Hyperuricemia: a Reality in the Indian Obese

Remedios, Carlyne; Shah, Miloni; Bhasker, Aparna Govil; Lakdawala, Muffazal

doi:10.1007/s11695-012-0655-7

Cited by 50 publications

(42 citation statements)

References 11 publications

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“…8 Various studies have reported higher SUA levels in males than females. 9,10 This may be due to the presence of estrogen in premenopausal females, which enhances renal urate clearance or excretion by inhibition of renal urate reabsorption via organic ion transporter, resulting in low SUA levels. The results of our study were in concordance with the earlier published data.…”

Section: Discussionmentioning

confidence: 99%

A study of the association between hyperuricemia and knee osteoarthritis in the coastal Indian population

et al. 2018

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INTRODUCTIONHyperuricemia is an abnormally high level of uric acid in the blood. In the pH conditions of body fluid, uric acid exists largely as urate, the ion form. The amount of urate in the body depends on the balance between the amount of purines eaten in food, the amount of urate synthesised within the body (e.g. through cell turnover), and the amount of urate that is excreted in urine or through the gastrointestinal tract. In humans, the upper end of the normal range is 6mg/dL (360µmol/L) for women and 6.8mg/dL (400µmol/L) for men. ABSTRACTBackground: Hyperuricemia and knee osteoarthritis are common problems that affect the aging population and they have an increasing prevalence with obesity and hypertension. Epidemiologic and immunological studies have shown a possible relation between the two conditions. Uric acid is a common factor found in association with the evaluation and treatment of osteoarthritis. There are serious therapeutic implications, particularly in using traditional gout medications, for use in osteoarthritis treatment is to be explored in detail. Our diet contains a good amount of purine containing food stuffs. The common items which increase our uric acid levels are red meat, all alcoholic beverages, seafood and shellfish. Previous studies have shown an association between serum uric acid and generalized osteoarthritis, but with the limited studies on the evidence of association between serum uric acid and knee joint osteoarthritis. This study aims to know the association between serum uric acid levels and osteoarthritis of knee joint. Methods: This is a Cross-sectional analytical study including eight hundred and thirty patients (461 males, 369 females) in a population screening during a patient education program on joint pains. Their serum uric acid level, total count, differential count, erythrocyte sedimentation rate (ESR), height, weight, blood pressure, BMI and standing radiographs of affected knees were obtained. The presence of radiographic osteoarthritis of the knee was analyzed using Kellgren-Lawrence system. The patients were divided into cohorts with hyperuricemia and osteoarthritis and compared with the subjects without either of the problems. Results: Isolated knee joint osteoarthritis is present in 183 subjects (22%), hyperuricemia was present in 154 subjects (18.55%). There is a significant positive association present between isolated knee joint osteoarthritis and the highest level of serum uric acid (adjusted odd's ratio-2.24, 95% confidence interval-1.57-2.94). There is a significant positive association between high serum uric acid levels and progression of the knee joint osteoarthritis (highest level versus lowest level of serum uric acid odd's ratio-1.38, 95% confidence interval-0.96-2.74). Conclusions: It is concluded that knee joint osteoarthritis and its progression are associated with hyperuricemia.

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Section: Discussionmentioning

confidence: 99%

A study of the association between hyperuricemia and knee osteoarthritis in the coastal Indian population

et al. 2018

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“…In the previous studies, investigators reported that UA levels were significantly associated with BMI. Numerous epidemiological studies have shown a positive correlation between obesity and increased UA levels [30,31]. Recently, in a Mendelian randomization analysis, it was reported that UA levels were associated with BMI, and that reduction of BMI could help improve UA levels [32].…”

Section: Discussionmentioning

confidence: 99%

The relationship between body mass index and uric acid: a study on Japanese adult twins

Tanaka

Ogata

Tanaka

et al. 2015

Environ Health Prev Med

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Objectives The present study aimed to investigate the association between body mass index (BMI) and uric acid (UA) using the twin study methodology to adjust for genetic factors. Methods The association between BMI and UA was investigated in a cross-sectional study using data from both monozygotic and dizygotic twins registered at the Osaka University Center for Twin Research and the Osaka University Graduate School of Medicine. From January 2011 to March 2014, 422 individuals participated in the health examination. We measured height, weight, age, BMI, lifestyle habits (Breslow's Health Practice Index), serum UA, and serum creatinine. To investigate the association between UA and BMI with adjustment for the clustering of a twin within a pair, individual-level analyses were performed using generalized linear mixed models (GLMMs). To investigate an association with adjustment for genetic and family environmental factors, twin-pair difference values analyses were performed. Results In all analysis, BMI was associated with UA in men and women. Using the GLMMs, standardized regression coefficients were 0. Conclusions The present study shows that BMI was significantly associated with UA, after adjusting for both genetic and familial environment factors in both men and women.

