Hyperthermia – description of a method and a review of clinical applications

Chicheł, Adam; Skowronek, Janusz; Kubaszewska, M.; Kanikowski, Marek

doi:10.1016/s1507-1367(10)60065-x

Cited by 237 publications

(163 citation statements)

References 51 publications

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“…5,6 Temperature induced modification of nuclear proteins have not only the effect of driving cell to death but it is also thought to be the central event by which heat makes tumor cells more "sensitive" to external stimulus leading, for example, to a beneficial synergy between heat and radiation. 7,8 Moreover, the combination of drugs and local heating has also attracted a great attention during last years. 9,10 The particular method applied to achieve controlled hyperthermia depends on the nature, size, and location of the area to be treated.…”

mentioning

confidence: 99%

Nd3+ doped LaF3 nanoparticles as self-monitored photo-thermal agents

Rocha

Kumar

Jacinto

et al. 2014

Applied Physics Letters

129

105

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In this work, we demonstrate how LaF 3 nanoparticles activated with large concentrations (up to 25%) of Nd 3þ ions can simultaneously operate as biologically compatible efficient nanoheaters and fluorescent nanothermometers under single beam (808 nm) infrared laser excitation. Nd 3þ :LaF 3 nanoparticles emerge as unique multifunctional agents that could constitute the first step towards the future development of advanced platforms capable of simultaneous deep tissue fluorescence bio-imaging and controlled photo-thermal therapies. V C 2014 AIP Publishing LLC.

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mentioning

confidence: 99%

Nd3+ doped LaF3 nanoparticles as self-monitored photo-thermal agents

Rocha

Kumar

Jacinto

et al. 2014

Applied Physics Letters

129

105

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“…Recently, there were many reviews about hyperthermia randomized trials and indicated that it can enhance the efficacy of both radiotherapy and chemotherapy, and also many non-and randomized clinical trials have demonstrated the significant improvement in clinical outcome from adding hyperthermia to standard treatment regimens of radiation and/or chemotherapy [26][27][28][29][30][31][32][33][34] . Maluta, et al 37,38) .…”

Section: - -mentioning

confidence: 99%

Thermal Therapy as Multidisciplinary Therapy Applied to Rectal Cancer:

et al. 2017

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To avoid colostomy, we try to improve local control, i.e. to perform pathological complete response (pCR) by the neoadjuvant chemoradiation (NACR) with concurrent thermal therapy, falling into a so-called "wait-and-see policy". The aim of this study is examined whether the treatment response of NACR with concurrent thermal therapy for rectal cancer can be predicted after the treatment completion and we showed the changing history of our treatment protocol, current results of our study and a new perspective and potential role of thermal therapeutic approaches in patients with rectal cancer. In this study, 81 patients with rectal cancers (54 resected, M:F＝61:20, median age 63 years old (33-89), from December 2011 to May 2015) were received intensity-modulated radiotherapy (IMRT) (total dose 50 Gy/25 fractions) with capecitabine (1,700 mg/m 2 / day) for five weeks. Thermal therapy was performed using the Thermotron-RF 8, once a week for 5 weeks with 50 min irradiation. Clinical complete response (CR), partial response (PR), stable disease (SD), and progressive disease (PD) were shown in 33.4%, 38.3%, 12.3%, and 16.0% of the patients, respectively. Patients with a gross tumor volume (GTV) ≤ 32 cm 3 and a radiofrequency (RF) output difference (RO difference) ≥ 0 Watt/min exhibited the rates of pathological complete response (pCR) 42.9% and complete response (CR) 71.4%, and those with RO difference＜0 Watt/min, 23.1% and 92.3%, respectively. While, patients with a GTV ≥ 80 cm 3 and a RO difference ≥ 0 Watt/min exhibited the rates of pCR and CR 23.1% and 30.8%, and those with RO difference＜0 Watt/min, 0% and 0%, respectively. Skin temperature significantly changed in patients with a pathological grade 3 tumor compared both to those who had PD and other outcomes, in the Therapeutic potential of thermal therapy H. Shoji et al. 75- -

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“…Hyperthermia is a treatment method in which the body is exposed to elevated temperatures (often 45°C) locally or regionally. 4,5 At these elevated temperatures, cells will either be killed or severely damaged, allowing for radiation and chemotherapy to be more effective at lower doses. 6 While the idea of using heat to treat cancer and other illnesses is far from new -hyperthermia treatments can be dated back to the ancient Egyptian era 6 advances in optics, biotechnology, nanomaterials, and medicine have all contributed to the reality of using thermal therapy as a viable option.…”

Section: Introductionmentioning

confidence: 99%

“…Oxidative-emulsion polymerization is one method that can be used to overcome this limitation. In this work, we demonstrate the preparation of two types of low oxidation potential CPNPs based on poly(diethyl-4,4′-{[2,5-bis(2,3-dihydrothieno [3,4-b] [1,4]dioxin-5-yl)-1,4-phenylene] bis(oxy)}dibutanoate) (P1) and poly(3,4-ethylenedioxythiophene) (PEDOT) stabilized with 4-dodecylbenzenesulfonic acid (DBSA) and poly(4-styrenesulfonic acid-co-maleic acid) (PSS-co-MA) via oxidative-emulsion polymerization and their evaluation as PTT agents. The effect of chemical structure of the two polymers on the absorption properties of the NPs and, thereby, on their effectiveness as agents for photothermal ablation was studied.…”

Section: Introductionmentioning

confidence: 99%