Hypersensitive detection of IL-6 on SERS substrate calibrated by dual model

Zhou, Ting; Lu, Dechan; She, Qiutian; Chen, Cairou; Huang, Zufang; Feng, Shouhua; You, Ruiyun; Lu, Yue

doi:10.1016/j.snb.2021.129597

Cited by 20 publications

(12 citation statements)

References 29 publications

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“…Lu et al successfully fabricated an AgNPs@glass plate 2D SERS substrate for the detection of Interleukin-6 in plasma at a trace level. 214 This sensing method involves Prussian blue (PB) molecule embedded with Au@AuNPs (Au@PB@AuNPs) used as SERS tags and IL-6 antibody immobilized Au@Au core−shell nanoprobes for selectively recognizing IL-6 glycoprotein in the whole process, as seen in Figure 10a. This SERS substrate showed linear range of 0.5−50000 pg/mL (R 2 = 0.9928), and the detection limit was 5 pg/mL in serum.…”

Section: Chemiluminescence (Cl)mentioning

confidence: 99%

“…Recently, SERS-based biosensors have received much attention in the analysis of cardiovascular disease biomarkers. Lu et al successfully fabricated an AgNPs@glass plate 2D SERS substrate for the detection of Interleukin-6 in plasma at a trace level . This sensing method involves Prussian blue (PB) molecule embedded with Au@AuNPs (Au@PB@AuNPs) used as SERS tags and IL-6 antibody immobilized Au@Au core–shell nanoprobes for selectively recognizing IL-6 glycoprotein in the whole process, as seen in Figure a.…”

Section: Optical Signaling Readout-based Nanobiosensorsmentioning

confidence: 99%

Section: Optical Signaling Readout-based Nanobiosensorsmentioning

confidence: 99%

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Optical Nanobiosensor-Based Point-of-Care Testing for Cardiovascular Disease Biomarkers

Vairaperumal,

Huang,

Liu

2023

ACS Appl. Bio Mater.

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Cardiovascular disease is a global health threat, and detecting cardiac biomarkers is essential for early-stage diagnosis and personalized treatment. Traditional approaches have limitations, but optical nanobiosensors offer rapid, highly selective, and sensitive detection. Optical nanobiosensors generate biosignals that transfer light signals while analytes bind with the bioreceptors. Optical nanobiosensors have advantages such as ease of monitoring, low cost, a wide detection range, and high sensitivity without any interference. An optical nanobiosensor platform is a promising approach for point-of-care cardiac biomarker detection with a low detection limit. This review mainly focuses on the detection of cardiovascular disease biomarkers based on various optical nanobiosensor approaches that have been reported during the last five years, and we have categorized them based on optical signal readouts. A detailed discussion of the classification of cardiovascular disease biomarkers, design strategies of optical biosensors, types of optically active nanomaterials, types of bioreceptors, functionalization techniques, various assay types, and sensing mechanisms is presented. Then, we summarize the optical signaling readout-based various nanobiosensors systems for the detection of cardiovascular disease biomarkers. Finally, we summarize and conclude with the recent development of point-of-care testing (PoCT) for cardiovascular disease biomarkers used in various optical readout techniques.

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Section: Chemiluminescence (Cl)mentioning

confidence: 99%

Section: Optical Signaling Readout-based Nanobiosensorsmentioning

confidence: 99%

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Optical Nanobiosensor-Based Point-of-Care Testing for Cardiovascular Disease Biomarkers

Vairaperumal,

Huang,

Liu

2023

ACS Appl. Bio Mater.

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“…PB is used as IS molecules and is further protected by Au shell, significantly improving the linearity of IL-6 detection. 81 …”

Section: Biological Applications Of Prussian Blue-based Sers Nanotagsmentioning

confidence: 99%

Recent advances in plasmonic Prussian blue-based SERS nanotags for biological application

Liu

Zhu

et al. 2021

Nanoscale Adv.

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“…The signal is significantly enhanced after being modified with AgNPs, 43 so it is often designed as SERS tags for the detection of glycoproteins. [44][45][46] In this paper, we designed a CEA SERS aptamer sensor based on silver nanorod array chips, thiol aptamers, and 4-MPBA. The silver nanorod array modified with CEA thiol aptamer was used as the SERS capture substrate (Chip@Apt), and Ag@4-MPBA was used as the SERS tag.…”

Section: Introductionmentioning

confidence: 99%

Construction of a Carcinoembryonic Antigen Surface-Enhanced Raman Spectroscopy (SERS) Aptamer Sensor Based on the Silver Nanorod Array Chip

Zhang

et al. 2022

Appl Spectrosc

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Carcinoembryonic antigen (CEA) is a cancer-related tumor marker, and it is important to develop a sensitive CEA detection technique. In this paper, a SERS-aptamer sensor for carcinoembryonic antigen (CEA) was based on thiol aptamer and phenylboronic acid. CEA thiol aptamer (Aptamer-SH) modified silver nanorod array chip was used as the SERS capture substrate. 4-Mercaptophenylboronic acid (4-MPBA) modified Ag NPs was used as SERS tags (Ag@4-MPBA). The affinity of the aptamer with CEA was used to ensure the selectivity of the sensor, while 4-MPBA could be recognized with glycoproteins and reduce the cost. The results showed that the SERS intensity and the logarithm of CEA concentrationa had a good linear relationship in the range of 1 pg/mL-100 ng/mL, with a correlation coefficient (R2) of 0.9907. The limit of detection (LOD) was 0.447 pg/mL (S/N=3); the recovery of the standard addition test for CEA in serum was between 97.25% and 102.67%, and the RSD ≤ 2.52% (n=3). The sensor has the advantages of high sensitivity, wide linear range, and stability. It provides a possible method for the detection of CEA in serum.

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Hypersensitive detection of IL-6 on SERS substrate calibrated by dual model

Cited by 20 publications

References 29 publications

Optical Nanobiosensor-Based Point-of-Care Testing for Cardiovascular Disease Biomarkers

Optical Nanobiosensor-Based Point-of-Care Testing for Cardiovascular Disease Biomarkers

Recent advances in plasmonic Prussian blue-based SERS nanotags for biological application

Construction of a Carcinoembryonic Antigen Surface-Enhanced Raman Spectroscopy (SERS) Aptamer Sensor Based on the Silver Nanorod Array Chip

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