Hypersensitivity pneumonitis with antibodies to <i>Cryptococcus neoformans</i>

Miyagawa, Toshi; Ochi, Tadao; Takahashi, H.

doi:10.1111/j.1365-2222.1978.tb01503.x

Cited by 30 publications

(7 citation statements)

References 22 publications

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“…A T. beigelii cell wall antigen produces false positive latex agglutination tests for cryptococcal antigen and cross-reacts with C. neoformans capsular polysaccharide [48,49]. Serum anti-C. neoformans antibodies have been reported in patients with hypersensitivity pneumonitis [50]. Our discovery of serum GXM in 6 5% of HIV'*' individuals in Bronx, NY, confirms a recent report of a 6% prevalence of CM in patients with AIDS in New York City [2].…”

Section: Discussionsupporting

confidence: 80%

Antibodies to theCryptococcus neoformanscapsular glucuronoxylomannan are ubiquitous in serum from HIV+ and HIV− individuals

DeShaw

Pirofski

1995

Clinical and Experimental Immunology

104

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SUMMARYMurine MoAbs to the Cryptococcus neoformans capsular glucuronoxylomannan (GXM) polysaccharide are protective in mice in vivo and in vitro. The prevalence of protective anti-GXM antibodies in human serum is unknown. To provide further insight into the human antibody response to C. neoformans we determined the prevalence, isotype, and IgG subclass utilization of human anti-GXM antibodies in HIV+ and HIV-sera by a sensitive antigen capture ELISA assay. One hundred and twenty-three sera from the Bronx Municipal Hospital Centre serum bank were studied retrospectively. Seventy were from HIV+ individuals, 10 with a history of cryptococcal meningitis (CM), and 53 were from HIV-individuals. Serum GXM determinations were also performed on 61 HIV+ sera. Our results demonstrated that anti-GXM IgG, IgA, and IgM are ubiquitous in both HIV+ (including those with CM), and HIV-sera. Anti-GXM IgA titres and total serum IgA concentration were elevated in HIV+ sera. Anti-GXM IgG antibodies were almost exclusively isotype-restricted to the IgG2 subclass. Our data also demonstrated elevations of antibovine serum albumin (BSA) titres in HIV+ sera. Taken together, our findings confirm hypergammaglobulinaemia and expansion of anti-protein (BSA) antibodies in HIV+ individuals and isotype restriction of human anti-carbohydrate (GXM) antibodies to the IgG2 subclass. Our report of ubiquitous anti-GXM antibodies of the IgG and IgA isotypes suggests that anti-GXM antibodies exist before HIV infection.

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Section: Discussionsupporting

confidence: 80%

Antibodies to theCryptococcus neoformanscapsular glucuronoxylomannan are ubiquitous in serum from HIV+ and HIV− individuals

DeShaw

Pirofski

1995

Clinical and Experimental Immunology

104

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“…The application of indirect immunofluorescence technique, using Cr. neoformans cells, revealed the presence of anli-Cryptoeoccus antibody in almost all sera from patients with summer-type HP (over 100 patients) and in about 65",, of sera from their family members, and contrasts with less than 10% of sera from healthy subjects and various lung diseases (Miyagawa et al, 1978). However, microbiological studies revealed no Cr.…”

Section: Discussionmentioning

confidence: 97%

“…Exposure and sensitization to such organisms might have caused the summer-type HP. AnU-Cryptococcus antibody titres changes in correlation with clinical course of summer-type HP (Miyagawa et al, 1978).…”

Section: Discussionmentioning

confidence: 99%

Japanese summer‐type hypersensitivity pneumonitis: studies using Cryptococcus antigen

Miyagawa

Hamagami

Ochi

et al. 1982

Clin Experimental Allergy

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Sixty-six patients, diagnosed as Japanese summer-type hypersensitivity pneumonitis at Osaka Prefectural Habikino hospital between 1973 and 1980, were studied. The diagnosis was based on the clinical features and summer-seasonal nature of the disease. The presence of an aetiological agent within patients" home environment was suggested by the recurrence of acute symptoms of high fever, cough and dyspnoea 5-8 hr after coming home from hospital, and by spontaneous improvement on leaving home, immunological studies revealed the presence of -dnU-Cryptoeoceus antibody in sixty-four of sixty-five patients' sera, by indirect immunofluorescence against Cryptococcus neoformans. Precipitating antibody against culture supernatant protein-antigen of Cr. n<'o/()rmam was detected in more than 80% of sera obtained from patients during the active stage of the disease. The positive result on inhalation provocation-challenge, using culture supernatant protein-antigen, suggested that Cr. neoformans or antigenically related Cryptococcus species may cause Japanese summer-type hypersensitivity pneumonitis. Recent studies reveal that patients with HP have been increasing during the past 10 years in Japan. Hypersensitivity pneumonitis in Japan, including our cases, was

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“…Nine patients with summer type HP (a unique form of HP in Ja pan) showed the following characteristics as well as the features of well-documented H P [9][10][11][12]: (1) the onset of disease in May through September (summer); (2) the recurrence of symptoms after return ing home during the hospitalization in season, and (3) anticryptococcal antibody in sera detected by an indirect immunofluorescent method.…”

Section: Subjectsmentioning

confidence: 99%

Analysis of Bronchoalveolar Lavage Cells and Fluids in Patients with Hypersensitivity Pneumonitis: Possible Role of Chemotactic Factors in the Pathogenesis of Disease

Yoshizawa

Ohdama

Tanoue

et al. 1986

Int Arch Allergy Immunol

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The current study concerns immunological mechanisms involved in the pathogenesis of hypersensitivity pneumonitis (HP) by an analysis of the cells and chemotactic factors (CF) obtained by bronchoalveolar lavage (BAL). Nine patients at an acute stage (HP acute, 8 summer type and 1 pigeon breeder’s lung) and 4 patients at a quiescent stage (HP quiescent, 3 summer type and 1 pigeon breeder’s lung) were included. The results indicate that: (1) CF for polymorphonuclear cells (PMN) in HP acute were significantly more potent than in HP quiescent; (2) CF for mononuclear cells were not significantly different in the groups; (3) the percentage of lymphocytes in HP acute was significantly greater even though HP quiescent revealed greater percentages of lymphocytes as compared to normal controls; (4) determination of T cell subsets employing OKT antibodies revealed the ratio of OKT8⁺ cells to OKT4⁺ cells in HP acute was significantly higher than in HP quiescent, and (5) chemotaxis for PMN was marginally correlated with the percentage of OKT8⁺ cells at the acute stage of disease.

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Hypersensitivity pneumonitis with antibodies to Cryptococcus neoformans

Cited by 30 publications

References 22 publications

Antibodies to theCryptococcus neoformanscapsular glucuronoxylomannan are ubiquitous in serum from HIV+ and HIV− individuals

Antibodies to theCryptococcus neoformanscapsular glucuronoxylomannan are ubiquitous in serum from HIV+ and HIV− individuals

Japanese summer‐type hypersensitivity pneumonitis: studies using Cryptococcus antigen

Analysis of Bronchoalveolar Lavage Cells and Fluids in Patients with Hypersensitivity Pneumonitis: Possible Role of Chemotactic Factors in the Pathogenesis of Disease

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