Hyperthermia response of PEGylated magnetic graphene nanocomposites for heating applications and accelerate antibacterial activity using magnetic fluid hyperthermia

Hatamie, Shadie; Shih, Po‐Jen; Zomorod, Mahsa Soufi; Heravi, Pooyan; Ahadian, Mohammad Mahdi; Hatami, Niloofar

doi:10.1007/s00339-020-3454-3

Cited by 18 publications

(14 citation statements)

References 35 publications

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“…The peak in the SPION spectra corresponded to the C1s (285 eV), O1s (528.5 eV), and Fe2p (710.3 eV). In the D-SPION spectra, a peak corresponding to the nitrogen sign at N1s (398.2 eV) was observed [ 2 ]. XPS analysis revealed the presence of the dendrimer on the iron oxide nanoparticle surfaces.…”

Section: Resultsmentioning

confidence: 99%

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Effects of Electromagnets on Bovine Corneal Endothelial Cells Treated with Dendrimer Functionalized Magnetic Nanoparticles

et al. 2021

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To improve bovine corneal endothelial cell (BCEC) migration, enhance cell energy, and facilitate symmetric cell distribution in corneal surfaces, an electromagnet device was fabricated. Twenty nanometer superparamagnetic iron oxide nanoparticles (SPIONs) functionalized with fourth-generation dendrimer macromolecules were synthesized, and their size and structure were evaluated using transmission electron microscopy (TEM), X-ray photoelectron spectroscopy (XPS), and Fourier transform infrared spectroscopy (FTIR). The results confirmed the configuration of the dendrimer on the SPION surfaces. In vitro biocompatibility was assessed using the 3-[4,5-dimethylthiazol-2yl]-2,5-diphenyl tetrazolium bromide assay. No significant toxicity was noted on BCECs within 24 h of incubation. In the cell migration assay, cells treated with dendrimer-coated SPIONs exhibited a relatively high wound healing rate under sample addition (1 μg/mL) under a magnetic field. Real-time PCR on BCECs treated with dendrimer-coated SPIONs revealed upregulation of specific genes, including AT1P1 and NCAM1, for BCECs-dendrimer-coated SPIONs under a magnetic field. The three-dimensional dispersion of BCECs containing dendrimer-coated SPIONs under a magnetic field was evaluated using COMSOL Multiphysics software. The results revealed the BCECs-SPION vortex pattern layers in the corneal surface corresponded to the electromagnet’s displacement from the ocular surface. Magnetic resonance imaging (MRI) indicated that dendrimer-coated SPIONs can be used as a T2 contrast agent.

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Section: Resultsmentioning

confidence: 99%

“…The use of magnetic nanoparticles (MNPs) coupled with magnetic base devices has been increasing in the biomedical field [1][2][3][4]. Among them, superparamagnetic iron oxide nanoparticles (SPIONs) are widely used in nanomedicine for diagnoses, therapeutics, drug, and gene delivery systems [5][6][7][8].…”

Section: Introductionmentioning

confidence: 99%

Effects of Electromagnets on Bovine Corneal Endothelial Cells Treated with Dendrimer Functionalized Magnetic Nanoparticles

et al. 2021

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“…Another study showed that a positive zeta potential of approximately 20 ± 2 mV was particularly effective in capturing gram-negative pathogens, such as E. coli, while being ineffective for gram-positive pathogens, such as S. Aureus [ 43 ]. Notably, research regarding the antibacterial properties of GO/rGO generally uses significantly higher concentrations than the 4 μg/mL, which is regarded as the maximum non-cytotoxic concentration [ 43 , 108 ].…”

Section: Properties Of Graphene Oxide and Reduced Graphene Oxidementioning

confidence: 99%

Recent biomedical advancements in graphene oxide- and reduced graphene oxide-based nanocomposite nanocarriers

et al. 2022

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Recently, nanocarriers, including micelles, polymers, carbon-based materials, liposomes, and other substances, have been developed for efficient delivery of drugs, nucleotides, and biomolecules. This review focuses on graphene oxide (GO) and reduced graphene oxide (rGO) as active components in nanocarriers, because their chemical structures and easy functionalization can be valuable assets for in vitro and in vivo delivery. Herein, we describe the preparation, structure, and functionalization of GO and rGO. Additionally, their important properties to function as nanocarriers are presented, including their molecular interactions with various compounds, near-infrared light adsorption, and biocompatibility. Subsequently, their mechanisms and the most appealing examples of their delivery applications are summarized. Overall, GO- and rGO-based nanocomposites show great promise as multipurpose nanocarriers owing to their various potential applications in drug and gene delivery, phototherapy, bioimaging, biosensing, tissue engineering, and as antibacterial agents.

