Hyperphosphataemia Is Associated with the Diabetes-related Cardiovascular Risk Factors

Mahmud, Ishtiaq; Rahman, Zillur; Keka, Islam Shamima; Devnath, Sudip; Masum, Nuruzzam; Hossain, Shahdat

doi:10.5650/jos.60.79

Cited by 4 publications

(7 citation statements)

References 31 publications

(21 reference statements)

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“…Hyperphosphatemia affirms the observations of Mahmud et al (2011) versus to Bicer et al (2011) who recorded the reverse result in diabetic rats. Also Duarte et al (2005) did not recorded a significant alteration in the serum inorganic phosphate resulted from alloxan treatment.…”

Section: Discussionsupporting

confidence: 87%

Serum Biochemical Altrations Following Alloxan- Induced Diabetes Mellitus in the Local Male Donkey

Kalo

2011

Assiut Veterinary Medical Journal

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Section: Discussionsupporting

confidence: 87%

Serum Biochemical Altrations Following Alloxan- Induced Diabetes Mellitus in the Local Male Donkey

Kalo

2011

Assiut Veterinary Medical Journal

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“…A high level of glycosylated haemoglobin (HbA1c) in smokers may be an indicator for insulin resistance, but the mechanism behind this is still unclear [17]. In an earlier study, S-P was shown to be a marker for glycaemia control [18]. …”

Section: Discussionmentioning

confidence: 99%

High serum phosphate and triglyceride levels in smoking women and men with CVD risk and type 2 diabetes

Håglin

Törnkvist²,

Backman

2014

Diabetol Metab Syndr

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BackgroundBoth low and high serum phosphate levels may be associated with morbidity and mortality from cardiovascular disease. As smoking increases risk for type 2 diabetes (as shown by dyslipidemia and hyperglycemia), we wanted to study whether smoking and type 2 diabetes were associated with serum phosphate and triglyceride levels independently from other CVD risk factors.MethodsUpon admittance to the Vindeln Health Education Centre (VHE-centre) for a four-week comprehensive lifestyle intervention, the participants (1408 women and 1096 men) completed a questionnaire that included their smoking habits – current smoker or non-smoker. We used multiple linear regression analyses to investigate the association between smoking and other CVD risk factors with S-P and S-TG levels.ResultsIn the non-type 2 diabetes populations, the smokers, compared to the non-smokers, had higher S-P and higher serum triglycerides (S-TG). In women, serum-TG in smokers with type 2 diabetes was higher than in smokers with non-type 2 diabetes. Non-type 2 diabetes patients exhibited an inverse relation between S-Glucose (S-Glu) and S-P and a positive association with S-TG. For men only, an association was seen between age (-) and S-Crea (-) and S-P. For women only, an association was seen between BMI (-) and S-Cholesterol (+) (S-Chol) and S-P.ConclusionsCompared to non-smokers, smoking women with non-type 2 diabetes and smoking men with type 2 diabetes had a higher level of S-P and S-TG. The association between smoking and S-P and S-TG levels still existed after adjusting for age and CVD risk factors in the multiple linear regression analyses.Trial registrationThe study has been registered as a sub-study to the Lifestyle Intervention Trial no. ISRCTN79355192.

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“…Increases in ROS production activate the unfolded protein response (UPR), which causes phosphorylation of double-stranded RNA-dependent protein kinase-like ER kinase (PERK) and eukaryotic translation initiation factor 2α (eIF2α) due to high phosphate levels, causing attenuation of insulin translation [ 5 , 41 ]. A decrease in insulin release allows high glucose levels to remain in the circulatory system, further exacerbating diabetes [ 41 , 43 ]. Phosphate burden should be controlled actively to attenuate its negative effects on insulin and help prevent one of the ways an individual may develop metabolic syndrome (fasting glucose ≥ 100 mg/dL).…”

Section: Phosphate Burden and Glucose Metabolismmentioning

confidence: 99%

“…Human and experimental studies have consistently demonstrated a higher phosphate burden induces cardiovascular calcification, hypertension, musculoskeletal disorders, and premature aging [ 4 ]. In a study conducted on 104 diabetic patients, the serum phosphate level was markedly higher in cardiovascular disease patients [ 43 ]. Simple regression analyses found a positive correlation between serum levels of phosphate and serum levels of total cholesterol ( p < 0.05, r = 0.35), triglyceride ( p < 0.05, r = 0.75) and fasting glucose ( p < 0.05, r = 0.75) [ 43 ].…”

Section: Phosphate Burden and Cardiometabolic Disordersmentioning

confidence: 99%

“…In a study conducted on 104 diabetic patients, the serum phosphate level was markedly higher in cardiovascular disease patients [ 43 ]. Simple regression analyses found a positive correlation between serum levels of phosphate and serum levels of total cholesterol ( p < 0.05, r = 0.35), triglyceride ( p < 0.05, r = 0.75) and fasting glucose ( p < 0.05, r = 0.75) [ 43 ]. According to Mahmud et al, all cardiac patients in their study had poor glycemic control and found a linear and significant increase in triglycerides in these patients [ 43 ].…”

Section: Phosphate Burden and Cardiometabolic Disordersmentioning

confidence: 99%

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Phosphate Dysregulation and Metabolic Syndrome

2022

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Phosphorus is one of the most abundant minerals in the human body. It is essential for almost all biochemical activities through ATP formation, intracellular signal transduction, cell membrane formation, bone mineralization, DNA and RNA synthesis, and inflammation modulation through various inflammatory cytokines. Phosphorus levels must be optimally regulated, as any deviations may lead to substantial derangements in glucose homeostasis. Clinical studies have reported that hyperphosphatemia can increase an individual’s risk of developing metabolic syndrome. High phosphate burden has been shown to impair glucose metabolism by impairing pancreatic insulin secretion and increasing the risk of cardiometabolic disorders. Phosphate toxicity deserves more attention as metabolic syndrome is being seen more frequently worldwide and should be investigated further to determine the underlying mechanism of how phosphate burden may increase the cardiometabolic risk in the general population.

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Hyperphosphataemia Is Associated with the Diabetes-related Cardiovascular Risk Factors

Cited by 4 publications

References 31 publications

Serum Biochemical Altrations Following Alloxan- Induced Diabetes Mellitus in the Local Male Donkey

Serum Biochemical Altrations Following Alloxan- Induced Diabetes Mellitus in the Local Male Donkey

High serum phosphate and triglyceride levels in smoking women and men with CVD risk and type 2 diabetes

Phosphate Dysregulation and Metabolic Syndrome

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