014; Li et al, 2017; Lieberman & Ferry, 1974; Moore & Carr, 1952; NOTKIN, J., 1953; Priyambada et al, 2017; Ramchandren & Liebeskind, 2007; Sacher et al, 1985; Schmitt, 1976; Suárez Alvarez et al, 2004; Talarico et al, 2008; Willison et al, 1993; Yang et al, 2018); Obesity was found in 36 patients (Devriendt et al, 2005; Harding, 1949; She & Szakacs, 2004; Sommers, 1953; Torrealba‐Acosta & Mandel, 2020); Vertigo/Dizziness symptoms were found in 33 patients (Harding, 1949; Hasegawa et al, 1983; Moore & Carr, 1952; NOTKIN, J., 1953; Prakash et al, 2011; Talarico et al, 2008); Cognitive decline/Memory loss/Dementia were found in 30 patients (CARR, 1936; de Zubicaray et al, 1997; Devriendt et al, 2005; Gilbert et al, 2012; Khansare, 2014; Li et al, 2017; NOTKIN, J., 1953; Priyambada et al, 2017; Sacher et al, 1985; Waclawik, 2006); Psychological diagnosis were further categorized by specific diagnosis, depression was found in 27 patients (Harding, 1949; Khansare, 2014; NOTKIN, J., 1953; Otter et al, 2012; Smith & Hemphill, 1956; Torrealba‐Acosta & Mandel, 2020), unspecified psychological disorders were found in 17 patients (Devriendt et al, 2005; NOTKIN, J., 1953; Schmitt,…”

Section: Resultsmentioning

confidence: 99%

The clinical manifestations of hyperostosis frontalis interna: A qualitative systematic review of cases

Alvarez,

Corrigan,

McGonegal

et al. 2024

Clinical Anatomy

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Hyperostosis frontalis interna (HFI) is a condition defined as abnormal bone growth on the posterior aspect of the frontal bone. Despite uncertainties regarding its etiology and prognosis, clinicians typically consider HFI a benign pathology. There are no studies organizing all the possible manifestations of the disease. The present study aims to organize all the clinical manifestations of HFI within the current case report/series literature. A blinded PRISMA‐guided search of HFI case reports and case series yielded 43 relevant articles and provided 110 patients for analysis. The symptoms presenting alongside HFI were extracted and tabulated. We found high‐frequency clinical manifestations of HFI (>20% of patients) to include headaches, obesity, vertigo/dizziness symptoms, cognitive decline, and depression. An additional 15 symptoms were tabulated at frequencies found to be less than 20%. Based on our analysis, we suggest the constellation of high‐frequency symptoms can offer a more comprehensive clinical picture of symptomatic HFI which may be valuable to consider for clinicians and future researchers in the field of HFI.

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Hyperostosis Frontalis Interna

Cited by 15 publications

References 12 publications

Hyperostosis in Combination With Low Skull Density Ratio: A Potential Contraindication for Magnetic Resonance Imaging–Guided Focused Ultrasound Thalamotomy

Hyperostosis in Combination With Low Skull Density Ratio: A Potential Contraindication for Magnetic Resonance Imaging–Guided Focused Ultrasound Thalamotomy

Full Penetrance of Morgagni-Stewart-Morel Syndrome in a 75-Year-Old Woman: Case Report and Review of the Literature

The clinical manifestations of hyperostosis frontalis interna: A qualitative systematic review of cases

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