Hypertrophic pulmonary osteoarthropathy in association with pulmonary metastases from extrathoracic tumours

Hypertrophic osteoarthropathy associated with carcinoma of the oesophagus

“…We have been able to find eight cases reported with nasopharyngeal malignancies (Yacoub, Simon & Ohnsorge, 1967), two with carcinoma of the stomach (Singh, Jolly & Bansal, 1962;Yacoub et al, 1967) and five with carcinoma of the oesophagus (Cayla, Guerard des Lauriers & Coste, 1962;Coury, 1962;Peyman, 1959). In addition two cases have been reported with benign oesophageal polyps (Joplin & Fraser, 1965;Hollis, 1967) and one with achalasia of the cardia alone (Preble, 1898).…”

“…In the case of the benign polyps, the HOA regressed rapidly following excision of the tumours. Yacoub et al (1967) collected forty-one cases from the literature in which HOA was associated with lung metastases from non-pulmonary tumours. Twenty of these were from osteoor fibrosarcomata, eight were from nasopharyngeal tumours and one was from carcinoma of the stomach.…”

Treatment of hypertrophic osteoarthropathy in the case of pulmonary metastasis secondary-to-nasopharyngeal carcinoma with zoledronic acid: an enlightening experience

“…Yacoub et al described three cases of HOA resulting from pulmonary metastasis in extrathoracic malignancy. Their review of the literature suggested that metastasis from osteosarcoma accounts for 30% of cases, from fibrosarcoma for 17%, from nasopharyngeal tumours for 19.1%, from uterine tumours for 12.7% and from tumours of other regions for 21.2% of cases 9. There was a suggestion made that fibrous tumours and tumours with more fibrous stroma tends to develop HOA more than others as fibrous stroma may be a factor stimulating reflex mechanism for osteoarthropathy.…”

Digital clubbing

“…Most of the reported cases have been sarcomas, mainly of bone and soft tissues; among the rest are tumors of the nasopharynx and uterus and cervix and renal cell carcinoma. [3637] Renal cell carcinoma has been usually associated clubbing in the presence of pulmonary metastases. [3638] However, in the Vandemergel et al .…”