Hyperuricemia and Impaired Renal Function: A Prospective Cohort Study

Aiumtrakul, Noppawit; Wiputhanuphongs, Puvanant; Supasyndh, Ouppatham; Satirapoj, Bancha

doi:10.1159/000511196

Cited by 10 publications

(5 citation statements)

References 41 publications

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“…In our two previous clinical trials, the oral administration of the combined dose of glycine and tryptophan led to a decreased concentration of serum uric acid because of the increased urate excretion into the urine [20,21]. A recent prospective cohort study suggested that serum uric acid levels are independently associated with the incidence of impaired renal function and renal progression [22], and a meta-analysis reported that uric acid-lowering therapy effectively regards CKD progression [23]. Furthermore, serum uric acid is associated with CKD incidence [24,25].…”

Section: Introductionmentioning

confidence: 93%

Enhancing effect of glycine and tryptophan mixture on estimated glomerular filtration rate in healthy participants: A randomized, double-blind, placebo-controlled parallel study

Oshima¹,

Shiiya²,

Nakamura³

2021

FFHD

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Background: The mixture of glycine and tryptophan exhibited serum uric acid-lowering effects in our previous clinical trial.Objective: Using a randomized, double-blind, placebo-controlled, and parallel study design, this current study aimed to examine whether this mixture enhanced the estimated glomerular filtration rate (eGFR) as an indicator of renal function in healthy individuals.Methods: Healthy Japanese adult males and females ingested a powder mixture containing 3.0 g of glycine and 0.2 g of tryptophan or a placebo powder once daily at bedtime for 8 weeks.Results: After 8 weeks of continual ingestion, the combined glycine and tryptophan supplementation significantly enhanced eGFR. It also decreased serum uric acid levels, consistent with our previous reports. Meanwhile, the continual ingestion of the mixture had no influence on serum total or essential amino acids.Conclusions: The current study demonstrated that the combined oral administration of glycine and tryptophan significantly elevated the eGFR of healthy participants. However, further investigation is required to elucidate the detailed mechanisms underlying the potential therapeutic or preventive effect of combined glycine and tryptophan supplementation. Nevertheless, the uric acid-lowering effect of glycine and tryptophan mixture has the potential to directly influence renal function.Keywords: glycine, tryptophan, estimated glomerular filtration rate, uric acid

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Section: Introductionmentioning

confidence: 93%

Enhancing effect of glycine and tryptophan mixture on estimated glomerular filtration rate in healthy participants: A randomized, double-blind, placebo-controlled parallel study

Oshima¹,

Shiiya²,

Nakamura³

2021

FFHD

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“…Hyperuricemia (HUA) is a status of high SUA concentration, which may lead to urate crystals being deposited in joints, tendons, and other tissues, and could also elevate the risk of gout or other comorbidities development [ 4 , 5 ]. Besides gout, the relationships between HUA and dyslipidemia [ 6 ], cardiovascular disease (CVD) [ 7 ], metabolic syndrome (MetS) [ 4 ], insulin resistance [ 8 ], hypertension [ 9 ] or renal disease [ 10 ] have been observed in previous studies.…”

Section: Introductionmentioning

confidence: 99%

The Prevalence of Hyperuricemia and Its Correlates among Adults in China: Results from CNHS 2015–2017

