Nd3+ doped LaF3 nanoparticles as self-monitored photo-thermal agents

Abstract

In this work, we demonstrate how LaF 3 nanoparticles activated with large concentrations (up to 25%) of Nd 3þ ions can simultaneously operate as biologically compatible efficient nanoheaters and fluorescent nanothermometers under single beam (808 nm) infrared laser excitation. Nd 3þ :LaF 3 nanoparticles emerge as unique multifunctional agents that could constitute the first step towards the future development of advanced platforms capable of simultaneous deep tissue fluorescence bio-imaging and controlled photo-thermal therapies. V C 2014 AIP Publishing LLC.

Neodymium‐Based Stoichiometric Ultrasmall Nanoparticles for Multifunctional Deep‐Tissue Photothermal Therapy

“…4(b). [26] At this point it should be noted that, although the same diode laser was used in both cases, for experiments involving the Nd:LaF3 NPs the diode wavelength was temperature tuned down to 802 nm in order to increase the optical absorption of Nd:LaF3 NPs (whose absorption spectrum peaks at 790 nm). [27] As we mentioned before, Nd:LaF3 NPs have been successfully used as therapeutic photothermal agents, however, their heating curve has a less pronounced slope (below 5 ºC·cm 2 ·W -1 ).…”

Infrared‐Emitting QDs for Thermal Therapy with Real‐Time Subcutaneous Temperature Feedback

“…To calculate the photothermal conversion efficiency of PbS/CdS/ZnS QDs, we followed the method described in different works based on the report presented by Roper et al [13] An aqueous dispersion of QDs (1 mg/mL) was placed in an open quartz cuvette and irradiated with an 808 nm laser diode at a power of 403 mW, while continuously monitoring its temperature with a thermographic camera. The laser was turned off when the temperature reached a steady value (18 minutes after starting the irradiation), and the temperature was recorded during the cooling process until the temperature of the dispersion matched that of its surroundings.…”

“…[10] 4 However, other NPs, including carbon nanotubes, [11] graphene NPs, [12] and neodymium-doped NPs,13 [13] also present a remarkable photothermal conversion efficiency and, additionally, provide a near-infrared (NIR) fluorescence signal which can be used to track the location of the NPs inside the body. Furthermore, fluorescent NPs can provide additional functionalities, such as intratumoral temperature sensing.…”

LaF3 core/shell nanoparticles for subcutaneous heating and thermal sensing in the second biological-window

“…For the first experiment, an infrared thermal camera was coupled to the optical set-up in order to record the temperature of the tissue's surface and to demonstrate the differences between subtissue and surface temperatures (the latter being expected to be lower due to heat diffusion processes). 3,32,33 The steady state subtissue and surface temperatures were recorded for different 808 nm power densities and in both cases, a linear relationship was experimentally found (see Figure 3(b)). As expected, there are remarkable differences between subtissue and surface temperature, as demonstrated in previous studies dealing with ex vivo and in vivo PTTs based on heating nanoparticles.…”

“…Electronic mail: daniel.jaque@uam.es doped LaF 3 NPs and (ii) the infrared luminescence thermal sensing of Neodymium and Ytterbium co-doped core-shell LaF 3 NPs. 11,32 The multifunctional agent here developed aim to join both functionalities in a single nanostructure. The NPs presented herein are based on a core/shell structure with an Yb 3þ doped core (concentration of 10 mol.…”