Hypertension, calcium channel and pyridoxine (vitamin B6)

Assessment of the Effect of Pyridoxine Hydrochloride Supplementation on Anthropometric Measurements, Body Composition, Visceral Adiposity Index and Metabolic Status in Obese and Overweight Women

“…Beside dietary source, the gut microbiota is an important source of vitamin B6 production in the colon (6).Vitamin B6 acts as an important coenzyme in various reactions in the body, including: metabolism of amino acids, glucose release from glycogen, modulation and regulation of steroid hormone receptors, tryptophan conversion to niacin and Biosynthesis of sphingolipids (6). It is also played a role in the biosynthesis of dopamine, serotonin and gammaaminobutyric acid neurotransmitters that regulate various functions like blood pressure, mental state and depression and appetite (7)(8)(9).In some studies the effects of pyridoxine on calcium ion signaling have been observed that increases lipolysis and decreases fatty acid synthesis (10)(11)(12). In some studies, it has also been shown to decrease insulin resistance (13)(14)(15)(16) and improved lipid pro le (13,(17)(18)(19).…”

Treatment of Hypertension with Nutrition and Nutraceutical Supplements: Part 2

“…[1][2][3][4] Vitamin B6 (Pyridoxine) Low serum vitamin B6 (pyridoxine) levels are associated with hypertension in humans. [1][2][3][4][24][25][26][27][28] High-dose vitamin B6 significantly lowered BP by 14/10 mmHg (P < 0.005) and serum catecholamine levels (P < 0.05) in a placebo-controlled study of 20 hypertensive subjects who were administered vitamin B6 at 5 mg/kg/day for four weeks. 25 In a placebo-controlled trial over 12 weeks, in which participants were given 800 mg lipoic acid and 80 mg pyridoxine, results showed that serum lipoic acid and pyridoxine, urinary albumin, serum malondialdehyde, and SBP decreased significantly in the supplement group compared to the placebo group (P < 0.05).…”

Vitamin B-6 Metabolism and Interactions with TNAP

“…The 250 mg dose was more effective than 750 mg. An editorial discussing those results suggested that improved efficacy may require targeting multiple receptors or perhaps a central control point in the relevant metabolic pathway (Verrier 2007). Pyridoxal phosphate may also interact with calcium channels (Dakshinamurti et al 1998). Microinjection of pyridoxal phosphate causes seizures which were attributed to extracellular pyridoxal phosphate interacting with GABA A receptor (Salazar and Tapia 2001).…”