Hyperuricemia as a potential risk factor for type 2 diabetes and diabetic
            nephropathy

Shah, Pratik; Bjornstad, Petter; Johnson, Richard J.

doi:10.5935/0101-2800.20160061

Cited by 9 publications

(5 citation statements)

References 14 publications

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“…[15,16,22] Previous studies focused on clinical onset patients with hyperuricemia or a combination of other complications. [3–5,23–25] Nevertheless, our research attempts to elucidate possible pathological alterations in asymptomatic young patients with primary hyperuricemia, with an emphasis on oxidative stress and inflammation. Hyperuricemia is a metabolic disease related to habits, customs, age, gender, and inherited factors, and hyperuricemia is also correlated with obesity, hypertension, diabetes, renal failure, dyslipidemia, and liver diseases.…”

Section: Discussionmentioning

confidence: 99%

“…The incidence of hyperuricemia is increasing gradually worldwide with the improvement in human living standard and dietary structure changes, as well as genetic and environmental factors. [1,2] Epidemiological studies [3–5] at present showed that hyperuricemia, an independent risk factor for the morbidity and mortality of chronic diseases, may be related to obesity, hypertension, diabetes, and metabolic syndrome. Ogura et al [6] studied the relationship between obesity and serum UA and demonstrated a 30% increase in fat as serum UA levels increased 59.5 mol/L.…”

Section: Introductionmentioning

confidence: 99%

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Relationship between oxidative stress and inflammation in hyperuricemia

Zhou

Zhao²,

Pu³

et al. 2018

Medicine

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The average age of hyperuricemia patients has gradually decreased, but young patients with primary hyperuricemia often do not exhibit clinical symptoms and have not received sufficient attention. However, a lack of symptoms with primary hyperuricemia does not mean that high serum uric acid (UA) levels cannot lead to pathological effects, such as oxidative stress and inflammation, and the specific damage is still unclear. We aimed to determine the relationship between oxidative stress and inflammation to explore the possible role of pathological damage in asymptomatic young patients with primary hyperuricemia.A total of 333 participants were enrolled in our study: 158 asymptomatic young patients with primary hyperuricemia and 175 healthy persons from a health check-up population. Malondialdehyde (MDA), superoxide dismutase (SOD), interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α), and general biochemical markers were measured.We found no differences in biochemical markers (fasting glucose, TG, TC, LDL-C, HDL-C, SCr, BUN, AST, and ALT) between the patients and healthy persons. Subsequent analyses of oxidative stress and inflammation revealed that the serum levels of MDA, IL-6, and TNF-α in the patients were significantly higher than those in the healthy control group (P < .001), and the SOD activity was significantly lower (P < .001). As the UA levels increased, MDA increased significantly and SOD decreased significantly; likewise, IL-6 and TNF-α increased significantly as the UA level increased. MDA showed a significant positive correlation with IL-6 (r = 0.367, P < .001) and TNF-α (r = 0.319, P < .001), and SOD was negatively correlated with IL-6 (r = −0.241, P < .01) and TNF-α (r = −0.308, P < .001). Multivariable logistic regression analysis showed that UA (OR: 2.379, 95% CI: 1.698–3.286, P < .001; OR: 3.261, 95% CI: 1.729–3.857, P < .001; for IL-6 and TNF-α, respectively) and MDA (OR: 1.836, 95% CI: 1.283–2.517, P < .01; OR: 2.532, 95% CI: 1.693–3.102, P < .001; for IL-6 and TNF-α, respectively) were risk factors for high IL-6 and TNF-α and that SOD (OR: 0.517, 95% CI: 0.428–0.763, P < .01; OR: 0.603, 95% CI: 0.415–0.699, P < .001; for IL-6 and TNF-α, respectively) was a protective factor.In our study, some abnormal pathological effects were found in asymptomatic young patients with hyperuricemia, suggesting that in young hyperuricemia patients, oxidative stress, inflammation and the inflammatory response may be related to the oxidative stress induced by UA. Therefore, we should pay more attention to the pathological damage caused by these alterations.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Relationship between oxidative stress and inflammation in hyperuricemia

Zhou

Zhao²,

Pu³

et al. 2018

Medicine

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show abstract

“…32 In a study exploring the effect of hyperuricemia on T2DM and DN, it was pointed out that hyperuricemia is a potential risk factor for T2DM and DN. 33 It can be known that T2DM obese patients with hyperuricemia are more likely to have DN. In our study, it was proved that hyperuricemia is a risk factor for DN in obese T2DM patients.…”

Section: Hyperuricemiamentioning

confidence: 99%

<p>Study on Risk Factors of Diabetic Nephropathy in Obese Patients with Type 2 Diabetes Mellitus</p>

