Hyperthermia in the Multimodal Therapy of Advanced Rectal Carcinomas

Wust, Peter; Gellermann, Johanna; Rau, Beate; Löffel, J.; Speidel, Andrea; Stahl, H.; Riess, Hanno; Vogl, T. J.; Félix, R.; Schlag, Peter M.

doi:10.1007/978-3-642-80035-1_18

Cited by 17 publications

(3 citation statements)

References 86 publications

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“…The promising results of hyperthermia obtained in preclinical studies initiated the development of various hyperthermia systems using the capacitive or inductive method for depositing electromagnetic energy in the tumor [23]. The first hyperthermia devices were developed for application to the surface of the body, and were used to treat selected superficial tumors (e. g. advanced breast carcinoma and malignant melanoma).…”

Section: Discussionmentioning

confidence: 99%

Endohyperthermia - Experimental Evaluation of a New Therapeutic Approach for Treatment of Biliary Carcinoma

Weigert

Eckel²,

Born³

et al. 2000

Endoscopy

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Section: Discussionmentioning

confidence: 99%

Endohyperthermia - Experimental Evaluation of a New Therapeutic Approach for Treatment of Biliary Carcinoma

Weigert

Eckel²,

Born³

et al. 2000

Endoscopy

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“…TRT has been reported to yield higher complete and durable responses compared to radiotherapy alone (RT) in both superficial and deep-seated tumours [8][9][10], and it is believed to be another promising treatment modality for the management of advanced cervical cancer [11][12][13]. However, the late effects of TRT for patients with FIGO Stage IIIB cervical carcinomas has been controversial [11][12][13].…”

Section: Introductionmentioning

confidence: 99%

A randomized clinical trial of radiation therapy versus thermoradiotherapy in stage IIIB cervical carcinoma

Hirabayashi

Nagata

Harima

et al. 2009

International Journal of Hyperthermia

119

103

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To clarify the role of thermoradiotherapy for FIGO Stage IIIB cervical carcinomas, both the clinical response and survival of patients treated with radio-or thermoradiotherapy were investigated. Forty patients with Stage IIIB uterine cervix carcinoma were treated with external beam irradiation to the pelvis, combined with iridium 192 high-dose-rate intracavitary brachytherapy. All patients were divided randomly into the following two groups: the radiotherapy (RT) group of 20 patients, who underwent radiotherapy alone; and the thermoradiotherapy (TRT) group of 20 patients, who underwent three sessions of hyper-thermia in addition to radiotherapy. The primary endpoint of this study was local complete response and survival. A complete response was achieved in 50% (10 of 20) in the RT group versus 80% (16 of 20) in the TRT group ( p ¼ 0.048). The 3-year overall survival and disease-free survival of the patients who were treated with TRT (58.2 and 63.6%) were better than those of the patients treated with RT (48.1 and 45%), but these differences were not significant. The 3-year local relapse-free survival of the patients who were treated with TRT (79.7%) was significantly better than that of the patients treated with RT (48.5%) ( p ¼ 0.048). TRT, as delivered in this trial, was well tolerated and did not significantly add to either the relevant clinical acute or long-term toxicity over radiation alone. TRT resulted in a better treatment response and 3-year local relapse-free survival rate than RT for patients with FIGO Stage IIIB cervical carcinoma.

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“…Efforts to overcome this problem have included the concurrent use of chemotherapy (CT) [6] or hyperthermia (HT) [7,8]. Thermoradiotherapy (TRT; RT plus HT) has been reported to yield higher complete and durable responses compared with RT alone in both superficial and deep-seated tumors [9,10].…”

mentioning

confidence: 99%

Hyperthermia classic commentary: ‘A randomized clinical trial of radiation therapy versus thermoradiotherapy in stage IIIB cervical carcinoma’ by Yoko Harima,International Journal of Hyperthermia2001;17:97–105

Hirabayashi

Sawada

2009

International Journal of Hyperthermia

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In our classic paper, we investigated both the clinical response and survival of patients treated with radiotherapy (RT) or thermoradiotherapy (TRT; RT plus hyperthermia [HT]) for Stage IIIB cervical carcinomas. Our study clearly demonstrated that TRT can result in beneficial effects for complete response and/or local relapse-free survival. To date, six randomized trials including our study have been published on the additive effect of HT in patients with locally advanced cervical cancer. In contrast, the combination of RT and platinum-based chemotherapy (CT) has gained wide acceptance. However, two recent meta-analyses suggested that the impact of adding CT to RT is less obvious in patients with advanced-stage tumors. Conversely, four of six randomized trials comparing the results of RT alone with TRT showed a beneficial effect for the patients with Stage IIIB tumors. From this, the patients with higher stage or bulkier tumors may benefit more from the addition of HT to RT than the addition of CT. To demonstrate the effectiveness of TRT for some cancers, including locally advanced cervical cancer, well designed randomized clinical trials are necessary.

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Hyperthermia in the Multimodal Therapy of Advanced Rectal Carcinomas

Cited by 17 publications

References 86 publications

Endohyperthermia - Experimental Evaluation of a New Therapeutic Approach for Treatment of Biliary Carcinoma

Endohyperthermia - Experimental Evaluation of a New Therapeutic Approach for Treatment of Biliary Carcinoma

A randomized clinical trial of radiation therapy versus thermoradiotherapy in stage IIIB cervical carcinoma

Hyperthermia classic commentary: ‘A randomized clinical trial of radiation therapy versus thermoradiotherapy in stage IIIB cervical carcinoma’ by Yoko Harima,International Journal of Hyperthermia2001;17:97–105

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