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“…Obesity in women and hypertriglyceridemia in men may aggravate hyperuricemia to develop gout [10]. In developing countries, for example, an Indian study reported that the prevalence of hyperuricemia increased significantly in obese population [11]. This is also the case in Bangladesh population [12].…”

Section: Introductionmentioning

confidence: 98%

Hyperuricemia and its association with adiposity and dyslipidemia in Northwest China: results from cardiovascular risk survey in Xinjiang (CRS 2008–2012)

Liu

Song

et al. 2020

Lipids Health Dis

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Background: Hyperuricemia predisposes to gout, which may result in tophi, kidney stones, or urate nephropathy even kidney failure. Many metabolic risk factors and disorders has been recognized as a key risk factor contributing to development of hyperuricemia. Aim: To determine the prevalence of hyperuricemia and its association with adiposity and dyslipidemia. Methods: We recruited non-hospitalized participants (aged ≥35 years) in Xinjiang, a northwest part of China based on the Cardiovascular Risk Survey (CRS 2008(CRS -2012. Information of general health status, seafood or internal organs intake and history of disease were obtained by using an interview-based questionnaire. The levels of serum uric acid (sUA) and creatinine and lipid profiles were measured. A multivariate logistic regression model was performed to assess the association between prevalence of hyperuricemia and adiposity and dyslipidemia. (Continued on next page)Results: This study recruited 16,611 participants, and 14,618 was included (mean age of 50.5 ± 12.6 years, 46.6% was males). The study population comprised three ethnic groups with 39.4% of Han, 32.6% of Uygur and 28% of Kazakh Chinese. The overall prevalence of hyperuricemia was 9.1% (95% CI: 8.6 to 9.6) and it was11.8% in men was 6.7% in women. The three ethnic groups also had different hyperuricemia prevalence with 15.4% in Han, 4.6% in Uygur and 5.5% in Kazakh Chinese, which corresponding to a respective mean sUA levels of 306.2 ± 86.9, 249.4 ± 76.1 and 259.8 ± 78.7 μmol/L. Participants with diabetes, hypertension or hypertriglyceridemia and higher blood urea nitrogen (BUN), estimated glomerular filtration rate (eGFR), fasting blood glucose (FBG), triglycerides (TG), total cholesterol (TC) had higher levels of sUA (P < 0.001 respectively). Multivariate logistic regression analysis revealed that age, gender, ethnicity, drinking, obesity, waist circumference, TG (≥2.26 mmol/L), TC (≥6.22 mmol/L) are major risk factors for hyperuricemia. Compared to the 35-44-year age group [adjusted odds ratio (AOR) = 1], the risk of hyperuricemia increased 1.61-fold in the 65-74-year age group (AOR = 1.61, 95% CI: 1.34-1.91; P < 0.001), and 1.71-fold in the 75-and older age group (AOR = 1.71, 95% CI: 1.27-2.29; P < 0.001). There was a 1.45-fold higher risk of hyperuricemia in men (AOR = 1.45, 95% CI: 1.24-1.68; P < 0.001) compared to women. Further, the risk of hyperuricemia increased significantly with drinking (AOR = 1.36; 95% CI: 1.16-1.61; P < 0.001), overweight (AOR = 1.25; 95% CI: 1.06-1.48; P = 0.01), obesity (AOR = 1.28; 95% CI: 1.10-1.49; P < 0.001), waist circumference (AOR = 1.48; 95% CI: 1.24-1.78; P < 0.001), TC (≥6.22 mmol/L, AOR = 1.45; 95% CI: 1.19-1.75; P < 0.001), TG (≥2.26 mmol/L, AOR = 2.74; 95% CI: 2.39-3.14; P < 0.001). Conclusions: These findings documented that the hyperuricemia is prevalent in the economically developing regions of northwest China. Hyperuricemia is associated with advanced age, male ender and general metabolic and cardiovascular risk factors. Obesity and dyslip...

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Hyperuricemia: a Reality in the Indian Obese

Cited by 50 publications

References 11 publications

A study of the association between hyperuricemia and knee osteoarthritis in the coastal Indian population

A study of the association between hyperuricemia and knee osteoarthritis in the coastal Indian population

The relationship between body mass index and uric acid: a study on Japanese adult twins

Hyperuricemia and its association with adiposity and dyslipidemia in Northwest China: results from cardiovascular risk survey in Xinjiang (CRS 2008–2012)

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