Hypoadiponectinemia in Patients With Paroxysmal Atrial Fibrillation

Abstract

Background and ObjectivesAdiponectin is an adipose tissue-derived hormone that has beneficial effects on cardiac function and has been reported to be associated with lipid metabolism, glucose metabolism, and insulin resistance. Serum levels of adiponectin are reduced in obese individuals compared with non-obese individuals. Obesity is associated with an increased incidence of atrial fibrillation (AF); however, the role of adiponectin in AF is unclear. The aim of this study is to evaluate the relationship between the plasma adiponectin level and AF.Subjects and MethodsSixty-one consecutive patients were prospectively enrolled for this study. Subjects were divided into two groups: patients with AF (n=30) and controls (n=31). Laboratory evaluation, including levels of plasma adiponectin, was performed and echocardiographic parameters were measured.ResultsThe baseline characteristics were not different between the two groups. The plasma adiponectin level of patients in the AF group was significantly lower than in the control group (14.9±7.2 vs. 19.±8.9 µg/mL, p<0.05). In addition, when we divided the AF patients into paroxysmal and chronic AF, the plasma adiponectin level was significantly lower in patients with paroxysmal AF, compared with the control group. In multiple binary logistic regression analysis to evaluate the independent predictors for AF, adiponectin and left atrial diameter were strong independent predictors of AF.ConclusionIn this study a lower plasma adiponectin concentration was significantly associated with that of paroxysmal AF. Hypoadiponectinemia can potentially be an important risk factor for AF.

The associations of leptin, adiponectin and resistin with incident atrial fibrillation in women

“…In this study, Shimano et al found that patients with permanent AF had relatively higher levels of adiponectin and those with paroxysmal AF had lower levels compared with controls. An additional hospital-based case–control trial of 60 patients by Choi et al demonstrated similar findings of lower adiponectin concentrations in patients with paroxysmal AF and concentrations similar to controls in those with permanent AF 31. In contrast, the analysis by Rienstra et al described earlier, found no clear association between adiponectin and AF risk after multivariable adjustment 20.…”

Leptin, adiponectin, tumor necrosis factor α, and irisin concentrations as factors linking obesity with the risk of atrial fibrillation among inpatients with cardiovascular diseases

“…This is in line with the results reported by other investigators, although they did not analyze indexed values of adipocytokines. 1-6,10,11,16-18,21, [23][24][25][26][27][28][29][30][31][32][33] On the other hand, in the studies by Kim et al, 13 Kawada, 12 Macheret et al, 15 and Barnett and Piccini, 27 high circulating ADA levels were independently associated with an increased risk of AF. In addition, Ermakov et al 30 did not find any significant associations between plasma leptin and ADA concentrations and the risk of AF.…”

Clinical implications of serum adiponectin on progression of atrial fibrillation

“…In addition, adiponectin concentration was shown to be higher in Whites than in Blacks, and a high concentration was shown to be independently associated with a greater risk of an incident AF [10] . Choi et al reported a significant association between a relatively low plasma adiponectin concentration and paroxysmal AF [11] . However, Ermakov et al showed that among women, elevated levels of serum resistin were significantly associated with high rates of an incident AF, and that it partially mediated the association between the BMI and AF, but that leptin and adiponectin elevations were not significantly associated with AF [12] .…”