Hyperphagia of hyperthyroidism: Is neuropeptide Y involved?

Pétervári, Erika; Balaskó, Márta; Jech-Mihalffy, Andrea; Székely, Miklós

doi:10.1016/j.regpep.2005.07.004

Cited by 7 publications

(4 citation statements)

References 36 publications

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“…The exact mechanism for the increase in appetite associated with hyperthyroidism is poorly understood but studies suggest that suppression of leptin, increased hypothalamic neuropeptide Y, and enhanced phosphorylation of adenosine monophosphate (AMP)activated protein kinase may play a role (Pétervári et al, 2005;Ishii et al, 2008). Increased food intake and utilization of stored energy can initially compensate for the increased energy expenditure; however, ultimately chronic caloric and nutritional deficiency occurs.…”

Section: Polyphagiamentioning

confidence: 99%

Feline Hyperthyroidism

Scott‐Moncrieff¹

2015

Canine and Feline Endocrinology

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Section: Polyphagiamentioning

confidence: 99%

Feline Hyperthyroidism

Scott‐Moncrieff¹

2015

Canine and Feline Endocrinology

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“…Changes in food intake and energy balance are dependent on the actions of neurotransmitters and hormones, such as dopamine, PRL, leptin and insulin (Moore et al, 1986;Leinninger et al, 2009;Volkow et al, 2011;Chong et al, 2015). Besides, thyroid hormones exert important role in thermogenesis (Pétervári et al, 2005;Silva, 2011). All these hormones are influenced by dopamine (Kaptein et al, 1980;Gonzalez-Iglesias et al, 2008;Ustione and Piston, 2012;Alvarez-Aguilar et al, 2013), so it is plausible that improper neonatal dopaminergic stimulation may permanently alter some of these hormones parameters, explaining the observed changes in food consumption and metabolism.…”

Section: Effect Of Bro-treatment On the Food Intake Body Mass And Famentioning

confidence: 99%

Effects of postnatal bromocriptine injection on thyroid function and prolactinemia of rats at adulthood

et al. 2016

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“…Hyperthyroid patients have increased appetite and energy consumption [26]. It was found that T3 treated rats had a marked increase hypothalamic NPY and application of BIB03304 -antagonist of Y1 receptor reduced hyperphagia in thyrotoxicosis [25].…”

Section: Discussionmentioning

confidence: 99%

Estimation of gastric ghrelin-positive cells activity in hyperthyroid rats.

Dadan

Zbucki²,

Sawicki³

et al. 2009

Folia Histochem Cytobiol.

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Abstract:Ghrelin is a peptide of 28 amino acids that transmits appetite related signals from peripheral organs to the brain. The main source of ghrelin is stomach. The regulation of ghrelin secretion is still unknown. The finding that fasting and food intake, respectively increase and decrease the secretion of ghrelin suggests that this hormone may be a bridge connecting somatic growth with energy metabolism and appears to play an important role in the alteration of energy homeostasis and body weight in pathophisiological conditions. The purpose of this study was the evaluation of gastric ghrelin immunoreactivity and ghrelin plasma concentration in male Wistar rats with hyperthyroidism. Experimental model of hyperthyroidism was induced by intraperitoneal injection of levothyroxine at the dose of 80 μg/kg daily over 21 days. At the end of experiment the animals were anaesthetized, blood was taken from abdominal aorta to determinate plasma ghrelin concentration by RIA and then the animals underwent resection of distal part of stomach. Immunohistochemical study were performed using monoclonal specific antybodies against ghrelin. Hyperthyroidism was a reason of increase of gastric mucosal ghrelin -immunoreactivity, accompanied by a significant decreased of ghrelin plasma concentration. Those observations may indicate, that chronic administration of L-thyroxine cause the change of ghrelin plasma concentration in rats, probably via direct influence on gastric X/A-like cells, but this effect is not responsible for hyperphagia associated with hyperthyroidism.

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Hyperphagia of hyperthyroidism: Is neuropeptide Y involved?

Cited by 7 publications

References 36 publications

Feline Hyperthyroidism

Feline Hyperthyroidism

Effects of postnatal bromocriptine injection on thyroid function and prolactinemia of rats at adulthood

Estimation of gastric ghrelin-positive cells activity in hyperthyroid rats.

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