Hyperpigmentation: types, diagnostics and targeted treatment options

Nieuweboer‐Krobotova, L.

doi:10.1111/jdv.12048

Cited by 29 publications

(28 citation statements)

References 4 publications

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“…These brown-grey macules sometimes show erythematous borders [4,5]. Although the etiology of EDP is unclear there are some probable genetic factors related by genes located in the major histocompatibility complex region [6].…”

Section: Discussionmentioning

confidence: 99%

Erythema Dyschromicum Perstans: A Case Report

Durmaz¹,

Özer²,

Fındık³

et al. 2017

J Pigment Disord

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Erythema dyscromicum perstans (EDP) or Ashy dermatosis is an uncommon pigmentary disorders which characterized with asymptomatic gray symmetric confluent macules over the body. It usually starts between first to three decades of the life and has a slow onset. This ailment can affect the palms, soles, scalp, nails and mucous membranes. Despite the definition of some etiological factors, the exact etiology of EDP is not clear. In this paper, we present a 24 years old patient with EDP.

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Section: Discussionmentioning

confidence: 99%

Erythema Dyschromicum Perstans: A Case Report

Durmaz¹,

Özer²,

Fındık³

et al. 2017

J Pigment Disord

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“…Although the pathogenesis for each hyperpigmented lesion type is not fully understood, it seems it is common across all types of hyperpigmentation that excessive melanin is either produced or maintained in epidermis. Though melanin plays an important role, each type of spot has unique features beyond melanin amount, such as depth of melanin deposition, pattern of melanosome distribution, epidermal thickness, shape of epidermal‐dermal junction, thus demand specific treatment for each type of hyperpigmented spot …”

Section: Introductionmentioning

confidence: 99%

“…Broadly speaking, hyperpigmented facial lesions belong to a wider class of skin lesions. Even though histopathology is the gold standard for correct diagnosis of skin lesions, non‐invasive measurements are increasingly being performed in clinical practice to diagnose hyperpigmented lesions . In the conventional research setting, diagnosis of hyperpigmented spot lesions relies on dermatologist visual assessment, often with the aids of objective tools such as magnifier, dermascope, colorimeter or spectral meter .…”

Section: Introductionmentioning

confidence: 99%

Inter‐ and intra‐observer agreement in dermatologists’ diagnoses of hyperpigmented facial lesions and development of an algorithm for automated diagnosis

Huang

et al. 2019

Skin Res Technol

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Background: Hyperpigmentation has varied aetio-pathologies. Hence, accurate and reproducible diagnosis of the type of hyperpigmentation is essential for effective management. It is typically made clinically by dermatologists but the rate of inter-and intra-observer agreement/variability is unknown. Hyperpigmented facial lesions are extremely common but access to dermatological services is difficult or costly in most countries. Thus, it is desired to evaluate dermatologists' inter-and intra-observer agreement in the diagnosis and to develop an algorithm for automated diagnosis. Materials and Methods:Hyperpigmented lesions on 392 facial images were diagnosed by three experienced dermatologists either jointly or independently, and this process was subsequently repeated for 52 randomly selected images. When there was non-concordance amongst the dermatologists for the diagnosis, a majority decision was taken as correct diagnosis. Inter-observer and intra-observer agreement were analysed for the diagnosis of the hyperpigmented lesions. Thereafter, a multiclass classification method was developed to perform the task in an automatic manner. The developed algorithm was compared and validated against the ground truth derived from the dermatologists. Results:Both inter-and intra-observer agreements are in the moderate range. The algorithm agreed well with the derived ground truth, with a Kappa value of 0.492, which is similar to the Kappa values of inter-and intra-observer agreements. Conclusion:The rates of inter-and intra-observer agreement in the diagnosis of hyperpigmented facial lesions amongst dermatologists were moderate in this study.Compared to visual assessment from the dermatologists, automated diagnosis using the developed algorithm achieved a high rate of concordance. K E Y W O R D S automated diagnosis, feature extraction, hyperpigmented facial lesion diagnosis, hyperpigmented lesion classification, inter-and intra-observer agreements, Kappa value, multiclass classification S U PP O RTI N G I N FO R M ATI O N Additional supporting information may be found online in the Supporting Information section at the end of the article. How to cite this article: Yu P, Li X, Huang Y, et al. Inter-and intra-observer agreement in dermatologists' diagnoses of hyperpigmented facial lesions and development of an algorithm for automated diagnosis. Skin Res Technol. 2019;25:777-786. https ://doi.

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“…A localized hyperpigmented lesion, also known as age spot, solar, or senile lentigo, is one of the most visible alterations in photoaged skin, especially in Asian and Caucasian populations . In fact, these benign‐pigmented lesions are not only considered unattractive on visible body areas (face, dorsum of the hand, upper back, and extensor forearm), but they are also a clinical marker of the degree of skin photodamage . The molecular mechanisms responsible for photoaged hyperpigmentation are not completely known, but they do depend on the cumulative dose of sun exposure as well as on the amount of protection provided by its pigmentation .…”

Section: Introductionmentioning

confidence: 99%