et al. 2022

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This study aimed to investigate the prevalence of hyperuricemia (HUA) and associated risk factors in Chinese adults aged 18 to 59 years. All the data were collected from the China Nutrition and Health Surveillance during the period 2015–2017, which adopted a stratified, multistage, random sampling method on a national scale. A total of 52,627 participants aged 18 years or older were included in this study. The definition of hyperuricemia was 420 μmol/L for male and 360 μmol/L for female. The Rao–Scott chi-square test was used to compare the differences in prevalence between or among the subgroups. A weighted two-level multivariate survey-logistic regression was used to detect the correlations between HUA and demographic, physical, lifestyle and metabolic factors. The total prevalence of HUA was 15.1%, and that was higher in male, current smokers, higher BMI and less physical activities subgroups, and also in noninfectious chronic diseases (NCDs) subgroups. The subgroups of non-vegetarian diet, insufficient vegetable intakes and excessive red meat and alcohol intakes had significantly higher HUA prevalence. After introducing all the variables in the survey-logistic regression, gender, age, BMI, physically active, hypertension, diabetes mellitus, bean and nut intake, vegetable intake, red meat intake, alcohol consumption and vegetarian were associated with HUA. Among the significant variables, age and physical active served as a protective factor, and BMI showed to be a risk factor for HUA. Hypertension and dyslipidemia could increase the risk for HUA, while diabetes mellitus was shown a negative association with it. For dietary factors, vegetarian diet, sufficient beans and nuts and vegetables intake could lower the risk of HUA, but more alcohol could increase the risk of HUA. Dietary factor played a key role in HUA. It suggested that the intervention of dietary factor should receive more attention to ameliorate the high prevalence of HUA in China.

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“…A separate significant finding worth noting was that the association between hyperuricemia and the new onset of CKD in males was relatively stronger than that in females, with the adjusted HR of hyperuricemia for CKD being 1.925 (1.724–2.150) and 1.676 (1.530–1.848) for males and females, respectively. Previous studies have investigated sex differences in the correlations between hyperuricemia and incident CKD but obtained mixed results [ 13 , 42 , 43 ]. Estrogen is the most commonly considered reason for this sex difference, as it can cause the excretion of urate through urine [ 44 ] and inhibit the generation of uric acid by xanthine oxidase [ 45 ].…”

Section: Discussionmentioning

confidence: 99%

Serum uric acid is associated with chronic kidney disease in elderly Chinese patients with diabetes

Zhou,

Ke,

Yan

et al. 2023

Renal Failure

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Background The relationship between hyperuricemia and chronic kidney disease (CKD) has been investigated extensively. However, studies on elderly individuals are still limited. Moreover, there is no consensus on whether hyperuricemia or elevated serum uric acid (SUA) within the normal range is correlated with the new onset of CKD and whether there are differences between males and females. Methods We included 39039 elderly diabetic patients without CKD at baseline from a community-based cohort in Wuhan, China. The outcome event was the new onset of CKD (defined as an estimated glomerular filtration rate < 60 mL/min/1.73 m 2 ). Multivariate Cox models were used to assess the adjusted hazard ratio (HR). Results During the 2-year follow-up period, 3162 (8.10%) patients with diabetes developed new-onset CKD. The optimal cutoff value of SUA for incident CKD was 347.4 μmol/L. The adjusted HRs of hyperuricemia for new-onset CKD were 1.925 (1.724–2.150) and 1.676 (1.520–1.848) for males and females, respectively. The risk of developing CKD increased across the Q4 group up to 2.242 times for their counterparts in the lowest SUA quartile, independent of age, sex, diabetes duration, obesity, hypertension, systolic blood pressure, diastolic blood pressure, smoking, drinking, dyslipidemia, triglyceride, total cholesterol, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, and fasting plasma glucose. Conclusions Hyperuricemia is an independent predictor of incident CKD. Elevated SUA was linearly correlated with CKD in elderly patients with diabetes, showing a relatively higher intensity among males compared with that among females. The optimal cutoff value of SUA for the risk of new-onset CKD in elderly patients with diabetes was 347.4 μmol/L.

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Hyperuricemia and Impaired Renal Function: A Prospective Cohort Study

Cited by 10 publications

References 41 publications

Enhancing effect of glycine and tryptophan mixture on estimated glomerular filtration rate in healthy participants: A randomized, double-blind, placebo-controlled parallel study

Enhancing effect of glycine and tryptophan mixture on estimated glomerular filtration rate in healthy participants: A randomized, double-blind, placebo-controlled parallel study

The Prevalence of Hyperuricemia and Its Correlates among Adults in China: Results from CNHS 2015–2017

Serum uric acid is associated with chronic kidney disease in elderly Chinese patients with diabetes

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