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“…The magnetic properties of the core-shell nanostructures are reported to improve due to the diverse coupling interactions between the core and shell nano particles via interfacial defect acts as anisotropy in ferro-ferri and ferro-anti ferro magnetic structures [ 33 , 34 , 35 ], which make them great candidates to use in magnetic imaging [ 36 , 37 , 38 ]. In this study, we used the seed-growth technique to prepare spherical cobalt ferrite (s-CoFe 2 O 4 ) as a magnetic core template to cover with the cubic iron oxide as shell (c-Fe 3 O 4 ) to form (s-CoFe 2 O 4 @c-Fe 3 O 4 ) core-shell NPs [ 39 , 40 , 41 , 42 ]. The WS 2 nanosheets were synthesized by a series of chemical methods followed by a non-oxygen annealing process.…”

Section: Introductionmentioning

confidence: 99%

Synergic Effect of Novel WS2 Carriers Holding Spherical Cobalt Ferrite @cubic Fe3O4 (WS2/s-CoFe2O4@c-Fe3O4) Nanocomposites in Magnetic Resonance Imaging and Photothermal Therapy for Ocular Treatments and Investigation of Corneal Endothelial Cell Migration

et al. 2020

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The design of novel materials to use simultaneously in an ocular system for driven therapeutics and wound healing is still challenging. Here, we produced nanocomposites of tungsten disulfide carriers with spherical cobalt ferrite nanoparticles (NPs) as core inside a cubic iron oxide NPs shell (WS2/s-CoFe2O4@c-Fe3O4). Transmission electron microscopy (TEM) confirmed that 10 nm s-CoFe2O4@c-Fe3O4 NPs were attached on the WS2 sheet surfaces. The cytotoxicity of the WS2 sheets and nanocomposites were evaluated on bovine cornea endothelial cells (BCECs) using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay for a duration of three days. The MTT assay results showed low toxicity of the WS2 sheets on BCECs by 67% cell viability at 100 μg/mL in 24 h, while the nanocomposites show 50% cell viability in the same conditions. The magnetic resonance imaging (MRI) of nanocomposites revealed the excellent T2-weighted imaging with an r2 contrast of 108 mM−1 S−1. The in vitro photothermal therapy based on WS2 sheets and WS2/s-CoFe2O4 @c-Fe3O4 nanocomposites using 808 nm laser showed that the maximum thermal energy dispatched in medium at different applied power densities (1200 mw, 1800, 2200, 2600 mW) was for 0.1 mg/mL of the sample solution. The migration assay of BCECs showed that the wound healing was approximately 20% slower for the cell exposed by nanocomposites compared with the control (no exposed BCECs). We believe that WS2/s-CoFe2O4@c-Fe3O4 nanocomposites have a synergic effect as photothermal therapy agents for eye diseases and could be a target in an ocular system using MRI.

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Hyperthermia response of PEGylated magnetic graphene nanocomposites for heating applications and accelerate antibacterial activity using magnetic fluid hyperthermia

Cited by 18 publications

References 35 publications

Effects of Electromagnets on Bovine Corneal Endothelial Cells Treated with Dendrimer Functionalized Magnetic Nanoparticles

Effects of Electromagnets on Bovine Corneal Endothelial Cells Treated with Dendrimer Functionalized Magnetic Nanoparticles

Recent biomedical advancements in graphene oxide- and reduced graphene oxide-based nanocomposite nanocarriers

Synergic Effect of Novel WS2 Carriers Holding Spherical Cobalt Ferrite @cubic Fe3O4 (WS2/s-CoFe2O4@c-Fe3O4) Nanocomposites in Magnetic Resonance Imaging and Photothermal Therapy for Ocular Treatments and Investigation of Corneal Endothelial Cell Migration

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