Hu¹,

Zhang²

2020

IJGM

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The purpose of this study was to identify diabetic nephropathy risk factors in type 2 diabetes mellitus obese people based on community type 2 diabetes mellitus patients. Patients and Methods: In the community in Shanghai, we conduct a questionnaire, physical examination, and biochemical examination. The 406 patients included in the analysis were divided into two groups based on whether or not they had diabetic nephropathy. The influencing factors of type 2 diabetes mellitus obese patients were screened by the least absolute shrinkage and selection operator method, and then the influencing factors detected by the least absolute shrinkage and selection operator method were included in the binary logistic regression analysis, and the risk factors for diabetic nephropathy in obese people with type 2 diabetes mellitus were obtained. Finally, the nomogram and forest plot are used to visualize the binary logistic regression results, and the calibration plot and receiveroperating characteristic curve are used to verify the result. Results: The results showed that family history of diabetes (OR= 2.091, P= 0.002), disease course (OR=1.050, P= 0.007). hypertension (OR=1.768, P=0.042), hyperuricemia (OR=2.263, P=0.003), systolic blood pressure (OR=1.027, P<0.001), and glycosylated haemoglobin A1c (OR=1.358, P<0.001) were risk factors for diabetic nephropathy. Conclusion: For obese patients with type 2 diabetes mellitus, they should pay attention to family history of diabetes, disease course and hyperuricemia. Hypertension should be concerned and strictly controlled. Systolic blood pressure and glycosylated haemoglobin A1c will help prolong the survival of diabetic nephropathy patients.

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“…12 Increased activity of the hexose monophosphate (HMP) shunt linked to insulin resistance causes hyperuricemia in diabetic patients. 13 Hyperuricemia increases morbidity and mortality among patients with diabetes. It results in a poor prognosis on the diabetic complications, correlated with increased prevalence of diabetic peripheral neuropathy, retinopathy and nephropathy.…”

Section: Introductionmentioning

confidence: 99%

<p>Prevalence and Determinants of Hyperuricemia in Type 2 Diabetes Mellitus Patients Attending Jimma Medical Center, Southwestern Ethiopia, 2019</p>

Kene

Wondimnew

Welde

et al. 2020

DMSO

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Objective: To assess the prevalence and determinants of hyperuricemia among type 2 diabetic patients on follow-up at Jimma Medical Center from March 1 to June 30, 2019. Methods: This institution-based cross-sectional study was used to assess the level of serum uric acid in type 2 diabetic patients attending their follow-up at Jimma Medical Center chronic illness clinic. A systematic sampling technique was used to include 287 type 2 diabetic patients in the study and an interviewer-based questionnaire was used to collect important data from each participant. Five milliliters of blood were collected from each participant under sterile conditions and serum was separated by centrifugation at 3000 rpm for 10 minutes. Serum was stored at −20°C and analyzed for serum uric acid using an ABX Pentra 400 clinical chemistry analyzer. Bivariate and multivariable binary logistic regression were used to assess significant associations between hyperuricemia and independent factors. A p-value of <0.05 was considered significant in the final model. Results: The mean±SD age of the study participants was 51.79±14.36 years. The prevalence of hyperuricemia was found to be 22% (n=66/287) in the study population. Hyperuricemia was common in those aged ≥60 years and males. Obesity (AOR=7.84, 95% CI=2.005-30.666), duration of diabetes mellitus (DM) ≥10 years (AOR=3.963, 95% CI=1.902-8.259), family history of CVD (AOR=2.929, 95% CI=1.124-7.630), alcohol drinking (AOR=5.83, 95% CI=2.341-14.545) and increased DBP (AOR=4.198, 95% CI=1.772-9.949) were determinant variables for hyperuricemia in type 2 DM. Conclusion: Hyperuricemia was relatively common among type 2 diabetic patients. The prevalence of hyperuricemia was common among patients with obesity, a long duration of DM and increased diastolic blood pressure, and alcohol drinkers. There is a need to raise awareness of lifestyle modification, healthy behavior and early diagnosis of hyperuricemia in type 2 diabetic patients.

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Hyperuricemia as a potential risk factor for type 2 diabetes and diabetic nephropathy

Cited by 9 publications

References 14 publications

Relationship between oxidative stress and inflammation in hyperuricemia

Relationship between oxidative stress and inflammation in hyperuricemia

<p>Study on Risk Factors of Diabetic Nephropathy in Obese Patients with Type 2 Diabetes Mellitus</p>

<p>Prevalence and Determinants of Hyperuricemia in Type 2 Diabetes Mellitus Patients Attending Jimma Medical Center, Southwestern Ethiopia, 2019</p>

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